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dc.contributor.authorStunes, Astrid Kamilla
dc.contributor.authorWestbroek, Irene
dc.contributor.authorFossmark, Reidar
dc.contributor.authorBerge, Rolf Kristian
dc.contributor.authorReseland, Janne Elin
dc.contributor.authorSyversen, Unni
dc.identifier.citationStunes AK, Westbroek I, Fossmark R, Berge RK, Reseland JE, Syversen U. Skeletal effects of the saturated 3-thia fatty acid tetradecylthioacetic acid in rats. PPAR Research. 2011,2011:436358eng
dc.description.abstractThis study explores the skeletal effects of the peroxisome proliferator activated receptor (PPAR)pan agonist tetradecylthioacetic acid (TTA). Rats, without (Study I) and with ovariectomy (OVX) or sham operation (Study II), were given TTA or vehicle daily for 4 months. Bone markers in plasma, whole body and femoral bone mineral density and content (BMD and BMC), and body composition were examined. Histomorphometric and biomechanical analyses (Study I) and biomechanical and μCT analyses (Study II) of the femur were performed. Normal rats fed TTA had higher femoral BMD and increased total and cortical area in femur compared to controls. The ovariectomized groups had decreased BMD and impaired microarchitecture parameters compared to SHAM. However, the TTA OVX group maintained femoral BMC, trabecular thickness in the femoral head, and cortical volume in the femoral metaphysis as SHAM. TTA might increase BMD and exert a light preventive effect on estrogen-related bone loss in rats.eng
dc.publisherHindawi Publishingeng
dc.rightsAttribution CC BYeng
dc.titleSkeletal effects of the saturated 3-thia fatty acid tetradecylthioacetic acid in ratseng
dc.typeJournal articleeng
dc.rights.holderCopyright 2011 The Authorseng
bora.peerreviewedPeer reviewedeng
dc.type.documentJournal article
dc.relation.journalPPAR Research

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