Browsing Department of Clinical Science by Title
Now showing items 417-436 of 2313
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Complications and discomfort of bronchoscopy: a systematic review
(Peer reviewed; Journal article, 2016)Objective: To identify bronchoscopy-related complications and discomfort, meaningful complication rates, and predictors. Method: We conducted a systematic literature search in PubMed on 8 February 2016, using a search ... -
Components of the choline oxidation pathway in relation to acute myocardial infarction, type 2 diabetes and mortality. Prospective observational studies among patients with suspected or verified coronary heart disease in Norway
(Doctoral thesis, 2016-04-07)BACKGROUND. The choline oxidation pathway comprises the sequential metabolism of choline into betaine, dimethylglycine (DMG), and sarcosine. In addition, dietary choline and betaine can be turned into trimethylamine N-amino ... -
The Composite Autonomic Symptom Score 31 Questionnaire: A Sensitive Test to Detect Risk for Autonomic Neuropathy
(Journal article; Peer reviewed, 2023)Background and Aims. Autonomic neuropathy is a common but often neglected complication of diabetes, prediabetes, and even in individuals with an elevated risk of diabetes. The Composite Autonomic Symptom Score (COMPASS) ... -
Composite immune marker scores associated with severe mental disorders and illness course
(Journal article; Peer reviewed, 2022)Background Low-grade inflammation has been implicated in the pathophysiology of severe mental disorders (SMDs) and a link between immune activation and clinical characteristics is suggested. However, few studies have ... -
Comprehensive analysis of epigenetic signatures of human transcription control
(Journal article; Peer reviewed, 2021)Advances in sequencing technologies have enabled exploration of epigenetic and transcriptional profiles at a genome-wide level. The epigenetic and transcriptional landscapes are now available in hundreds of mammalian cell ... -
Comprehensive Analysis of Exported Proteins from Mycobacterium tuberculosis H37Rv
(Proteomics, Peer reviewed; Journal article, 2007-04-21)Proteins secreted by Mycobacterium tuberculosis play an essential role in the pathogenesis of tuberculosis. The culture filtrates of M. tuberculosis H37Rv made by Sadamu Nagai (Japan), are considerably enriched for secreted ... -
Comprehensive assessment of ECM turnover using serum biomarkers establishes PBC as a high-turnover autoimmune liver disease
(Journal article; Peer reviewed, 2021)Background & Aims: Primary sclerosing cholangitis (PSC), primary biliary cholangitis (PBC) and autoimmune hepatitis (AIH) are phenotypically distinct autoimmune liver diseases that progress to cirrhosis and liver failure; ... -
Comprehensive characterization of copy number variation (CNV) called from array, long- and short-read data
(Journal article; Peer reviewed, 2021)Background SNP arrays, short- and long-read genome sequencing are genome-wide high-throughput technologies that may be used to assay copy number variants (CNVs) in a personal genome. Each of these technologies comes with ... -
Computationally efficient familywise error rate control in genome-wide association studies using score tests for generalized linear models
(Journal article; Peer reviewed, 2020)In genetic association studies, detecting phenotype–genotype association is a primary goal. We assume that the relationship between the data—phenotype, genetic markers and environmental covariates—can be modeled by a ... -
Concomitant Hemophagocytic Lymphohistiocytosis and Cytomegalovirus Disease: A Case Based Systemic Review
(Journal article; Peer reviewed, 2022)Background: Hemophagocytic lymphohistiocytosis (HLH) is an immune mediated life-threatening condition. It is driven by an overactivation of the immune system and causes inflammatory tissue damage potentially leading to ... -
Concomitant inactivation of the p53- and pRB- functional pathways predicts resistance to DNA damaging drugs in breast cancer in vivo
(Peer reviewed; Journal article, 2015-10)Chemoresistance is the main obstacle to cancer cure. Contrasting studies focusing on single gene mutations, we hypothesize chemoresistance to be due to inactivation of key pathways affecting cellular mechanisms such as ... -
Consensus recommendations for the treatment and management of patients with Fabry disease on migalastat: a modified Delphi study
(Journal article; Peer reviewed, 2023-09-01)Objective: Fabry disease is a progressive disorder caused by deficiency of the α-galactosidase A enzyme (α-Gal A), leading to multisystemic organ damage with heterogenous clinical presentation. The addition of the oral ... -
Consequences of a high incidence of microsatellite instability and BRAF-mutated tumors: A population-based cohort of metastatic colorectal cancer patients
(Peer reviewed; Journal article, 2019-05-09)Background: Immunotherapy for patients with microsatellite-instable (MSI-H) tumors or BRAF-inhibitors combination treatment for BRAF-mutated (mutBRAF) tumors in metastatic colorectal cancer (mCRC) is promising, but the ... -
Consequences of refining biological networks through detailed pathway information : From genes to proteoforms
(Doctoral thesis, 2022-11-28)Biologiske nettverk kan brukes til å modellere molekylære prosesser, forstå sykdomsprogresjon og finne nye behandlingsstrategier. Denne avhandlingen har undersøkt hvordan utformingen av slike nettverk påvirker deres struktur, ... -
Conservation of Distinct Genetically-Mediated Human Cortical Pattern
(Peer reviewed; Journal article, 2016-07-26)The many subcomponents of the human cortex are known to follow an anatomical pattern and functional relationship that appears to be highly conserved between individuals. This suggests that this pattern and the relationship ... -
Conserved metabolic enzymes as vaccine antigens for giardiasis
(Journal article; Peer reviewed, 2022-04-25)Giardia lamblia is a leading protozoal cause of diarrheal disease worldwide. Infection is associated with abdominal pain, malabsorption and weight loss, and protracted post-infectious syndromes. A human vaccine is not ... -
Consistent biofilm formation by Streptococcus pyogenes emm 1 isolated from patients with necrotizing soft tissue infections
(Journal article; Peer reviewed, 2022-02-18)Objectives: Biofilm formation has been demonstrated in muscle and soft tissue samples from patients with necrotizing soft tissue infection (NSTI) caused by Streptococcus pyogenes, but the clinical importance of this ... -
Constitutional BRCA1 methylation and risk of incident triple-negative breast cancer and high-grade serous ovarian cancer
(Journal article; Peer reviewed, 2022)Importance About 25% of all triple-negative breast cancers (TNBCs) and 10% to 20% of high-grade serous ovarian cancers (HGSOCs) harbor BRCA1 promoter methylation. While constitutional BRCA1 promoter methylation has been ... -
The Constitutive Extracellular Protein Release by Acute Myeloid Leukemia Cells—A Proteomic Study of Patient Heterogeneity and Its Modulation by Mesenchymal Stromal Cells
(Journal article; Peer reviewed, 2021)Extracellular protein release is important both for the formation of extracellular matrix and for communication between cells. We investigated the extracellular protein release by in vitro cultured normal mesenchymal stem ... -
Context dependent regulatory patterns of the androgen receptor and androgen receptor target genes
(Peer reviewed; Journal article, 2016-07-04)Background Expression of the androgen receptor (AR) is associated with androgen-dependent proliferation arrest and terminal differentiation of normal prostate epithelial cells. Additionally, activation of the AR is required ...