Now showing items 1-5 of 5
Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1
(Nature Publishing Group, 2015-12-01)
High-risk mutations in several genes predispose to both colorectal cancer (CRC) and endometrial cancer (EC). We therefore hypothesised that some lower-risk genetic variants might also predispose to both CRC and EC. Using ...
DNA ploidy in curettage specimens identifies high-risk patients and lymph node metastasis in endometrial cancer
(Nature Publishing Group, 2015-04-21)
Background: Preoperative risk stratification is essential in tailoring endometrial cancer treatment, and biomarkers predicting lymph node metastasis and aggressive disease are aspired in clinical practice. DNA ploidy ...
ATAD2 overexpression links to enrichment of B-MYBtranslational signatures and development of aggressive endometrial carcinoma
(Impact Journals, 2015)
We have explored the potential for clinical implementation of ATAD2 as a biomarker for aggressive endometrial cancer by investigating to what extent immunohistochemical (IHC) staining for ATAD2 is feasible, reflects clinical ...
HOTAIR and its surrogate DNA methylation signature indicate carboplatin resistance in ovarian cancer
(BioMed Central, 2015-10-24)
Background: Understanding carboplatin resistance in ovarian cancer is critical for the improvement of patients’ lives. Multipotent mesenchymal stem cells or an aggravated epithelial to mesenchymal transition phenotype of ...
Multimodal Imaging of Orthotopic Mouse Model of Endometrial Carcinoma
(Public Library of Science, 2015-08-07)
Background: Orthotopic endometrial cancer models provide a unique tool for studies of tumour growth and metastatic spread. Novel preclinical imaging methods also have the potential to quantify functional tumour ...