Blar i Department of Clinical Science på tittel

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    • Krill oil attenuates left ventricular dilatation after myocardial infarction in rats 

      Fosshaug, Linn Elisabeth; Berge, Rolf Kristian; Beitnes, Jan Otto; Berge, Kjetil; Vik, Hogne; Aukrust, Pål; Gullestad, Lars; Vinge, Leif Erik; Øie, Erik (Peer reviewed; Journal article, 2011-12-29)
      Background: In the western world, heart failure (HF) is one of the most important causes of cardiovascular mortality. Supplement with n-3 polyunsaturated fatty acids (PUFA) has been shown to improve cardiac function in HF ...

    • Krill oil reduces plasma triacylglycerol level and improves related lipoprotein particle concentration, fatty acid composition and redox status in healthy young adults - a pilot study 

      Berge, Rolf Kristian; Ramsvik, Marie Sannes; Bohov, Pavol; Svardal, Asbjørn; Nordrehaug, Jan Erik; Rostrup, Espen; Bruheim, Inge; Bjørndal, Bodil (Peer reviewed; Journal article, 2015-12-15)
      Background: Lipid abnormalities, enhanced inflammation and oxidative stress seem to represent a vicious circle in atherogenesis, and therapeutic options directed against these processes seems like a reasonable approach in ...

    • Kronisk transplantat-mot-vertsykdom 

      Rørvik, Synne Dragesund; Abrahamsen, Ingerid Weum; Myhre, Anders Eivind; Vo, Camilla Dao; Meling, Eva Ødegaard; Bruserud, Øystein; Gedde-Dahl, Tobias; Tvedt, Tor Henrik Anderson (Journal article; Peer reviewed, 2023)
      Kronisk transplantat-mot-vert-sykdom er en senkomplikasjon etter allogen stamcelletransplantasjon, og medfører kronisk inflammasjon og fibrose i forskjellige organer på grunn av feil regulering av donors immunceller. ...

    • Kvalitet av generika 

      Ashraf, Attyah (Master thesis, 2014-05-20)
      Bakgrunn: Forskning har vist at det er betydelig skepsis i befolkningen til generiske legemidler, selv om disse per definisjon er bioekvivalente. Dette har også blitt vist i flere bioekvivalensstudier. Det rapporteres ...

    • The kynurenine pathway in cognition, dementia, and aging 

      Solvang, Stein-Erik Hafstad (Doctoral thesis, 2021-06-16)
      Background: Experimental studies implicate the kynurenine pathway in cognitive function, dementia, aging, and longevity. Comparatively, clinical studies are few and most lack comprehensive targeted metabolomic profiling ...

    • The Kynurenine Pathway Is Upregulated by Methyl-deficient Diet and Changes Are Averted by Probiotics 

      Tillmann, Sandra; Awwad, Hussain M.; MacPherson, Chad W.; Happ, Denise F.; Treccani, Giulia; Geisel, Juergen; Tompkins, Thomas A.; Ueland, Per Magne; Wegener, Gregers; Obeid, Rima (Journal article; Peer reviewed, 2021)
      Scope Probiotics exert immunomodulatory effects and may influence tryptophan metabolism in the host. Deficiency of nutrients related to C1 metabolism might stimulate inflammation by enhancing the kynurenine pathway. This ...

    • Kynurenine Pathway Metabolites in the Blood and Cerebrospinal Fluid Are Associated with Human Aging 

      Solvang, Stein-Erik Hafstad; Hodge, Allison; Watne, Leiv; Cabral-Marques, Otavio; Nordrehaug, Jan Erik; Giles, Graham G.; Dugué, Pierre-Antoine; Nygård, Ottar Kjell; Ueland, Per Magne; McCann, Adrian; Idland, Ane-Victoria; Midttun, Øivind; Ulvik, Arve; Halaas, Nathalie Bodd; Tell, Grethe S.; Melvær, Giil Lasse (Journal article; Peer reviewed, 2022)
      The kynurenine pathway is implicated in aging, longevity, and immune regulation, but longitudinal studies and assessment of the cerebrospinal fluid (CSF) are lacking. We investigated tryptophan (Trp) and downstream kynurenine ...

    • Kynurenines, Neuropsychiatric Symptoms, and Cognitive Prognosis in Patients with Mild Dementia 

      Solvang, Stein-Erik Hafstad; Nordrehaug, Jan Erik; Aarsland, Dag; Lange, Johannes; Ueland, Per Magne; McCann, Adrian; Midttun, Øivind; Tell, Grethe S.; Melvær, Giil Lasse (Journal article; Peer reviewed, 2019)
      Introduction: Circulating tryptophan (Trp) and its downstream metabolites, the kynurenines, are potentially neuroactive. Consequently, they could be associated with neuropsychiatric symptoms and cognitive prognosis in ...

    • Label-free quantitative proteomic analysis of the oral bacteria Fusobacterium nucleatum and Porphyromonas gingivalis to identify protein features relevant in biofilm formation 

      Mohammed, Marwan; Pettersen, Veronika K.; Nerland, Audun Helge; Wiker, Harald Gotten; Bakken, Vidar (Journal article; Peer reviewed, 2021)
      Background The opportunistic pathogens Fusobacterium nucleatum and Porphyromonas gingivalis are Gram-negative bacteria associated with oral biofilm and periodontal disease. This study investigated interactions between F. ...

    • Laboratory contamination in airway microbiome studies 

      Drengenes, Christine; Wiker, Harald G; Kalananthan, Tharmini; Nordeide, Eli; Eagan, Tomas Mikal; Nielsen, Rune (Peer reviewed; Journal article, 2019-08-14)
      Background The low bacterial load in samples acquired from the lungs, have made studies on the airway microbiome vulnerable to contamination from bacterial DNA introduced during sampling and laboratory processing. We have ...

    • Laparoskopisk gastrisk bypassoperasjon versus livsstilsbehandling av unge med sykelig overvekt 

      Hjelmesæth, Jøran; Hertel, Jens Kristoffer; Holt, Ane Hjetland; Benestad, Beate; Seeberg, Lars Thomas; Lindberg, Morten; Halvorsen, Erling; Juliusson, Petur Benedikt; Sandbu, Rune; Lekhal, Samira (Journal article; Peer reviewed, 2020)
      BAKGRUNN Kunnskapsgrunnlaget om effekten av og komplikasjoner ved vektreduserende kirurgi hos ungdom er mangelfullt. Hovedformålet med 4XL-studien er å avklare om laparoskopisk Roux-en-Y gastrisk bypassoperasjon (LGBP) ...

    • A large community outbreak of waterborne giardiasis- delayed detection in a non-endemic urban area 

      Nygård, Karin; Schimmer, Barbara; Søbstad, Øystein; Walde, Anna; Tveit, Ingvar; Langeland, Nina; Hausken, Trygve; Aavitsland, Preben (BMC Public Health 6(141), Peer reviewed; Journal article, 2006-05-25)
      Background: Giardia is not endemic in Norway, and more than 90% of reported cases acquire the infection abroad. In late October 2004, an increase in laboratory confirmed cases of giardiasis was reported in the city of ...

    • Large-scale genomics unveil polygenic architecture of human cortical surface area 

      Chen, Chi-Hua; Peng, Qian; Schork, Andrew J.; Lo, Min-Tzu; Fan, Chun-Chieh; Wang, Yunpeng; Desikan, Rahul S.; Bettella, Franscesco; Hagler, Donald J.; Westlye, Lars Tjelta; Kremen, William S.; Jernigan, Terry L.; Le Hellard, Stephanie; Steen, Vidar Martin; Espeseth, Thomas; Huentelman, Matt; Håberg, Asta; Agartz, Ingrid; Djurovic, Srdjan; Andreassen, Ole Andreas; Schork, Nicholas; Dale, Anders (Peer reviewed; Journal article, 2015-07-20)
      Little is known about how genetic variation contributes to neuroanatomical variability, and whether particular genomic regions comprising genes or evolutionarily conserved elements are enriched for effects that influence ...

    • Laryngeal response patterns during mechanically assisted cough in Amyotrophic Lateral Sclerosis 

      Andersen, Tiina Maarit (Doctoral thesis, 2018-06-21)
      Background: Patients with amyotrophic lateral sclerosis (ALS) are treated with mechanical cough assist devices using the technique of mechanical insufflationexsufflation (MI-E) in order to improve cough and enhance clearance ...

    • Laryngeal tube use in out-of-hospital cardiac arrest by paramedics in Norway 

      Sunde, Geir Arne; Brattebø, Guttorm; Ødegården, Terje; Kjernlie, Dag Frode; Rødne, Emma Sjøgren; Heltne, Jon-Kenneth (Peer reviewed; Journal article, 2012-12-18)
      Background: Although there are numerous supraglottic airway alternatives to endotracheal intubation, it remains unclear which airway technique is optimal for use in prehospital cardiac arrests. We evaluated the use of the ...

    • Late-onset sepsis in very preterm infants in Norway in 2009-2018: A population-based study 

      Huncikova, Zuzana; Vatne, Anlaug; Stensvold, Hans Jørgen; Lang, Astri Maria; Støen, Ragnhild; Brigtsen, Anne Karin; Salvesen, Bodil; Øymar, Knut Asbjørn Alexander; Rønnestad, Arild Erland; Klingenberg, Claus Andreas (Journal article; Peer reviewed, 2023)
      Objective: To evaluate epidemiology and outcomes among very preterm infants (<32 weeks’ gestation) with culture-positive and culture-negative late-onset sepsis (LOS). Design: Cohort study using a nationwide, population-based ...

    • Late-week surgical treatment of endometrial cancer is associated with worse long-term outcome: Results from a prospective, multicenter study 

      Njølstad, Tormund Salvesen; Werner, Henrica Maria Johanna; Marcickiewicz, Janusz; Tingulstad, Solveig; Staff, Anne Cathrine; Oddenes, Klaus; Bjørge, Line; Engh, Marie Ellström; Woie, Kathrine; Tjugum, Jostein; Lode, Margaret Sævik; Amant, Frédéric; Salvesen, Helga; Trovik, Jone (Peer reviewed; Journal article, 2017-08-03)
      Surgery is the cornerstone in primary endometrial cancer treatment, and with curative intent it constitutes total hysterectomy and bilateral salpingo-oopherectomy. In addition, lymphadenectomy is performed in selected ...

    • Latencies longer than 3.5 ms after vagus nerve stimulation does not exclude a nonrecurrent inferior laryngeal nerve 

      Brauckhoff, Michael; Naterstad, Helle; Brauckhoff, Katrin; Biermann, Martin; Aas, Turid (Peer reviewed; Journal article, 2014-08-28)
      Background: It has recently been reported that a signal latency shorter than 3.5 ms after electrical stimulation of the vagus nerve signify a nonrecurrent course of the inferior laryngeal nerve. We present a patient with ...

    • Latitude, Birth Date, and Allergy 

      Wjst, Matthias; Dharmage, Shyamali; André, Elisabeth; Norbäck, Dan; Raherison, Chantal; Villani, Simona; Manfreda, Jure; Sunyer, Jordi; Jarvis, Deborah; Burney, Peter; Svanes, Cecilie (PLoS Medicine 2(10): e294, Peer reviewed; Journal article, 2005-10-04)
      Background: The space and time distribution of risk factors for allergic diseases may provide insights into disease mechanisms. Allergy is believed to vary by month of birth, but multinational studies taking into account ...

    • Learning from experience: a qualitative study of surgeons’ perspectives on reporting and dealing with serious adverse events 

      Øyri, Sina Furnes; Søreide, Kjetil; Søreide, Eldar; Tjomsland, Ole (Journal article; Peer reviewed, 2023)
      Introduction In surgery, serious adverse events have effects on the patient journey, the patient outcome and may constitute a burden to the surgeon involved. This study aims to investigate facilitators and barriers to ...