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High PTEN gene expression is a negative prognostic marker in human primary breast cancers with preserved p53 function
Purpose: PTEN is an important tumor suppressor in breast cancer. Here, we examined the prognostic and predictive value of PTEN and PTEN pseudogene (PTENP1) gene expression in patients with locally advanced breast cancer ...
Activation of Akt characterizes estrogen receptor positive human breast cancers which respond to anthracyclines
(Impact Journals, 2017-04-17)
Anthracyclines are key components of human breast cancer chemotherapy. Here, we explored the role of Akt signaling in anthracycline resistance. The antitumor activity of doxorubicin and Akt inhibitor A-443654 alone or ...
TP53 status predicts long-term survival in locally advanced breast cancer after primary chemotherapy
(Informa Healthcare, 2014-10)
Background: Before the advent of neoadjuvant chemotherapy, radiotherapy and surgery alone were associated with a high risk of uncontrolled locoregional relapses in locally advanced breast cancer (LABC).Material and methods: ...