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dc.contributor.authorLivden, J. K.en_US
dc.contributor.authorNilsen, Runeen_US
dc.contributor.authorMatre, R.en_US
dc.date.accessioned2007-04-14T14:18:13Z
dc.date.available2007-04-14T14:18:13Z
dc.date.issued1989-10eng
dc.PublishedArchives of Dermatological Research 1989 281(6): 392-397
dc.identifier.issn0340-3696
dc.identifier.urihttps://hdl.handle.net/1956/2213
dc.description.abstractAn indirect immunofluorescence technique, using murine monoclonal antibodies (MoAbs) against human IFN- and human IFN- was used to study IFNs in cryostat sections from psoriatic skin lesions. The IFNs were more pronounced in sections from highly active psoriasis than in sections from stationary psoriasis. In highly active psoriatic lesions IFNs- was localized to keratinocytes in stratum basale, to some epidermal dendritic cells, probably Langerhans cells, and to some mononuclear cells in dermis. IFN- was usually not detected in sections from stationary psoriasis. IFN- was localized to stratum corneum, to keratinocytes around microabcesses and to mononuclear cells in the dermal cell infiltrates, predominantly in highly active psoriatic lesions. Both IFN- and IFN- were localized to some endothelial cells in the papillary dermis. The MoAbs did not stain sections from unaffected skin from patients with psoriasis or sections from healthy individuals. The findings indicate that the IFN system in the skin may be of significance in the pathophysiology of psoriasis.en_US
dc.format.extent2047596 byteseng
dc.format.mimetypeapplication/pdfeng
dc.language.isoengeng
dc.publisherSpringer Verlageng
dc.titleIn situ localization of interferons in psoriatic lesionsen_US
dc.typePeer reviewed
dc.typeJournal article
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 1989 Springer-Verlag
dc.identifier.doihttps://doi.org/10.1007/bf00455323
dc.subject.nsiVDP::Medisinske Fag: 700nob


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