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dc.contributor.authorJebsen, Nina Louise
dc.contributor.authorApelseth, Torunn Oveland
dc.contributor.authorHaugland, Hans Kristian
dc.contributor.authorRekdal, Øystein
dc.contributor.authorPatel, Hamina
dc.contributor.authorGjertsen, Bjørn Tore
dc.contributor.authorJøssang, Dag Eirik
dc.date.accessioned2019-08-23T09:11:03Z
dc.date.available2019-08-23T09:11:03Z
dc.date.issued2019-06-10
dc.identifier.citationJebsen N, Apelseth TO, Haugland HK, Rekdal Ø, Patel, Gjertsen BT, Jøssang DE. Enhanced T-lymphocyte infiltration in a desmoid tumor of the thoracic wall in a young woman treated with intratumoral injections of the oncolytic peptide LTX-315: A case report. Journal of Medical Case Reports. 2019;13:177eng
dc.identifier.urihttp://hdl.handle.net/1956/20715
dc.description.abstract<p>Background: Desmoid tumors are intermediary malignant, fibrous lesions occurring in various soft tissues. Surgical treatment is relentlessly challenging because of the propensity for local aggressive behavior and high risk of recurrence. Consequently, a wide range of oncological drugs and radiation therapy are being used; however, outcomes are unpredictable. We investigated whether local treatment with an oncolytic peptide could be beneficial in a patient with an unresectable desmoid tumor.</p> <p>Case presentation: In a young 29-year-old Caucasian woman who was diagnosed with a retromammary desmoid tumor infiltrating deeply into the anterior thoracic wall, surgery was considered excessively mutilating, and observation was recommended. The lesion progressed, however, and caused debilitating pain, despite nonsteroidal anti-inflammatory medication. Subcutaneous injections of human interferon-&alpha; (Multiferon&reg;) resulted in reduced growth kinetics but had to be terminated because of development of symptomatic pneumonitis. Frequently used oncological treatment was withheld because of the toxicity profile, and the patient was instead included in a phase I study investigating transdermal intratumoral injection of LTX-315, an oncolytic peptide that induces anticancer immune responses (ClinicalTrials.gov,&nbsp;NCT01986426). A marked increase of CD8+&nbsp;tumor-infiltrating T cells in the lesion was complemented by upregulation of immune gene signature (including effector T-cell, T-helper type 1 cell, chemokine, and cytokine genes). These changes were followed by gradual symptom relief and long-term disease stabilization, indicating clinical benefit. LTX-315 was well tolerated until termination in week 16 after a serious allergic reaction.</p> <p>Conclusions: Our patient was treated with repeated intratumoral injections of LTX-315, resulting in tumor regression accompanied by upregulation of immune genes and T-cell infiltration. Local application of immunotherapy, minimizing systemic side effects, represents a novel treatment modality in desmoid tumors that should be tested in further clinical trials.</p>eng
dc.language.isoengeng
dc.publisherBMCeng
dc.rightsAttribution CC BYeng
dc.rights.urihttp://creativecommons.org/licenses/by/4.0eng
dc.subjectDesmoid tumorseng
dc.subjectIntratumoral oncolytic peptideeng
dc.subjectT-cell infiltrationeng
dc.subjectImmune gene expression profileseng
dc.titleEnhanced T-lymphocyte infiltration in a desmoid tumor of the thoracic wall in a young woman treated with intratumoral injections of the oncolytic peptide LTX-315: A case reporteng
dc.typeJournal articleeng
dc.date.updated2019-08-07T11:41:16Z
dc.rights.holderCopyright 2019 The Author(s)eng
dc.type.versionpublishedVersioneng
bora.peerreviewedPeer reviewedeng
dc.type.documentJournal article
dc.identifier.cristinID1712946
dc.identifier.doi10.1186/s13256-019-2088-6eng
dc.source.issn1752-1947eng
dc.relation.journalJournal of Medical Case Reports


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