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Frequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cells
(Cold Spring Harbor Laboratory, 2015)
Mitochondrial genomes are separated from the nuclear genome for most of the cell cycle by the nuclear double membrane, intervening cytoplasm, and the mitochondrial double membrane. Despite these physical barriers, we show ...
Performance comparison of three BRAF V600E detection methods in malignant melanoma and colorectal cancer specimen
Personalized cancer care requires reliable biomarkers. While the BRAF V600E mutation is implemented in the clinic, no method for its detection has so far been established as reference. We aimed to perform a comprehensive ...