Browsing Department of Clinical Science by Title
Now showing items 1359-1378 of 2340
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The lower airways microbiome and antimicrobial peptides in idiopathic pulmonary fibrosis differ from chronic obstructive pulmonary disease
(Journal article; Peer reviewed, 2022)Background The lower airways microbiome and host immune response in chronic pulmonary diseases are incompletely understood. We aimed to investigate possible microbiome characteristics and key antimicrobial peptides and ... -
The lower airways microbiota and antimicrobial peptides indicate dysbiosis in sarcoidosis
(Journal article; Peer reviewed, 2022-10-19)Background: The role of the pulmonary microbiome in sarcoidosis is unknown. The objectives of this study were the following: (1) examine whether the pulmonary fungal and bacterial microbiota differed in patients with ... -
Lower antibiotic prescription rates in hospitalized COVID-19 patients than influenza patients, a prospective study
(Journal article; Peer reviewed, 2022)Background COVID-19 patients are extensively treated with antibiotics despite few bacterial complications. We aimed to study antibiotic use in hospitalized COVID-19 patients compared to influenza patients in two consecutive ... -
Lower circulating neuron-specific enolase concentrations in adults and adolescents with severe mental illness
(Journal article; Peer reviewed, 2021)Background: Both neurodegenerative and neurodevelopmental abnormalities have been suggested to be part of the etiopathology of severe mental illness (SMI). Neuron-specific enolase (NSE), mainly located in the neuronal ... -
LRFN5 locus structure is associated with autism and influenced by the sex of the individual and locus conversions
(Journal article; Peer reviewed, 2022)LRFN5 is a regulator of synaptic development and the only gene in a 5.4 Mb mammalian-specific conserved topologically associating domain (TAD); the LRFN5 locus. An association between locus structural changes and developmental ... -
Lung cancer on Haugalandet, Norway. A long term follow-up study
(Doctoral thesis, 2012-06-06)Background: Little was known on long term survival, the use of hospital days, symptoms both initially and terminally, and the quality of lung cancer care for the population of the patients with lung cancer in Haugalandet, ... -
Lung function and bronchial hyperreactivity from 11 to 18 years in children with bronchiolitis in infancy
(Peer reviewed; Journal article, 2020)Background: Various trajectories for lung function and bronchial hyper‐reactivity (BHR) from early childhood to adulthood are described, including puberty as a period with excessive lung growth. Bronchiolitis in infancy ... -
Lung function at term in extremely preterm-born infants: A regional prospective cohort study
(Journal article; Peer reviewed, 2017)Objectives: To compare lung function of extremely preterm (EP)-born infants with and without bronchopulmonary dysplasia (BPD) with that of healthy term-born infants, and to determine which perinatal characteristics were ... -
Lung hyperinflation and functional exercise capacity in patients with COPD - a three-year longitudinal study
(Peer reviewed; Journal article, 2018-12-06)Background: Lung hyperinflation contributes to dyspnea, morbidity and mortality in chronic obstructive pulmonary disease (COPD). The inspiratory-to-total lung capacity (IC/TLC) ratio is a measure of lung hyperinflation and ... -
Machine learning approaches in microbiome research: challenges and best practices
(Journal article; Peer reviewed, 2023)Microbiome data predictive analysis within a machine learning (ML) workflow presents numerous domain-specific challenges involving preprocessing, feature selection, predictive modeling, performance estimation, model ... -
Machine learning based on biomarker profiles identifies distinct subgroups of heart failure with preserved ejection fraction
(Journal article; Peer reviewed, 2021)Aims The lack of effective therapies for patients with heart failure with preserved ejection fraction (HFpEF) is often ascribed to the heterogeneity of patients with HFpEF. We aimed to identify distinct pathophysiologic ... -
Magnetic Resonance Imaging and Computed Tomography for the Noninvasive Assessment of Arterial Aging: A Review by the VascAgeNet COST Action
(Journal article; Peer reviewed, 2023)Magnetic resonance imaging and computed tomography allow the characterization of arterial state and function with high confidence and thus play a key role in the understanding of arterial aging and its translation into the ... -
Maintained survival outcome after reducing lymphadenectomy rates and optimizing adjuvant treatment in endometrial cancer
(Journal article; Peer reviewed, 2020)Objective: Main controversies in endometrial cancer treatment include the role of lymphadenectomy and optimal adjuvant treatment. We assessed clinical outcome in a population-based endometrial cancer cohort in relation to ... -
Major increase in microbiota-dependent proatherogenic metabolite TMAO one year after bariatric surgery
(Journal article; Peer reviewed, 2016)Background: Trimethylamine-N-oxide (TMAO) is formed in the liver from trimethylamine (TMA), a product exclusively generated by the gut microbiota from dietary phosphatidylcholine and carnitine. An alternative pathway of ... -
Making wise decisions for completion thyroidectomies
(Journal article; Peer reviewed, 2022) -
Malaria prevalence among patients with acute undifferentiated fever in secondary hospitals in India
(Conference poster, 2014-09-22) -
Malaria prevalence and performance of diagnostic tests among patients hospitalized with acute undifferentiated fever in Zanzibar
(Journal article; Peer reviewed, 2022-02-19)Background: Control efforts in Zanzibar reduced the burden of malaria substantially from 2000 to 2015, but re-emergence of falciparum malaria has been observed lately. This study evaluated the prevalence of malaria and ... -
Management and interpretation of heterogeneous observational data: Using insulin-like growth factor-I data from the NordiNet® International Outcome Study
(Peer reviewed; Journal article, 2014-12-09)Objective. The NordiNet® International Outcome Study (IOS), a large-scale, non-interventional, multi-centre, real-world study of Norditropin® treatment, registers insulin-like growth factor-I (IGF-I) values, as measured ... -
Managing Contamination and Diverse Bacterial Loads in 16S rRNA Deep Sequencing of Clinical Samples: Implications of the Law of Small Numbers
(Journal article; Peer reviewed, 2021)In this article, we investigate patterns of microbial DNA contamination in targeted 16S rRNA amplicon sequencing (16S deep sequencing) and demonstrate how this can be used to filter background bacterial DNA in diagnostic ...