Now showing items 1-6 of 6
Identification of shared genetic variants between schizophrenia and lung cancer
(Nature Publishing Group, 2018-01-12)
Epidemiology studies suggest associations between schizophrenia and cancer. However, the underlying genetic mechanisms are not well understood, and difficult to identify from epidemiological data. We investigated if there ...
Genetic variation in 117 myelination-related genes in schizophrenia: Replication of association to lipid biosynthesis genes
(Nature Publishing Group, 2018-05-02)
Schizophrenia is a serious psychotic disorder with high heritability. Several common genetic variants, rare copy number variants and ultra-rare gene-disrupting mutations have been linked to disease susceptibility, but there ...
Recently evolved human-specific methylated regions are enriched in schizophrenia signals
(BioMed Central, 2018)
Background: One explanation for the persistence of schizophrenia despite the reduced fertility of patients is that it is a by-product of recent human evolution. This hypothesis is supported by evidence suggesting that ...
Attenuated Notch signaling in schizophrenia and bipolar disorder
(Nature Research, 2018-03-28)
The Notch signaling pathway plays a crucial role in neurodevelopment and in adult brain homeostasis. We aimed to further investigate Notch pathway activity in bipolar disorder (BD) and schizophrenia (SCZ) by conducting a ...
Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder
(Nature Research, 2018-10-08)
Psychiatric disorders are thought to have a complex genetic pathology consisting of interplay of common and rare variation. Traditionally, pedigrees are used to shed light on the latter only, while here we discuss the ...
Analysis of differentially methylated regions in great apes and extinct hominids provides support for the evolutionary hypothesis of schizophrenia
Introduction: The persistence of schizophrenia in human populations separated by geography and time led to the evolutionary hypothesis that proposes schizophrenia as a by-product of the higher cognitive abilities of ...