Sjögren’s syndrome: studying the disease in mice
Peer reviewed, Journal article
Published version
Permanent lenke
https://hdl.handle.net/1956/5476Utgivelsesdato
2011-06-13Metadata
Vis full innførselSamlinger
Originalversjon
https://doi.org/10.1186/ar3313Sammendrag
Sjögren’s syndrome (SS), a systemic autoimmune disease, is characterized by infl ammation of exocrine tissues accompanied by a signifi cant loss of their secretory function. Clinical symptoms develop late and there are no diagnostic tests enabling early diagnosis of SS. Thus, particularly to study these covert stages, researchers turn to studying animal models where mice provide great freedom for genetic manipulation and testing the eff ect of experimental intervention. The present review summarizes current literature pertaining to both spontaneous and extrinsic-factor induced SS-like diseases in mouse models, discussing advantages and disadvantages related to the use of murine models in SS research.