dc.contributor.author | Mitternacht, Simon | eng |
dc.contributor.author | Berezovsky, Igor N. | eng |
dc.date.accessioned | 2012-11-12T10:07:04Z | |
dc.date.available | 2012-11-12T10:07:04Z | |
dc.date.issued | 2011 | eng |
dc.Published | Protein Engineering, Design and Selection 24(4): 405-409 | eng |
dc.identifier.issn | 1741-0134 | en_US |
dc.identifier.issn | 1741-0126 | en_US |
dc.identifier.uri | https://hdl.handle.net/1956/6173 | |
dc.description.abstract | An important aspect of understanding protein allostery, and of artificial effector design, is the characterization and prediction of substrate- and effector-binding sites. To find binding sites in allosteric enzymes, many of which are oligomeric with allosteric sites at domain interfaces, we devise a local centrality measure for residue interaction graphs, which behaves well for both small/monomeric and large/multimeric proteins. The measure is purely structure based and has a clear geometrical interpretation and no free parameters. It is not biased towards typically catalytic residues, a property that is crucial when looking for non-catalytic effector sites, which are potent drug targets. | en_US |
dc.description.sponsorship | Norwegian Research Council/FUGE II | eng |
dc.language.iso | eng | eng |
dc.publisher | Oxford University Press | en_US |
dc.subject | Allostery | eng |
dc.subject | allosteric regulation | eng |
dc.subject | catalytic sites | eng |
dc.subject | binding sites | eng |
dc.subject | site prediction | eng |
dc.subject | local closeness | eng |
dc.subject | Protein structure | eng |
dc.subject | Enzyme | eng |
dc.subject.ddc | 572.330285 (DDC23 WebDewey) | eng |
dc.subject.ddc | 572.633 (DDC23 WebDewey) | eng |
dc.subject.ddc | 572.744 (DDC23 WebDewey) | eng |
dc.subject.ddc | 003.72 (DDC23 WebDewey) | eng |
dc.title | A geometry-based generic predictor for catalytic and allosteric sites | en_US |
dc.type | Peer reviewed | |
dc.type | Journal article | |
dc.description.version | acceptedVersion | en_US |
dc.rights.holder | Copyright the Author 2010. Published by Oxford University Press. All rights reserved. | en_US |
dc.identifier.doi | https://doi.org/10.1093/protein/gzq115 | |