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dc.contributor.authorJokela, Jounien_US
dc.contributor.authorOftedal, Linnen_US
dc.contributor.authorHerfindal, Larsen_US
dc.contributor.authorPermi, Perttuen_US
dc.contributor.authorWahlsten, Mattien_US
dc.contributor.authorDøskeland, Stein Oveen_US
dc.contributor.authorSivonen, Kaarinaen_US
dc.date.accessioned2013-04-08T13:59:54Z
dc.date.available2013-04-08T13:59:54Z
dc.date.issued2012-07-19eng
dc.PublishedPLoS ONE 7(7): e41222eng
dc.identifier.issn1932-6203
dc.identifier.urihttps://hdl.handle.net/1956/6492
dc.description.abstractTwo novel cyclic lipopeptides, anabaenolysin A and anabaenolysin B, were isolated from two benthic cyanobacterial strains of the genus Anabaena. This novel class of cyanobacterial lipopeptides has a general structure of a small peptide ring consisting of four amino acids from which two are proteinogenic and two unusual; glycine1, glycine2, 2-(3-amino-5-oxytetrahydrofuran-2-yl)-2-​hydroxyaceticacid3 and a long unsaturated C18 β-amino acid4 with a conjugated triene structure. They are distinguished by the presence of a conjugated dienic structure in the C18 β-amino acid present in anabaenolysin A but not in anabaenolysin B. Conjugated triene structure generates a typical UV spectrum for anabaenolysins for easy recognition. Anabaenolysin A constituted up to 400 ppm of the cyanobacterial dry weight. We found evidence of thirteen variants of anabaenolysins in one cyanobacterial strain. This suggests that the anabaenolysins are an important class of secondary metabolites in benthic Anabaena cyanobacteria. Both anabaenolysin A and B had cytolytic activity on a number of mammalian cell lines.en_US
dc.language.isoengeng
dc.publisherPublic Library of Scienceeng
dc.rightsAttribution CC BYeng
dc.rights.urihttp://creativecommons.org/licenses/by/2.5/eng
dc.titleAnabaenolysins, Novel Cytolytic Lipopeptides from Benthic Anabaena Cyanobacteriaen_US
dc.typePeer reviewed
dc.typeJournal article
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2012 Jokela et al.
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0041222
dc.identifier.cristin937298


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