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Influence of MDM2 SNP309 and SNP285 status on the risk of cancer in the breast, prostate, lung and colon
MDM2 is a key regulator of the p53 tumor suppressor protein and is overexpressed in many human cancers. Two single nucleotide polymorphisms (SNPs) located in the MDM2 intronic promoter (P2) have been found to exert biological ...
Concomitant inactivation of the p53- and pRB- functional pathways predicts resistance to DNA damaging drugs in breast cancer in vivo
Chemoresistance is the main obstacle to cancer cure. Contrasting studies focusing on single gene mutations, we hypothesize chemoresistance to be due to inactivation of key pathways affecting cellular mechanisms such as ...
Frequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cells
(Cold Spring Harbor Laboratory, 2015)
Mitochondrial genomes are separated from the nuclear genome for most of the cell cycle by the nuclear double membrane, intervening cytoplasm, and the mitochondrial double membrane. Despite these physical barriers, we show ...
MDM4 SNP34091 (rs4245739) and its effect on breast-, colon-, lung- and prostate cancer risk.
The MDM4 protein plays an important part in the negative regulation of the tumor suppressor p53 through its interaction with MDM2. In line with this, MDM4 amplification has been observed in several tumor forms. A polymorphism ...
Performance comparison of three BRAF V600E detection methods in malignant melanoma and colorectal cancer specimen
Personalized cancer care requires reliable biomarkers. While the BRAF V600E mutation is implemented in the clinic, no method for its detection has so far been established as reference. We aimed to perform a comprehensive ...