Blar i Sars International Centre for Marine Molecular Biology på utgivelsesdato
Viser treff 41-60 av 131
-
Transdifferentiation is a driving force of regeneration in Halisarca dujardini (Demospongiae, Porifera)
(Journal article; Peer reviewed, 2015-08-25)The ability to regenerate is widespread in the animal kingdom, but the regenerative capacities and mechanisms vary widely. To understand the evolutionary history of the diverse regeneration mechanisms, the regeneration ... -
Evolution and development of the adelphophagic, intracapsular Schmidt's larva of the nemertean Lineus ruber
(Journal article; Peer reviewed, 2015-09-28)Background: The life cycle of many animals includes a larval stage, which has diversified into an astonishing variety of ecological strategies. The Nemertea is a group of spiralians that exhibits a broad diversity of larval ... -
Regulation of Nematostella neural progenitors by SoxB, Notch and bHLH genes
(Journal article; Peer reviewed, 2015-10-06)Notch signalling, SoxB and Group A bHLH ‘proneural’ genes are conserved regulators of the neurogenic program in many bilaterians. However, the ancestry of their functions and interactions is not well understood. We address ... -
Assembly and positioning of actomyosin rings by contractility and planar cell polarity
(Journal article; Peer reviewed, 2015-10-21)The actomyosin cytoskeleton is a primary force-generating mechanism in morphogenesis, thus a robust spatial control of cytoskeletal positioning is essential. In this report, we demonstrate that actomyosin contractility and ... -
Ultrastructural correlates of enhanced norepinephrine and neuropeptide y cotransmission in the spontaneously hypertensive rat brain
(Journal article; Peer reviewed, 2015-10-29)The spontaneously hypertensive rat (SHR) replicates many clinically relevant features of human essential hypertension and also exhibits behavioral symptoms of attention-deficit/hyperactivity disorder and dementia. The SHR ... -
Embracing the comparative approach: How robust phylogenies and broader developmental sampling impacts the understanding of nervous system evolution
(Journal article; Peer reviewed, 2015-11-09)Molecular biology has provided a rich dataset to develop hypotheses of nervous system evolution. The startling patterning similarities between distantly related animals during the development of their central nervous system ... -
Evolution of eumetazoan nervous systems: Insights from cnidarians
(Journal article; Peer reviewed, 2015-12-19)Cnidarians, the sister group to bilaterians, have a simple diffuse nervous system. This morphological simplicity and their phylogenetic position make them a crucial group in the study of the evolution of the nervous system. ... -
Posterior eyespots in larval chitons have a molecular identity similar to anterior cerebral eyes in other bilaterians
(Journal article; Peer reviewed, 2015-12-22)Background: Development of cerebral eyes is generally based on fine-tuned networks and closely intertwined with the formation of brain and head. Consistently and best studied in insects and vertebrates, many signaling ... -
Regulatory RNA at the root of animals: dynamic expression of developmental lincRNAs in the calcisponge Sycon ciliatum
(Journal article; Peer reviewed, 2015-12-23)Long non-coding RNAs (lncRNAs) play important regulatory roles during animal development, and it has been hypothesized that an RNA-based gene regulation was important for the evolution of developmental complexity in animals. ... -
The larval nervous system of the penis worm Priapulus caudatus (Ecdysozoa)
(Journal article; Peer reviewed, 2016-01)The origin and extreme diversification of the animal nervous system is a central question in biology. While most of the attention has traditionally been paid to those lineages with highly elaborated nervous systems (e.g. ... -
Development of the aboral domain in Nematostella requires β-catenin and the opposing activities of Six3/6 and Frizzled5/8
(Journal article; Peer reviewed, 2016-03)The development of the oral pole in cnidarians and the posterior pole in bilaterians is regulated by canonical Wnt signaling, whereas a set of transcription factors, including Six3/6 and FoxQ2, controls aboral development ... -
Glypican1/2/4/6 and sulfated glycosaminoglycans regulate the patterning of the primary body axis in the cnidarian Nematostella vectensis
(Journal article; Peer reviewed, 2016-06)Glypicans are members of the heparan sulfate (HS) subfamily of proteoglycans that can function in cell adhesion, cell crosstalk and as modulators of the major developmental signalling pathways in bilaterians. The evolutionary ... -
Owenia fusiformis – a basally branching annelid suitable for studying ancestral features of annelid neural development
(Journal article; Peer reviewed, 2016-06-16)Background Comparative investigations on bilaterian neurogenesis shed light on conserved developmental mechanisms across taxa. With respect to annelids, most studies focus on taxa deeply nested within the annelid tree, ... -
Xenacoelomorpha's significance for understanding bilaterian evolution
(Journal article; Peer reviewed, 2016-08)The Xenacoelomorpha, with its phylogenetic position as sister group of the Nephrozoa (Protostomia + Deuterostomia), plays a key-role in understanding the evolution of bilaterian cell types and organ systems. Current studies ... -
Developmental expression of “germline”- and “sex determination”-related genes in the ctenophore Mnemiopsis leidyi
(Journal article; Peer reviewed, 2016-08-02)Background: An essential developmental pathway in sexually reproducing animals is the specification of germ cells and the differentiation of mature gametes, sperm and oocytes. The “germline” genes vasa, nanos ... -
Expression of segment polarity genes in brachiopods supports a non-segmental ancestral role of engrailed for bilaterians
(Journal article; Peer reviewed, 2016-08-26)The diverse and complex developmental mechanisms of segmentation have been more thoroughly studied in arthropods, vertebrates and annelids—distantly related animals considered to be segmented. Far less is known about the ... -
Molecular regionalization in the compact brain of the meiofaunal annelid Dinophilus gyrociliatus (Dinophilidae)
(Journal article; Peer reviewed, 2016-08-30)Background: Annelida is a morphologically diverse animal group that exhibits a remarkable variety in nervous system architecture (e.g., number and location of longitudinal cords, architecture of the brain). Despite this ... -
Embryonic chirality and the evolution of spiralian left - right asymmetries
(Journal article; Peer reviewed, 2016-12)The group Spiralia includes species with one of the most significant cases of left–right asymmetries in animals: the coiling of the shell of gastropod molluscs (snails). In this animal group, an early event of embryonic ... -
Early evolution of radial glial cells in Bilateria
(Journal article; Peer reviewed, 2017)Bilaterians usually possess a central nervous system, composed of neurons and supportive cells called glial cells. Whereas neuronal cells are highly comparable in all these animals, glial cells apparently differ, and in ... -
Increased taxon sampling reveals thousands of hidden orthologs in flatworms
(Journal article; Peer reviewed, 2017)Gains and losses shape the gene complement of animal lineages and are a fundamental aspect of genomic evolution. Acquiring a comprehensive view of the evolution of gene repertoires is limited by the intrinsic limitations ...