dc.contributor.author | Fadnes, Lars Thore | en_US |
dc.contributor.author | Jackson, Debra | en_US |
dc.contributor.author | Engebretsen, Ingunn Marie S. | en_US |
dc.contributor.author | Zembe, Wanga | en_US |
dc.contributor.author | Sanders, David | en_US |
dc.contributor.author | Sommerfelt, Halvor | en_US |
dc.contributor.author | Tylleskär, Thorkild | en_US |
dc.date.accessioned | 2012-01-20T12:36:14Z | |
dc.date.available | 2012-01-20T12:36:14Z | |
dc.date.issued | 2011-05-27 | eng |
dc.Published | BMC Public Health 2011, 11:404 | en |
dc.identifier.issn | 1471-2458 | |
dc.identifier.uri | https://hdl.handle.net/1956/5477 | |
dc.description.abstract | Background: Timely vaccination is important to induce adequate protective immunity. We measured vaccination timeliness and vaccination coverage in three geographical areas in South Africa. Methods: This study used vaccination information from a community-based cluster-randomized trial promoting exclusive breastfeeding in three South African sites (Paarl in the Western Cape Province, and Umlazi and Rietvlei in KwaZulu-Natal) between 2006 and 2008. Five interview visits were carried out between birth and up to 2 years of age (median follow-up time 18 months), and 1137 children were included in the analysis. We used Kaplan-Meier time-to-event analysis to describe vaccination coverage and timeliness in line with the Expanded Program on Immunization for the first eight vaccines. This included Bacillus Calmette-Guérin (BCG), four oral polio vaccines and 3 doses of the pentavalent vaccine which protects against diphtheria, pertussis, tetanus, hepatitis B and Haemophilus influenzae type B. Results: The proportion receiving all these eight recommended vaccines were 94% in Paarl (95% confidence interval [CI] 91-96), 62% in Rietvlei (95%CI 54-68) and 88% in Umlazi (95%CI 84-91). Slightly fewer children received all vaccines within the recommended time periods. The situation was worst for the last pentavalent- and oral polio vaccines. The hazard ratio for incomplete vaccination was 7.2 (95%CI 4.7-11) for Rietvlei compared to Paarl. Conclusions: There were large differences between the different South African sites in terms of vaccination coverage and timeliness, with the poorer areas of Rietvlei performing worse than the better-off areas in Paarl. The vaccination coverage was lower for the vaccines given at an older age. There is a need for continued efforts to improve vaccination coverage and timeliness, in particular in rural areas. | en_US |
dc.language.iso | eng | eng |
dc.publisher | BioMed Central | eng |
dc.rights | Attribution CC BY | eng |
dc.rights.uri | http://creativecommons.org/licenses/by/2.0/ | eng |
dc.title | Vaccination coverage and timeliness in three South African areas: a prospective study | en_US |
dc.type | Peer reviewed | |
dc.type | Journal article | |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2011 Fadnes et al; licensee BioMed Central Ltd. | |
dc.identifier.doi | https://doi.org/10.1186/1471-2458-11-404 | |
dc.identifier.cristin | 841071 | |
dc.subject.nsi | VDP::Medical disciplines: 700::Health sciences: 800::Community medicine, Social medicine: 801 | eng |