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dc.contributor.authorAurlien, Dageng
dc.date.accessioned2013-08-20T10:21:30Z
dc.date.available2013-08-20T10:21:30Z
dc.date.issued2013-05-31eng
dc.identifier.isbn978-82-308-2253-1eng
dc.identifier.urihttp://hdl.handle.net/1956/6959
dc.description.abstract<p><strong>Purpose:</strong> Based on a clinical observation, this study was initiated to examine whether treatment with lamotrigine (LTG) is associated with an increased risk of sudden unexpected death in epilepsy (SUDEP) in sub-groups of epilepsy patients, and to explore the underlying causes of the increased mortality rate in the epilepsy population.</p> <p><strong>Materials and methods:</strong> A nested case-control study of SUDEP in Rogaland county, Norway was conducted by review of post mortem reports, data from the Norwegian Cause of Death Registry, and hospital records. We also examined twenty-six newly diagnosed epilepsy patients by signal-averaged and standard electrocardiography. Fifteen patients were treated with LTG and ten with carbamazepine (CBZ). Furthermore the causes of death (COD) of deceased epilepsy patients at Stavanger University Hospital were compared with the COD in the general population.</p> <p><strong>Results:</strong> The incidence of SUDEP was significantly elevated in females on LTG, and a significantly higher proportion of female SUDEP victims were on LTG compared with controls. No significant electrocardiographic abnormalities were detected in the 25 patients that completed the study. A significantly lower proportion of deceased epilepsy patients had died from cardiac disease compared with the general population. In a significant proportion of cases, the onset of the disorder leading to death had preceded the onset of epilepsy.</p> <p><strong>Conclusions:</strong> Treatment with LTG in females was significantly associated with SUDEP. However, it remains uncertain whether a causal relationship is present. We found no evidence of cardiac abnormalities caused by LTG or CBZ. Comorbid and underlying disorders were the main determinants of mortality in the epilepsy population.</p>eng
dc.language.isoengeng
dc.publisherThe University of Bergeneng
dc.relation.haspart<strong>Paper I:</strong> Aurlien D., Taubøll E., Gjerstad L. (2007) Lamotrigine in idiopathic epilepsy - increased risk of cardiac death? Acta Neurol Scand 115:199-203. Full-text not available in BORA. The published version is available at: <a href="http://dx.doi.org/10.1111/j.1600-0404.2006.00730.x" target="blank">http://dx.doi.org/10.1111/j.1600-0404.2006.00730.x</a>eng
dc.relation.haspart<strong>Paper II:</strong> Aurlien D., Leren T.P., Taubøll E., Gjerstad L. (2009) New SCN5A mutation in a SUDEP victim with idiopathic epilepsy. Seizure 18:158-60. Full-text not available in BORA. The published version is available at: <a href="http://dx.doi.org/10.1016/j.seizure.2008.07.008" target="blank"> http://dx.doi.org/10.1016/j.seizure.2008.07.008</a>eng
dc.relation.haspart<strong>Paper III:</strong> Aurlien D., Larsen J.P., Gjerstad L., Taubøll E. (2012) Increased risk of sudden unexpected death in epilepsy in females using lamotrigine: a nested, case-control study. Epilepsia 53:258-66. Full-text not available in BORA. The published version is available at: <a href="http://dx.doi.org/10.1111/j.1528-1167.2011.03334.x" target="blank"> http://dx.doi.org/10.1111/j.1528-1167.2011.03334.x</a>eng
dc.relation.haspart<strong>Paper IV:</strong> Svalheim S., Aurlien D., Amlie J.P., Gjerstad L., Taubøll E. (2012) Signal-averaged and standard electrocardiography in patients with newly diagnosed epilepsy. Epilepsy & Behavior 25:543-545. Full-text not available in BORA. The published version is available at: <a href="http://dx.doi.org/10.1016/j.yebeh.2012.09.023" target="blank"> http://dx.doi.org/10.1016/j.yebeh.2012.09.023</a>eng
dc.relation.haspart<strong>Paper V:</strong> Aurlien D., Larsen J.P., Gjerstad L., Taubøll E. (2012) Comorbid and underlying diseases - major determinants of excess mortality in epilepsy. Seizure 21:573-7. Full-text not available in BORA. The published version is available at: <a href="http://dx.doi.org/10.1016/j.seizure.2012.05.015" target="blank">http://dx.doi.org/10.1016/j.seizure.2012.05.015</a>eng
dc.subjectepilepsyeng
dc.subjectMortalityeng
dc.subjectSUDEPeng
dc.subjectsuddeneng
dc.subjectdeatheng
dc.subjectlamotrigineeng
dc.titleMortality in epilepsy and the influence of comorbid conditions and antiepileptic drugseng
dc.typeDoctoral thesiseng
dc.rights.holderCopyright the author. All rights reserved
bora.peerreviewedPeer reviewedeng
dcterms.hasParthttp://dx.doi.org/10.1111/j.1600-0404.2006.00730.x
dcterms.hasParthttp://dx.doi.org/10.1016/j.seizure.2008.07.008
dcterms.hasParthttp://dx.doi.org/10.1111/j.1528-1167.2011.03334.x
dcterms.hasParthttp://dx.doi.org/10.1016/j.yebeh.2012.09.023
dcterms.hasParthttp://dx.doi.org/10.1016/j.seizure.2012.05.015


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