dc.contributor.author | Datiko, Daniel Gemechu | en_US |
dc.contributor.author | Lindtjørn, Bernt | en_US |
dc.date.accessioned | 2011-02-24T13:48:52Z | |
dc.date.available | 2011-02-24T13:48:52Z | |
dc.date.issued | 2009-09-18 | eng |
dc.Published | BMC Public Health 9(348) | en_US |
dc.identifier.issn | 1471-2458 | |
dc.identifier.uri | https://hdl.handle.net/1956/4535 | |
dc.description.abstract | Background: Decentralization of DOTS has increased the number of cured smear-positive tuberculosis (TB) patients. However, the rate of recurrence has increased mainly due to HIV infection. Recurrence rate could be taken as an important measure of long-term success of TB treatment. We aimed to find out the rate of recurrence in smear-positive patients cured under DOTS in southern Ethiopia. Methods: We did a retrospective cohort study on cured smear-positive TB patients who were treated from 1998 to 2006. Recurrence of smear-positive TB was used as an outcome measure. Person-years of observation (PYO) were calculated per 100 PYO from the date of cure to date of interview. Kaplan-Meier and Cox-regression methods were used to determine the survival and the hazard ratio (HR). Results: 368 cured smear-positive TB patients which were followed for 1463 person-years. Of these, 187 patients (50.8%) were men, 277 patients (75.5%) were married, 157 (44.2%) were illiterate, and 152 patients (41.3%) were farmers. 15 of 368 smear-positive patients had recurrence. The rate of recurrence was 1 per 100 PYO (0.01 per annum). Recurrence was not associated with age, sex, occupation, marital status and level of education. Conclusion: High recurrence rate occurred among smear-positive patients cured under DOTS. Further studies are required to identify factors contributing to high recurrence rates to improve disease free survival of TB patients after treatment. | en_US |
dc.language.iso | eng | eng |
dc.publisher | BioMed Central | eng |
dc.rights | Attribution CC BY | eng |
dc.rights.uri | http://creativecommons.org/licenses/by/2.0 | eng |
dc.title | Tuberculosis recurrence in smear-positive patients cured under DOTS in southern Ethiopia: retrospective cohort study | en_US |
dc.type | Peer reviewed | |
dc.type | Journal article | |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Datiko and Lindtjørn | |
dc.rights.holder | Copyright 2008 Datiko and Lindtjørn; licensee BioMed Central | |
dc.identifier.doi | https://doi.org/10.1186/1471-2458-9-348 | |
dc.subject.nsi | VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Communicable diseases: 776 | eng |
dc.subject.nsi | VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Lung diseases: 777 | eng |