Optimization issues in medical imaging and fiber-tracking
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Fiber tracking is a relatively recent methodology, made possible by access to new highly advanced MR scanners able to produce high-quality diffusion tensor images (DTI), which promises clinicians a possibility to observe the actual trajectories of fibers and the connectivity of the living human brain. Analysis of such data provides clinicians with a unique tool for diagnosing and predicting disease which affect the “wiring” of the brain, such as stroke, tumors, multiple sclerosis and Alzheimer’s disease. The purpose of this PhD thesis has been to explore ways to improve the quality of DTI as well as the accuracy of the fiber tractography which can be estimated from such data. In order to achieve this purpose we have investigated two fundamentally different areas to improve DTI results; data pre-processing and more accurate data descriptors.
Paper A: Journal of Digital Imaging, Bergmann, Ørjan; Christiansen, Oddvar; Lie, Johan and Arvid Lundervold, Shape-Adaptive DCT for Denoising of 3D Scalar and Tensor Valued Images. Preprint version accepted for publication. Copyright 2007 Society for Imaging Informatics in Medicine. Published by Springer New York. The published version is available at: http://dx.doi.org/10.1007/s10278-007-9088-6Paper B: Bergmann, Ørjan and Trond Steihaug, Solving a TRS which has linear inequality constraints. Preprint. Copyright 2007 Bergman et al.Paper C: Computer-Based Medical Systems, 2005. Proceedings. 18th IEEE Symposium on, Bergmann, Ørjan; Lundervold, Arvid; Steihaug, Trond, Generating a synthetic diffusion tensor dataset, pp. 277- 281. Copyright 2005 IEEE. http://dx.doi.org/10.1109/CBMS.2005.58Paper D: MICCAI, LNCS 4191, Bergmann, Ørjan; Kindlmann,Gordon; Lundervold, Arvid; Westin,Carl-Fredrik, Diffusion k-tensor Estimation from Q-ball Imaging using iscretized Principal Axes.published in the proceedings of the Medical Image Computing and Computer-Assisted Intervention (MICCAI), pp. 268–275. Copyright 2006 Springer. Full-text not available due to publisher restrictions. The published version is available at: http://dx.doi.org/10.1007/11866763_33Paper E: Biomedical Imaging: From Nano to Macro, 2007. 4th IEEE International Symposium on, Bergmann, Ørjan; Kindlmann, Gordon; Peled, Sharon; Westin, Carl-Fredrik, Two-tensor Fiber Tractography, pp. 796 – 799. Copyright 2007 IEEE. http://dx.doi.org/10.1109/ISBI.2007.356972