dc.contributor.author | Gregersen, Kine | en_US |
dc.contributor.author | Valeur, Jørgen | en_US |
dc.contributor.author | Lillestøl, Kristine | en_US |
dc.contributor.author | Frøyland, Livar | en_US |
dc.contributor.author | Araujo, Pedro | en_US |
dc.contributor.author | Lied, Gülen Arslan | en_US |
dc.contributor.author | Berstad, Arnold | en_US |
dc.date.accessioned | 2013-06-23T13:49:32Z | |
dc.date.available | 2013-06-23T13:49:32Z | |
dc.date.issued | 2011-08 | eng |
dc.Published | International Journal of General Medicine 4: 555-560 | eng |
dc.identifier.issn | 1178-7074 | |
dc.identifier.uri | https://hdl.handle.net/1956/6719 | |
dc.description.abstract | Background: Food hypersensitivity is commonly suspected, but seldom verified. Patients with subjective food hypersensitivity suffer from both intestinal and extraintestinal health complaints. Abnormalities of the enterochromaffin cells may play a role in the pathogenesis. The aim of this study was to investigate enterochromaffin cell function in patients with subjective food hypersensitivity by measuring serum chromogranin A (CgA) and 5-hydroxytryptamine (5-HT, serotonin) in gut lavage fluid. Methods: Sixty-nine patients with subjective food hypersensitivity were examined. Twenty-three patients with inflammatory bowel disease and 35 healthy volunteers were included as comparison groups. CgA was measured in serum by enzyme-linked immunosorbent assay. Gut lavage fluid was obtained by administering 2 L of polyethylene glycol solution intraduodenally. The first clear fluid passed per rectum was collected and 5-HT was analyzed by liquid chromatography tandem mass spectrometry. Results: Serum levels of CgA were significantly lower in patients with subjective food hypersensitivity than in healthy controls (P 0.04). No differences were found in 5-HT levels in gut lavage fluid between patients with subjective food hypersensitivity and the control groups. There was no correlation between serum CgA and gut lavage 5-HT. Conclusion: Decreased blood levels of CgA suggest neuroendocrine alterations in patients with subjective food hypersensitivity. However, 5-HT levels in gut lavage fluid were normal. | en_US |
dc.language.iso | eng | eng |
dc.publisher | Dove Medical Press | eng |
dc.relation.ispartof | <a href="http://hdl.handle.net/1956/6720" target="blank">Subjective food hypersensitivity</a> | eng |
dc.rights | Attribution CC BY | eng |
dc.rights.uri | http://creativecommons.org/licenses/by/2.5/ | eng |
dc.title | Subjective food hypersensitivity: assessment of enterochromaffin cell markers in blood and gut lavage fluid | en_US |
dc.type | Peer reviewed | |
dc.type | Journal article | |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2011 Gregersen et al, publisher and licensee Dove Medical Press Ltd. | |
dc.identifier.doi | https://doi.org/10.2147/ijgm.s18349 | |
dc.source.journal | International Journal of General Medicine | |