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  • Role of rare HNF1A variants function in monogenic and type 2 diabetes 

    Najmi, Laeya Abdoli (The University of Bergen, 2018-10-26)
    Variants in the transcription factor gene HNF1A have been identified in subjects with maturity-onset diabetes of the young (MODY) type 3, type 2 diabetes, as well as in children with apparent type 1 diabetes. One of the ...
    Doctoral thesis
  • Association of a Low-Frequency Variant in HNF1A With Type 2 Diabetes in a Latino Population 

    Estrada, Karol; Aukrust, Ingvild; Bjørkhaug, Lise; Najmi, Laeya Abdoli; Njølstad, Pål Rasmus; MacArthur, Daniel G.; The SIGMA Type 2 Diabetes Consortium (American Medical Association, 2014-06)
    Importance: Latino populations have one of the highest prevalences of type 2 diabetes worldwide. Objectives: To investigate the association between rare protein-coding genetic variants and prevalence of type 2 diabetes ...
    Journal article
  • Preclinical models and molecular biomarkers. Tools to improve treatment in endometrial carcinoma 

    Fonnes, Tina (The University of Bergen, 2018-11-30)
    Background: Endometrial carcinoma is the fourth most common cancer in European women, and incidence is increasing. No major improvements in treatment or survival have been achieved over the last decades, and an individualized ...
    Doctoral thesis
  • Multimodal Imaging of Orthotopic Mouse Model of Endometrial Carcinoma 

    Haldorsen, Ingfrid S.; Popa, Mihaela Lucia; Fonnes, Tina; Brekke, Njål; Kopperud, Reidun Kristin; Visser, Nicole C.; Rygh, Cecilie Brekke; Pavlin, Tina; Salvesen, Helga Birgitte; McCormack, Emmet; Krakstad, Camilla (Public Library of Science, 2015-08-07)
    Background: Orthotopic endometrial cancer models provide a unique tool for studies of tumour growth and metastatic spread. Novel preclinical imaging methods also have the potential to quantify functional tumour ...
    Journal article
  • Distinct T and NK cell populations may serve as immune correlates of protection against symptomatic pandemic influenza A(H1N1) virus infection during pregnancy 

    Savic, Miloje; Dembinski, Jennifer Lynn; Laake, Ida; Hungnes, Olav; Cox, Rebecca Jane; Oftung, Fredrik; Trogstad, Lill; Mjaaland, Siri (PLOS, 2017-11-16)
    Maternal influenza infection during pregnancy is associated with increased risk of morbidity and mortality. However, the link between the anti-influenza immune responses and health-related risks during infection is not ...
    Journal article
  • Left Vocal Cord Paralysis After Patent Ductus Arteriosus Ligation: A Systematic Review. 

    Engeseth, Merete Salveson; Olsen, Nina Rydland; Mæland, Silje; Halvorsen, Thomas; Goode, Adam; Røksund, Ola Drange (Elsevier, 2018)
    Context: Extremely premature (EP) infants are at increased risk of left vocal cord paralysis (LVCP) following surgery for patent ductus arteriosus (PDA). Objective: A Systematical Review was conducted to investigate the ...
    Journal article
  • Parents’ Attitudes toward Clinical Genetic Testing for Autism Spectrum Disorder—Data from a Norwegian Sample 

    Johannessen, Tor Jarle; Nærland, Terje; Hope, Sigrun; Torske, Tonje; Høyland, Anne Lise; Strohmaier, Jana; Heiberg, Arvid; Rietschel, Marcella; Djurovic, Srdjan; Andreassen, Ole Andreas (MDPI, 2017-05-18)
    Clinical genetic testing (CGT) of children with autism spectrum disorder (ASD) may have positive and negative effects. Knowledge about parents’ attitudes is needed to ensure good involvement of caregivers, which is crucial ...
    Journal article
  • Genetic variation in 117 myelination-related genes in schizophrenia: Replication of association to lipid biosynthesis genes 

    Stokowy, Tomasz; Polushina, Tatiana; Sønderby, Ida Elken; Karlsson, Robert; Giddaluru, Sudheer; Le Hellard, Stephanie; Bergen, Sarah E; Sullivan, Patrick F; Andreassen, Ole Andreas; Djurovic, Srdjan; Hultman, Christina M.; Steen, Vidar Martin (Nature Publishing Group, 2018-05-02)
    Schizophrenia is a serious psychotic disorder with high heritability. Several common genetic variants, rare copy number variants and ultra-rare gene-disrupting mutations have been linked to disease susceptibility, but there ...
    Journal article
  • Paternal and maternal obesity but not gestational weight gain is associated with type 1 diabetes 

    Magnus, Maria Christine; Olsen, Sjurdur Frodi; Granström, Charlotta; Lund-Blix, Nicolai Andre; Svensson, Jannet; Johannesen, Jesper; Fraser, Abigail; Skrivarhaug, Torild; Joner, Geir; Njølstad, Pål Rasmus; Størdal, Ketil; Stene, Lars Christian Mørch (Oxford University Press, 2018-04)
    Background Our objective was to examine the associations of parental body mass index (BMI) and maternal gestational weight gain with childhood-onset type 1 diabetes. Comparing the associations of maternal and paternal BMI ...
    Journal article
  • Primary aldosteronism in Western Norway. Studies of diagnostic approach and treatment outcome 

    Grytaas, Marianne Aardal (The University of Bergen, 2018-09-06)
    Primary aldosteronism (PA) is the most common cause of secondary hypertension (HT), accounting for 5 to 12% of all hypertensive individuals. Patients with PA experience increased cardiovascular, renal and metabolic ...
    Doctoral thesis
  • Cardiac magnetic resonance imaging of myocardial mass and fibrosis in primary aldosteronism 

    Grytaas, Marianne; Sellevåg, Kjersti; Thordarson, Hrafnkell B; Husebye, Eystein Sverre; Løvås, Kristian; Larsen, Terje H (Bioscientifica, 2018-03)
    Background: Primary aldosteronism (PA) is associated with increased cardiovascular morbidity, presumably due to left ventricular (LV) hypertrophy and fibrosis. However, the degree of fibrosis has not been extensively ...
    Journal article
  • Transcapillary fluid balance in children. Methodology and new clinical studies. To the interstitial space - and back again 

    Guthe, Hans Jørgen Timm (The University of Bergen, 2016-04-29)
    Objective: The capillaries represent a semipermeable barrier between the blood and the interstitium, where there is a continuous exchange of fluid and solutes. Numerous factors affect the tight regulation of this movement ...
    Doctoral thesis
  • Transcapillary fluid flux and inflammatory response during neonatal therapeutic hypothermia: an open, longitudinal, observational study 

    Guthe, Hans Jørgen Timm; Nedrebø, Torbjørn; Damås, Jan Kristian; Wiig, Helge; Berg, Ansgar (BioMed Central, 2018-02-23)
    Background: Therapeutic hypothermia is neuroprotective in asphyxiated neonates by counteracting mechanisms contributing to brain injury. Although an initial increased permeability is part of an inflammatory reaction ...
    Journal article
  • Limited Benefit of Fish Consumption on Risk of Hip Fracture among Men in the Community-Based Hordaland Health Study 

    Rosendahl-Riise, Hanne; Sulo, Gerhard; Karlsson, Therese; Drevon, Christian A.; Dierkes, Jutta; Tell, Grethe S. (MDPI, 2018-07-06)
    Hip fractures have a high prevalence worldwide. Few studies have investigated whether fish consumption is associated with risk of hip fractures. The objective of the present study was to investigate the effect of fish ...
    Journal article
  • Dietary predictors of bone mineral density, hip fractures, mobility and muscle strength - in community-dwelling older persons 

    Rosendahl-Riise, Hanne (The University of Bergen, 2018-10-23)
    Background: The aging process involves decline of both muscle and bone mass. The loss of muscle mass is associated with decreased muscle strength and mobility, while loss of bone mass leads to osteoporosis and increased ...
    Doctoral thesis
  • An evolutionary epigenetics approach to schizophrenia 

    Banerjee, Niladri (The University of Bergen, 2018-09-28)
    Schizophrenia is a psychotic disorder with an estimated lifetime prevalence of ~1% worldwide. Despite reduced fecundity of patients, this rate is stable across population groups separated by geography and time. There is ...
    Doctoral thesis
  • Recently evolved human-specific methylated regions are enriched in schizophrenia signals 

    Banerjee, Niladri; Polushina, Tatiana; Bettella, Francesco; Giddaluru, Sudheer; Steen, Vidar Martin; Andreassen, Ole Andreas; Le Hellard, Stephanie (BioMed Central, 2018)
    Background: One explanation for the persistence of schizophrenia despite the reduced fertility of patients is that it is a by-product of recent human evolution. This hypothesis is supported by evidence suggesting that ...
    Journal article
  • In vitro characterization of six STUB1 variants in spinocerebellar ataxia 16 reveals altered structural properties for the encoded CHIP proteins 

    Pakdaman, Yasaman; Sanchez Guixe, Monica; Kleppe, Rune; Erdal, Sigrid; Bustad, Helene J.; Bjørkhaug, Lise; Haugarvoll, Kristoffer; Tzoulis, Charalampos; Heimdal, Ketil Riddervold; Knappskog, Per; Johansson, Stefan; Aukrust, Ingvild (Portland Press, 2017)
    Spinocerebellar ataxia, autosomal recessive 16 (SCAR16) is caused by biallelic mutations in the STIP1 homology and U-box containing protein 1 (STUB1) gene encoding the ubiquitin E3 ligase and dimeric co-chaperone C-terminus ...
    Journal article
  • Circulating concentrations of biomarkers and metabolites related to Vitamin status, one-carbon and the kynurenine pathways in US, Nordic, Asian, and Australian populations 

    Midttun, Øivind; Theofylaktopoulou, Despoina; Mccann, Adrian; Fanidi, Anouar; Muller, David C.; Meyer, Klaus; Ulvik, Arve; Zheng, Wei; Shu, Xiao-Ou; Xiang, Yong-Bing; Prentice, Ross; Thomson, Cynthia A.; Pettinger, Mary; Giles, Graham G.; Hodge, Allison; Cai, Qiuyin; Blot, William J.; Wu, Jie; Johansson, Mikael; Hultdin, Johan; Grankvist, Kjell; Stevens, Victoria L.; McCullough, Marjorie L.; Weinstein, Stephanie J.; Albanes, Demetrius; Langhammer, Arnulf; Hveem, Kristian; Næss, Marit; Sesso, Howard D.; Gaziano, J. Michael; Buring, Julie E.; Lee, I-Min; Severi, Gianluca; Zhang, Xuehong; Han, Jiali; Stampfer, Meir J.; Smith-Warner, Stephanie A.; Zeleniuch-Jacquotte, Anne; Le Marchand, Loic; Yuan, Jian-Min; Butler, Lesley M.; Koh, Woon-Puay; Wang, Renwei; Gao, Yu-Tang; Ericson, Ulrika; Sonestedt, Emily; Ziegler, Regina G.; Freedman, Neal D.; Visvanathan, Kala; Jones, Miranda R.; Relton, Caroline; Brennan, Paul; Johansson, Mattias; Ueland, Per Magne (Oxford University Press, 2017-06)
    Background: Circulating concentrations of biomarkers that are related to vitamin status vary by factors such as diet, fortification, and supplement use. Published biomarker concentrations have also been influenced by the ...
    Journal article
  • Identification of shared genetic variants between schizophrenia and lung cancer 

    Zuber, Verena; Jönsson, Erik Gunnar; Frei, Oleksandr; Witoelar, Aree; Thompson, V K; Schork, Andrew J; Bettella, Francesco; Wang, Yunpeng; Djurovic, Srdjan; Smeland, Olav Bjerkehagen; Dieset, Ingrid; Fanous, Ayman H.; Desikan, Rahul S; Küry, Sébastien; Bezieau, Stephane; Dale, Anders M; Mills, Ian Geoffrey; Andreassen, Ole Andreas (Nature Publishing Group, 2018-01-12)
    Epidemiology studies suggest associations between schizophrenia and cancer. However, the underlying genetic mechanisms are not well understood, and difficult to identify from epidemiological data. We investigated if there ...
    Journal article

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