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dc.contributor.authorBruserud, Øystein
dc.contributor.authorBrenner, Annette
dc.date.accessioned2019-09-10T12:01:02Z
dc.date.available2019-09-10T12:01:02Z
dc.date.issued2019-07-11
dc.identifier.citationBruserud Ø, Brenner AK. Functional toll-like receptors (TLRs) are expressed by a majority of primary human acute myeloid leukemia cells and inducibility of the TLR signaling pathway is Associated with a more favorable phenotype. Cancers. 2019;11(7):973.eng
dc.identifier.urihttp://hdl.handle.net/1956/20814
dc.description.abstractAcute myeloid leukemia (AML) is a highlyheterogeneous disease withregardto biological characteristics and receptor expression. Toll-like receptors (TLRs) are upstream to the transcription factor NFκB and part of the innate immune system. They are differentially expressed on AML blasts, and during normal hematopoiesis they initiate myeloid differentiation. In this study, we investigated the response upon TLR stimulation in an AML cohort (n = 83) by measuring the increase of NFκB-mediated cytokine secretion. We observed that TLR4 is readily induced in most patients, while TLR1/2 response was more restricted. General response to TLR stimulation correlated with presence of nucleophosmin gene mutations, increased mRNA expression of proteins, which are part of the TLR signaling pathway and reduced expression of transcription-related proteins. Furthermore, signaling via TLR1/2 appeared to be linked with prolonged patient survival. In conclusion, response upon TLR stimulation, and especially TLR1/2 induction, seems to be part of a more favorable phenotype, which also is characterized by higher basal cytokine secretion and a more mature blast population.eng
dc.language.isoengeng
dc.publisherMDPIeng
dc.rightsAttribution CC BYeng
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/eng
dc.subjectAcute myeloid leukemiaeng
dc.subjectToll-like receptorseng
dc.subjectCytokineeng
dc.subjectEpigenetic modificationeng
dc.subjectSurvivaleng
dc.titleFunctional toll-like receptors (TLRs) are expressed by a majority of primary human acute myeloid leukemia cells and inducibility of the TLR signaling pathway is associatedwith a more favorable phenotypeeng
dc.typeJournal articleeng
dc.date.updated2019-07-11T09:56:19Z
dc.rights.holderCopyright 2019 The Authors.eng
dc.type.versionpublishedVersioneng
bora.peerreviewedPeer reviewedeng
dc.type.documentJournal article
dc.identifier.cristinID1711245
dc.identifier.doi10.3390/cancers11070973eng
dc.source.issn2072-6694eng
dc.relation.journalCancers


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