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  • Circulating concentrations of biomarkers and metabolites related to Vitamin status, one-carbon and the kynurenine pathways in US, Nordic, Asian, and Australian populations 

    Midttun, Øivind; Theofylaktopoulou, Despoina; Mccann, Adrian; Fanidi, Anouar; Muller, David C.; Meyer, Klaus; Ulvik, Arve; Zheng, Wei; Shu, Xiao-Ou; Xiang, Yong-Bing; Prentice, Ross; Thomson, Cynthia A.; Pettinger, Mary; Giles, Graham G.; Hodge, Allison; Cai, Qiuyin; Blot, William J.; Wu, Jie; Johansson, Mikael; Hultdin, Johan; Grankvist, Kjell; Stevens, Victoria L.; McCullough, Marjorie L.; Weinstein, Stephanie J.; Albanes, Demetrius; Langhammer, Arnulf; Hveem, Kristian; Næss, Marit; Sesso, Howard D.; Gaziano, J. Michael; Buring, Julie E.; Lee, I-Min; Severi, Gianluca; Zhang, Xuehong; Han, Jiali; Stampfer, Meir J.; Smith-Warner, Stephanie A.; Zeleniuch-Jacquotte, Anne; Le Marchand, Loic; Yuan, Jian-Min; Butler, Lesley M.; Koh, Woon-Puay; Wang, Renwei; Gao, Yu-Tang; Ericson, Ulrika; Sonestedt, Emily; Ziegler, Regina G.; Freedman, Neal D.; Visvanathan, Kala; Jones, Miranda R.; Relton, Caroline; Brennan, Paul; Johansson, Mattias; Ueland, Per Magne (Oxford University Press, 2017-06)
    Background: Circulating concentrations of biomarkers that are related to vitamin status vary by factors such as diet, fortification, and supplement use. Published biomarker concentrations have also been influenced by the ...
    Journal article
  • Identification of shared genetic variants between schizophrenia and lung cancer 

    Zuber, Verena; Jönsson, Erik Gunnar; Frei, Oleksandr; Witoelar, Aree; Thompson, V K; Schork, Andrew J; Bettella, Francesco; Wang, Yunpeng; Djurovic, Srdjan; Smeland, Olav Bjerkehagen; Dieset, Ingrid; Fanous, Ayman H.; Desikan, Rahul S; Küry, Sébastien; Bezieau, Stephane; Dale, Anders M; Mills, Ian Geoffrey; Andreassen, Ole Andreas (Nature Publishing Group, 2018-01-12)
    Epidemiology studies suggest associations between schizophrenia and cancer. However, the underlying genetic mechanisms are not well understood, and difficult to identify from epidemiological data. We investigated if there ...
    Journal article
  • Oral microbiota in autoimmune polyendocrine syndrome type 1 

    Bruserud, Øyvind; Siddiqui, Huma; Marthinussen, Michaela Cuida; Chen, Tsute; Jonsson, Roland; Oftedal, Bergithe Eikeland; Olsen, Ingar; Husebye, Eystein Sverre; Wolff, Anette Bøe (Taylor & Francis, 2018)
    Background: Autoimmune polyendocrine syndrome type-1 (APS-1) is a rare, childhood onset disease caused by mutations in the Autoimmune Regulator gene. The phenotypic expression is highly variable and includes disease ...
    Journal article
  • HIV-infected persons with type 2 diabetes show evidence of endothelial dysfunction and increased inflammation 

    Hove-Skovsgaard, Malene; Gaardbo, Julie Christine; Kolte, Lilian; Winding, Kamilla; Seljeflot, Ingebjørg; Svardal, Asbjørn M.; Berge, Rolf Kristian; Gerstoft, Jan; Ullum, Henrik; Trøseid, Marius; Nielsen, Susanne Dam (BioMed Central, 2017-03-29)
    Background: Increased incidence of cardiovascular diseases (CVD) in both HIV infection and type 2 diabetes (T2D) compared to the general population has been described. Little is known about the combined effect of HIV ...
    Journal article
  • Boosting of cross-reactive and protection-associated T cells in children after live attenuated influenza vaccination 

    Mohn, Kristin Greve Isdahl; Zhou, Fan; Brokstad, Karl Albert; Sridhar, Saranya; Cox, Rebecca Jane (Oxford University Press, 2017-05)
    Background. Live attenuated influenza vaccines (LAIVs) stimulate a multifaceted immune response including cellular immunity, which may provide protection against newly emerging strains. This study shows proof of concept ...
    Journal article
  • T cell receptor assessment in autoimmune disease requires access to the most adjacent immunologically active organ 

    Oftedal, Bergithe Eikeland; Ardesjo Lundgren, Brita; Hamm, David; Gan, Poh-Yi; Holdsworth, Stephen R; Hahn, Christopher N.; Schreiber, Andreas W.; Scott, Hamish S. (Elsevier, 2017-07)
    Next generation sequencing of T and B cell receptors is emerging as a valuable and effective method to diagnose and monitor hematopoietic malignancies. So far, this approach has not been fully explored in regard to autoimmune ...
    Journal article
  • CDC25 inhibition in acute myeloid leukemia - A study of patient heterogeneity and the effects of different inhibitors 

    Brenner, Annette; Reikvam, Håkon; Rye, Kristin Paulsen; Hagen, Karen Marie; Lavecchia, Antonio; Bruserud, Øystein (MDPI, 2017-03-11)
    Cell division cycle 25 (CDC25) protein phosphatases regulate cell cycle progression through the activation of cyclin-dependent kinases (CDKs), but they are also involved in chromatin modulation and transcriptional regulation. ...
    Journal article
  • Sarcopenia in patients with hip fracture. A multicenter prospective study with one-year follow-up 

    Steihaug, Ole Martin (The University of Bergen, 2018-09-11)
    Sarcopenia is a geriatric syndrome of reduced muscle mass and physical performance associated with falls, fractures, impairments in activities of daily living, and mortality. Hip fractures are fractures of the upper third ...
    Doctoral thesis
  • Late-week surgical treatment of endometrial cancer is associated with worse long-term outcome: Results from a prospective, multicenter study 

    Njølstad, Tormund Salvesen; Werner, Henrica Maria Johanna; Marcickiewicz, Janusz; Tingulstad, Solveig; Staff, Anne Cathrine; Oddenes, Klaus; Bjørge, Line; Engh, Marie Ellström; Woie, Kathrine; Tjugum, Jostein; Lode, Margaret Sævik; Amant, Frédéric; Salvesen, Helga; Trovik, Jone (PLOS, 2017-08-03)
    Surgery is the cornerstone in primary endometrial cancer treatment, and with curative intent it constitutes total hysterectomy and bilateral salpingo-oopherectomy. In addition, lymphadenectomy is performed in selected ...
    Journal article
  • Peripheral blood stem cell mobilization in healthy Donors by granulocyte colony-stimulating factor causes preferential mobilization of lymphocyte subsets 

    Melve, Guro Kristin; Ersvær, Elisabeth; Eide, Geir Egil; Kristoffersen, Einar Klæboe; Bruserud, Øystein (Frontiers, 2018-05-02)
    Background: Allogeneic hematopoietic stem cell transplantation is associated with a high risk of immune-mediated post-transplant complications. Graft depletion of immunocompetent cell subsets is regarded as a possible ...
    Journal article
  • Causal Analysis of World Health Organization's Surgical Safety Checklist Implementation Quality and Impact on Care Processes and Patient Outcomes: Secondary Analysis From a Large Stepped Wedge Cluster Randomized Controlled Trial in Norway 

    Haugen, Arvid Steinar; Wæhle, Hilde Valen; Almeland, Stian Kreken; Harthug, Stig; Sevdalis, Nick; Eide, Geir Egil; Nortvedt, Monica Wammen; Smith, Ingrid; Softeland, Eirik (Wolters Kluwer, 2017)
    Objective: We hypothesize that high-quality implementation of the World Health Organization's Surgical Safety Checklist (SSC) will lead to improved care processes and subsequently reduction of peri- and postoperative ...
    Journal article
  • Bones, blood and steel: How bioelectrical impedance analysis is affected by hip fracture and surgical implants 

    Steihaug, Ole Martin; Bogen, Bård Erik; Kristoffersen, Målfrid Holen; Ranhoff, Anette Hylen (Journal of Electrical Bioimpedance, 2017)
    Introduction: Bioelectrical impedance analysis (BIA) is in widespread use, but there is uncertainty about its validity in patients with metal implants or after acute hip fracture and surgery. We aimed to investigate the ...
    Journal article
  • Single cell immune profiling by mass cytometry of newly diagnosed chronic phase chronic myeloid leukemia treated with nilotinib 

    Gullaksen, Stein-Erik; Skavland, Jørn; Gavasso, Sonia; Tosevski, Vinko; Warzocha, Krzysztof; Dumrese, Claudia; Ferrant, Augustin; Gedde-Dahl, Thobias; Hellmann, Andrzej; Janssen, Jeroen; Labar, Boris; Lang, Alois; Majeed, Mohammed Waleed; Mihaylov, Georgi; Stentoft, Jesper; Stenke, Leif; Thaler, Josef; Thielen, Noortje; Verhoef, Gregor; Voglova, Jaroslava; Ossenkoppele, Gert; Hochhaus, Andreas; Hjorth-Hansen, Henrik; Mustjoki, Satu; Sopper, Sieghart; Giles, Francis; Porkka, Kimmo; Wolf, Dominik; Gjertsen, Bjørn Tore (Ferrata Storti Foundation, 2017-08)
    Monitoring of single cell signal transduction in leukemic cellular subsets has been proposed to provide deeper understanding of disease biology and prognosis, but has so far not been tested in a clinical trial of targeted ...
    Journal article
  • A simple algorithm for the identification of clinical COPD phenotypes 

    Burgel, Pierre-Régis; Paillasseur, Jean-Louis; Janssens, Wim; Piquet, Jacques; Ter Riet, Gerben; Garcia-Aymerich, Judith; Cosio, Borja; Bakke, Per S.; Puhan, Milo A.; Langhammer, Arnulf; Alfageme, Inmaculada; Almagro, Pere; Ancochea, Julio; Celli, Bartolomé R.; Casanova, Ciro; de-Torres, Juan P.; Decramer, Marc; Echazarreta, Andrés; Esteban, Cristobal; Punter, Rosa Mar Gomez; Han, Meilan K.; Johannessen, Ane; Kaiser, Bernhard; Lamprecht, Bernd; Lange, Peter; Leivseth, Linda; Marin, Jose M.; Martin, Francis; Martinez-Camblor, Pablo; Miravitlles, Marc; Oga, Toru; Ramírez, Ana Sofia; Sin, Don D.; Sobradillo, Patricia; Soler-Cataluña, Juan J.; Turner, Alice M.; Rivera, Francisco Javier Verdu; Soriano, Joan B.; Roche, Nicolas (ERS, 2017)
    This study aimed to identify simple rules for allocating chronic obstructive pulmonary disease (COPD) patients to clinical phenotypes identified by cluster analyses. Data from 2409 COPD patients of French/Belgian COPD ...
    Journal article
  • Emergence of a Streptococcus dysgalactiae subspecies equisimilis stG62647-lineage associated with severe clinical manifestations 

    Oppegaard, Oddvar; Mylvaganam, Haima; Skrede, Steinar; Lindemann, Paul Christoffer; Kittang, Bård Reiakvam (Nature Publishing Group, 2017-08-08)
    Increasing incidence rates of invasive Streptococcus dysgalactiae subspecies equisimilis (SDSE) infections have been reported worldwide, but the evolutionary mechanisms underlying this development remain elusive. Through ...
    Journal article
  • Timing of menarche in Norwegian girls: Associations with body mass index, waist circumference and skinfold thickness 

    Bratke, Heiko; Bruserud, Ingvild Særvold; Brannsether-Ellingsen, Bente; Assmus, Jörg; Bjerknes, Robert; Roelants, Mathieu; Juliusson, Petur Benedikt (BioMed Central, 2017-06-06)
    Background: Research studies show conflicting results regarding the association between menarche and body weight. The purpose of the present study was to investigate if anthropometric indicators of body composition, body ...
    Journal article
  • Novel transcriptional signatures for sputum-independent diagnostics of tuberculosis in children 

    Gjøen, John Espen; Jenum, Synne; Sivakumaran, Dhanasekaran; Mukherjee, Aparna; MacAden, Ragini; Kabra, Sushil K.; Lodha, Rakesh; Ottenhoff, Tom H.M.; Haks, Marielle C.; Doherty, Timothy Mark; Ritz, Christian; Grewal, Harleen (Nature Publishing Group, 2017-07-19)
    Pediatric tuberculosis (TB) is challenging to diagnose, confirmed by growth of Mycobacterium tuberculosis at best in 40% of cases. The WHO has assigned high priority to the development of non-sputum diagnostic tools. We ...
    Journal article
  • Does sarcopenia predict change in mobility after hip fracture? A multicenter observational study with one-year follow-up 

    Steihaug, Ole Martin; Ranhoff, Anette Hylen; Gjesdal, Clara Gram; Bogen, Bård Erik; Lien, Gunhild; Kristoffersen, Målfrid Holen; Hufthammer, Karl Ove (BioMed Central, 2018-03-05)
    Background: Patients with hip fracture frequently have sarcopenia and are at great risk of loss of mobility. We have investigated if sarcopenia predicts change in mobility after hip fracture. Methods: This is a prospective, ...
    Journal article
  • Comparing microbiota profiles in induced and spontaneous sputum samples in COPD patients 

    Tangedal, Solveig; Aanerud, Marianne; Grønseth, Rune; Drengenes, Christine; Wiker, Harald G; Bakke, Per S.; Eagan, Tomas Mikal (BioMed Central, 2017-08-29)
    Background: Induced and spontaneous sputum are used to evaluate the airways microbiota. Whether the sputum types can be used interchangeably in microbiota research is unknown. Our aim was to compare microbiota in induced ...
    Journal article
  • Altered immune activation and IL-23 signaling in response to Candida albicans in autoimmune polyendocrine syndrome type 1 

    Bruserud, Øyvind; Bratland, Eirik; Hellesen, Alexander; Delaleu, Nicolas; Reikvam, Håkon; Oftedal, Bergithe Eikeland; Wolff, Anette Susanne Bøe (Frontiers, 2017-09-01)
    Objective: Autoimmune polyendocrine syndrome type 1 (APS-1) is a rare, childhood onset disease caused by mutations in the autoimmune regulator (AIRE) gene. Chronic mucocutaneous candidiasis (CMC) is one of the three major ...
    Journal article

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