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dc.contributor.authorLilletveit, Marius
dc.date.accessioned2019-09-11T09:20:19Z
dc.date.available2019-09-11T09:20:19Z
dc.date.issued2019-09-04
dc.date.submitted2019-09-03T22:00:02Z
dc.identifier.urihttp://hdl.handle.net/1956/20821
dc.description.abstract<p>Hydrogels are widely researched for biomedical applications such as drug delivery. The tunable properties of hydrogels, in terms of swelling, mechanical properties and mesh size, make them prime candidates for this application. Synthetic polymers display superior mechanical properties and swelling ability, but their toxicity, and lack of biodegradability and biocompatibility is problematic. Biopolymer hydrogels synthesized with either reduced, or without toxic crosslinker agents, could provide viable alternatives for biomedical applications. </p> <p>This study details the approaches for synthesis of three main hydrogel formulations. The hydrogels were characterized by oscillatory rheological measurements, dynamic swelling, and pulsed gradient spin-echo NMR.</p> <p>Poly(NIPAM-co-AAc) was synthesized by free radical polymerization, using a the redox couple (APS/TEMED) as initiators, and DAT as crosslinker. The hydrogel displayed good mechanical properties. Mass swelling ratio was shown to be greatly influenced by initiator ratio.</p> <p>Self-assembling chitosan (SA-CS) hydrogel was prepared under mild reaction conditions. Crosslinking by Michael addition was performed by mixing of maleimide-modified and thiolated chitosan. Inconclusive results indicated the formation a weak reversible network, as well as a covalently crosslinked network with satisfactory swelling ability and mechanical properties.</p> <p>Chitosan-gelatin hydrogel was dissolved in acetic acid and co-crosslinked by glutaraldehyde and sodium sulfate. Oscillatory rheological measurements indicated a trend between increasing amount of sodium sulfate and decreasing storage modulus. Dissolution in aqueous media and lack of swelling suggests it is an inadequate alternative to poly(NIPAM-co-AAc). </p>
dc.language.isoeng
dc.publisherThe University of Bergen
dc.rightsCopyright the Author. All rights reserved
dc.rights.uri
dc.subject
dc.titleSynthesis and characterization of synthetic and biopolymer hydrogels
dc.typeMaster thesis
dc.type.degreeMasteroppgåve i kjemi
dc.type.courseKJEM399
dc.subject.archivecodeMastergrad
dc.subject.nus752299
dc.type.programMAMN-KJEM
dc.date.updated2019-09-03T22:00:02Z
dc.rights.holderCopyright the Author. All rights reserved
bora.peerreviewedNot peer reviewed
fs.gradepass
fs.unitcode12-31-0


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