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dc.contributor.authorMarkussen, Heidi Øksnes
dc.contributor.authorLehmann, Sverre
dc.contributor.authorNilsen, Roy Miodini
dc.contributor.authorNatvig, Gerd Karin
dc.date.accessioned2019-08-16T14:59:27Z
dc.date.available2019-08-16T14:59:27Z
dc.date.issued2019-01-11
dc.identifier.citationMarkussen H, Lehmann S, Nilsen RM, Natvig GK. Health-related quality of life as predictor for mortality in patients treated with long-term mechanical ventilation. BMC Pulmonary Medicine. 2019;19(1):1-12eng
dc.identifier.urihttp://hdl.handle.net/1956/20684
dc.description.abstractBackground The Severe Respiratory Insufficiency (SRI) questionnaire is a specific measure of health-related quality of life (HRQoL) in patients treated with long-term mechanical ventilation (LTMV). The aim of the present study was to examine whether SRI sum scores and related subscales are associated with mortality in LTMV patients. Methods The study included 112 LTMV patients (non-invasive and invasive) from the Norwegian LTMV registry in Western Norway from 2008 with follow-up in August 2014. SRI data were obtained through a postal questionnaire, whereas mortality data were obtained from the Norwegian Cause of Death Registry. The SRI questionnaire contains 49 items and seven subscales added into a summary score (range 0–100) with higher scores indicating a better HRQoL. The association between the SRI score and mortality was estimated as hazard ratios (HRs) with 95% confidence intervals (95% CI) using Cox regression models and HRs were estimated per one unit change in the SRI score. Results Of the 112 participating patients in 2008, 52 (46%) had died by August 2014. The mortality rate was the highest in patients with chronic obstructive pulmonary disease (75%), followed by patients with neuromuscular disease (46%), obesity hypoventilation syndrome (31%) and chest wall disease (25%) (p < 0.001). Higher SRI sum scores in 2008 were associated with a lower mortality risk after adjustment for age, education, hours a day on LTMV, time since initiation of LTMV, disease category and comorbidity (HR 0.98, 95% CI: 0.96–0.99). In addition, SRI-Physical Functioning (HR 0.98, 95% CI: 0.96–0.99), SRI-Psychological Well-Being (HR 0.98, 95% CI: 0.97–0.99), and SRI-Social Functioning (HR 0.98, 95% CI: 0.97–0.99) remained significant risk factors for mortality after covariate adjustment. In the subgroup analyses of patient with neuromuscular diseases we found significant inverse associations between some of the SRI subscales and mortality. Conclusions SRI score is associated with mortality in LTMV-treated patients. We propose the use of SRI in the daily clinic with repeated measurements as part of individual follow-up. Randomized clinical trials with interventions aimed to improve HRQoL in LTMV patients should consider the SRI questionnaire as the standard HRQoL measurement.eng
dc.language.isoengeng
dc.publisherBMCeng
dc.rightsAttribution CC BYeng
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/eng
dc.subjectLong-term mechanical ventilationeng
dc.subjectHealth-related quality of lifeeng
dc.subjectPredictorseng
dc.subjectMortalityeng
dc.subjectSurvivaleng
dc.subjectThe severe respiratory insufficiency (SRI) questionnaireeng
dc.titleHealth-related quality of life as predictor for mortality in patients treated with long-term mechanical ventilationeng
dc.typeJournal articleeng
dc.date.updated2019-05-24T10:49:26Z
dc.rights.holderCopyright The Author(s) 2019eng
dc.type.versionpublishedVersioneng
bora.peerreviewedPeer reviewedeng
dc.type.documentJournal article
dc.identifier.cristinID1692649
dc.identifier.doi10.1186/s12890-018-0768-4eng
dc.source.issn1471-2466eng
dc.relation.journalBMC Pulmonary Medicine


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