dc.contributor.author | Vesterhus, Mette | en_US |
dc.contributor.author | Haldorsen, Ingfrid S. | en_US |
dc.contributor.author | Ræder, Helge | en_US |
dc.contributor.author | Molven, Anders | en_US |
dc.contributor.author | Njølstad, Pål Rasmus | en_US |
dc.date.accessioned | 2010-01-05T11:29:28Z | |
dc.date.available | 2010-01-05T11:29:28Z | |
dc.date.issued | 2008-09 | eng |
dc.Published | Journal of Clinical Endocrinology and Metabolism 93(9): 3505-3509 | en |
dc.identifier.issn | 0021-972X | |
dc.identifier.uri | https://hdl.handle.net/1956/3716 | |
dc.description.abstract | Context: There are interplays between the endocrine and exocrine pancreas. Werecently reported an increased frequency of exocrine dysfunction in HNF1A-maturity-onset diabetes of the young (MODY3) patients, compared with controls. Reduced pancreatic volume is seen in HNF1B-MODY (MODY5) and diabetes types 1 and 2. Objective: The aim of this study was to investigate whether HNF1A mutation carriers have reduced pancreatic volume or abnormal pancreatic structure and whether any changes are associated with exocrine dysfunction. Methods: Fifteen HNF1A mutation carriers recruited from the Norwegian MODY Registry, 31 subjects with type 1 diabetes, 10 subjects with type 2 diabetes, and 11 controls underwent computed tomography of the pancreas. We measured pancreatic volume and X-ray attenuation. Pancreatic volume index was defined as pancreatic volume divided by body surface area. Results: Pancreatic volume index was reduced in subjects with HNF1A-MODY(34.5 ml/m²; P<0.02) and type 1 diabetes (21.4 ml/m²; P<0.001) as compared with nondiabetic controls (45.7 ml/m²), and was reduced in subjects with diabetes in combination with fecal elastase deficiency (P=0.03). Subjects with type 1 diabetes had smaller pancreatic volume index, compared with HNF1A mutation carriers (P<0.001). Reduced pancreatic volume index was associated with increasing duration of diabetes. Pancreatic X-ray attenuation in HNF1A mutation carriers was not significantly different from that of nondiabetic controls. Conclusions: HNF1A mutation carriers have reduced pancreatic volume but less reduced than in patients with type 1 diabetes. Insulinopenia could explain both the pancreatic volume reduction and the associated pancreatic dysfunction. | en_US |
dc.language.iso | eng | eng |
dc.publisher | The Endocrine Society | eng |
dc.title | Reduced Pancreatic Volume in Hepatocyte Nuclear Factor 1A-Maturity-Onset Diabetes of the Young | en_US |
dc.type | Peer reviewed | |
dc.type | Journal article | |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | The Endocrine Society | |
dc.identifier.doi | https://doi.org/10.1210/jc.2008-0340 | |
dc.identifier.cristin | 358726 | |
dc.subject.nsi | VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Endokrinologi: 774 | nob |