Browsing Department of Clinical Science by Issue Date

Now showing items 1-20 of 482

    • Diffusing capacity of the lung for carbon monoxide. Variability and longitudinal changes over nine years 

      Storebø, Michael Langballe (The University of Bergen, 2019-03-13)
      Pulmonary gas exchange oxygenates our blood and facilitates transfer of carbon dioxide produced out of the body. Measurement of pulmonary gas exchange by diffusing capacity of the lung for carbon monoxide (DLCO) shows a ...
      Doctoral thesis

    • Exploring and redefining Autoimmune polyendocrine syndrome type 1 

      Bruserud, Øyvind (The University of Bergen, 2019-02-08)
      Autoimmune polyendocrine syndrome type 1 (APS-1) is a rare, monogenic, childhood-onset disorder caused by mutations in the autoimmune regulator (AIRE) gene. Multi-organ autoimmune disease and chronic mucocutaneous ...
      Doctoral thesis

    • Polarizing versus depolarizing blood cardioplegia: An experimental study of myocardial function, metabolism and ultrastructure following cardiopulmonary bypass and cardioplegic arrest 

      Aass, Terje (The University of Bergen, 2019-01-11)
      In cardiothoracic surgery, the use of the heart-lung machine for cardiopulmonary bypass (CPB) and induced cardiac arrest, cardioplegia, is required for performing the majority of the surgical procedures. Myocardial ...
      Doctoral thesis

    • Preclinical models and molecular biomarkers. Tools to improve treatment in endometrial carcinoma 

      Fonnes, Tina (The University of Bergen, 2018-11-30)
      Background: Endometrial carcinoma is the fourth most common cancer in European women, and incidence is increasing. No major improvements in treatment or survival have been achieved over the last decades, and an individualized ...
      Doctoral thesis

    • High neopterin and IP-10 levels in cerebrospinal fluid are associated with neurotoxic tryptophan metabolites in acute central nervous system infections 

      Quist-Paulsen, Else; Aukrust, Pål; Kran, Anne-Marte Bakken; Dunlop, Oona Borghild; Ormaasen, Vidar; Stiksrud, Birgitte; Midttun, Øivind; Ueland, Thor; Ueland, Per Magne; Mollnes, Tom Eirik; Dyrhol-Riise, Anne Ma (Springer Nature, 2018-11-23)
      Background The host response to intruders in the central nervous system (CNS) may be beneficial but could also be harmful and responsible for neurologic symptoms and sequelae in CNS infections. This immune response induces ...
      Journal article

    • Treatment completion for latent tuberculosis infection in Norway: a prospective cohort study 

      Schein, Yvette Louise; Madebo, Tesfaye; Andersen, Hilde Elise; Arnesen, Trude Margrete; Dyrhol-Riise, Anne Ma; Tveiten, Hallgeir; White, Richard Aubrey; Winje, Brita Askeland (BioMed Central, 2018-11-19)
      Background: Successful treatment of latent tuberculosis infection (LTBI) is essential to reduce tuberculosis (TB) incidence rates in low-burden countries. This study measures treatment completion and determinants of ...
      Journal article

    • Elderly patients’ (≥65 years) experiences associated with discharge; Development, validity and reliability of the Discharge Care Experiences Survey 

      Boge, Ranveig Marie; Haugen, Arvid Steinar; Nilsen, Roy Miodini; Harthug, Stig (Public Library of Science, 2018-11-07)
      Background: A review of the literature reveals a lack of validated instruments that particularly measure quality in the hospital discharge process. This study aims to develop and validate a survey instrument feasible for ...
      Journal article

    • Indwelling urinary catheters, aortic valve treatment and delirium: a prospective cohort study 

      Eide, Leslie Sofia Pareja; Ranhoff, Anette Hylen; Lauck, Sandra; Fridlund, Bengt; Haaverstad, Rune; Hufthammer, Karl Ove; Kuiper, Karel Kier-Jan; Nordrehaug, Jan E; Norekvål, Tone M. (BMJ Publishing Group, 2018-11-01)
      Objectives To determine whether an association exists between delirium and length of time indwelling urine catheters (IUC) are used in octogenarian patients treated with surgical aortic valve treatment (SAVR) or transcatheter ...
      Journal article

    • The association between alcohol consumption and risk of hip fracture differs by age and gender in Cohort of Norway: a NOREPOS study 

      Søgaard, Anne-Johanne; Ranhoff, Anette Hylen; Meyer, Haakon E; Omsland, Tone Kristin; Nystad, Wenche; Tell, Grethe S.; Holvik, Kristin (Springer, 2018-11)
      Summary: The association between alcohol consumption and hip fracture differed by gender: Men aged 30–59 years drinking frequently or 14+ gl/week had higher risk than moderate drinkers. No significant association was ...
      Journal article

    • A novel Geriatric Assessment frailty score predicts two-year mortality after Transcatheter Aortic Valve implantation 

      Skaar, Elisabeth; Eide, Leslie Sofia Pareja; Norekvål, Tone M.; Ranhoff, Anette Hylen; Nordrehaug, Jan Erik; Forman, Daniel E.; Schönenberger, Anders; Hufthammer, Karl Ove; Kuiper, Karel Kier-Jan; Bleie, Øyvind; Haaverstad, Rune; Schaufel, Margrethe Aase; Packer, Erik Jerome Stene; Langørgen, Jørund (Oxford University Press, 2018-10-31)
      Aims Established surgical scores have limitations in delineating risk among candidates for transcatheter aortic valve implantation (TAVI). Assessment of frailty might help to estimate the mortality risk and identify ...
      Journal article

    • Role of rare HNF1A variants function in monogenic and type 2 diabetes 

      Najmi, Laeya Abdoli (The University of Bergen, 2018-10-26)
      Variants in the transcription factor gene HNF1A have been identified in subjects with maturity-onset diabetes of the young (MODY) type 3, type 2 diabetes, as well as in children with apparent type 1 diabetes. One of the ...
      Doctoral thesis

    • Preeclampsia by maternal reasons for immigration: A population-based study 

      Nilsen, Roy Miodini; Vik, Eline Skirnisdottir; Rasmussen, Svein; Small, Rhonda; Moster, Dag; Schytt, Erica; Aasheim, Vigdis (BMC, 2018-10-26)
      Background: To investigate whether the occurrence of preeclampsia varied by maternal reasons for immigration. Methods: We included 1,287,270 singleton pregnancies (163,508 to immigrant women) in Norway during ...
      Journal article

    • Dietary predictors of bone mineral density, hip fractures, mobility and muscle strength - in community-dwelling older persons 

      Rosendahl-Riise, Hanne (The University of Bergen, 2018-10-23)
      Background: The aging process involves decline of both muscle and bone mass. The loss of muscle mass is associated with decreased muscle strength and mobility, while loss of bone mass leads to osteoporosis and increased ...
      Doctoral thesis

    • NR2F1 stratifies dormant disseminated tumor cells in breast cancer patients 

      Borgen, Elin; Rypdal, Maria Christine; Sosa, Maria Soledad; Renolen, Anne; Schlichting, Ellen; Lønning, Per Eystein; Synnestvedt, Marit; Aguirre-Ghiso, Julio; Naume, Bjørn (BMC, 2018-10-16)
      Background: The presence of disseminated tumor cells (DTCs) in bone marrow (BM) is an independent prognostic factor in early breast cancer but does not uniformly predict outcome. Tumor cells can persist in a quiescent ...
      Journal article

    • An evolutionary epigenetics approach to schizophrenia 

      Banerjee, Niladri (The University of Bergen, 2018-09-28)
      Schizophrenia is a psychotic disorder with an estimated lifetime prevalence of ~1% worldwide. Despite reduced fecundity of patients, this rate is stable across population groups separated by geography and time. There is ...
      Doctoral thesis

    • Sarcopenia in patients with hip fracture. A multicenter prospective study with one-year follow-up 

      Steihaug, Ole Martin (The University of Bergen, 2018-09-11)
      Sarcopenia is a geriatric syndrome of reduced muscle mass and physical performance associated with falls, fractures, impairments in activities of daily living, and mortality. Hip fractures are fractures of the upper third ...
      Doctoral thesis

    • The effect of antibiotic stewardship interventions with stakeholder involvement in hospital settings: A multicentre, cluster randomized controlled intervention study 

      Wathne, Jannicke Slettli; Kleppe, Lars Kåre Selland; Harthug, Stig; Blix, Hege Salvesen; Nilsen, Roy Miodini; Charani, Esmita; Smith, Ingrid (BioMed Central, 2018-09-10)
      Background: There is limited evidence from multicenter, randomized controlled studies to inform planning and implementation of antibiotic stewardship interventions in hospitals. Methods: A cluster randomized, controlled, ...
      Journal article

    • Primary aldosteronism in Western Norway. Studies of diagnostic approach and treatment outcome 

      Grytaas, Marianne Aardal (The University of Bergen, 2018-09-06)
      Primary aldosteronism (PA) is the most common cause of secondary hypertension (HT), accounting for 5 to 12% of all hypertensive individuals. Patients with PA experience increased cardiovascular, renal and metabolic ...
      Doctoral thesis

    • The E3 SUMO ligase PIASγ is a novel interaction partner regulating the activity of diabetes associated hepatocyte nuclear factor-1α 

      Kaci, Alba; Keindl, Magdalena; Solheim, Marie Holm; Njølstad, Pål Rasmus; Bjørkhaug, Lise; Aukrust, Ingvild (Springer Nature, 2018-08-24)
      The transcription factor hepatocyte nuclear factor-1α (HNF-1A) is involved in normal pancreas development and function. Rare variants in the HNF1A gene can cause monogenic diabetes, while common variants confer type 2 ...
      Journal article

    • Identification of susceptibility pathways for the roleof chromosome 15q25.1 in modifying lung cancerrisk 

      Ji, Xuemei; Bossé, Yohan; Landi, Maria Teresa; Gui, Jiang; Xiao, Xiangjun; Qian, David C; Joubert, Philippe; Lamontagne, Maxime; Li, Yafang; Gorlov, Ivan; de Biasi, Mariella; Han, Younghun; Gorlova, Olga; Hung, Rayjean J.; Wu, Xifeng; McKay, James; Zong, Xuchen; Carreras-Torres, Robert; Christiani, David C.; Caporaso, Neil; Johansson, Mattias; Liu, Geoffrey; Bojesen, Stig E.; Le Marchand, Loic; Albanes, Demetrios; Bickeboller, Heike; Aldrich, Melinda C.; Bush, William S.; Tardon, Adonina; Rennert, Gad; Chen, Chu; Teare, M. Dawn; Field, John K.; Kiemeney, Lambertus A.; Lazarus, Philip; Haugen, Aage; Lam, Stephen; Schabath, Matthew B.; Andrew, Angeline S.; Shen, Hongbing; Hong, Yun-Chul; Yuan, Jian-Min; Bertazzi, Pier A.; Pesatori, Angela C.; Ye, Yuanqing; Diao, Nancy; Su, Li; Zhang, Ruyang; Brhane, Yonathan; Leighl, Natasha; Johansen, Jakob S.; Mellemgaard, Anders; Saliba, Walid; Haiman, Christopher; Wilkens, Lynne; Fernandez-Somoano, Ana; Fernandez-Tardon, Guillermo; van der Heijden, Erik H. F. M.; Kim, Jin Hee; Dai, Juncheng; Hu, Zhibin; Davies, Michael P.A.; Marcus, Michael W.; Brunnström, Hans; Manjer, Jonas; Melander, Olle; Muller, David C.; Overvad, Kim; Trichopoulou, Antonia; Tumino, Rosario; Doherty, Jennifer; Goodman, Gary; Cox, Angela; Taylor, Fiona; Woll, Penella; Brüske, Irene; Manz, Judith; Muley, Thomas; Risch, Angela; Rosenberger, Albert; Grankvist, Kjell; Johansson, Mikael; Shepherd, Frances; Ming-Sound, Tsao; Arnold, Susanne M.; Haura, Eric B.; Bolca, Ciprian; Holcatova, Ivana; Janout, Vladimir; Kontic, Milica; Lissowska, Jolanta; Mukeria, Anush; Ognjanovic, Simona; Orlowski, Tadeusz M.; Scelo, Ghislaine; Swiatkowska, Beata; Zaridze, David; Bakke, Per S.; Skaug, Vidar; Zienolddiny, Shanbeh; Duell, Eric J.; Butler, Lesley M.; Koh, Woon-Puay; Gao, Yu-Tang; Houlston, Richard; McLaughlin, John; Stevens, Victoria; Nickle, David C.; Obeidat, Ma'en; Timens, Wim; Zhu, Bin; Song, Lei; Artigas, María Soler; Tobin, Martin D.; Wain, Louise V.; Gu, Fangyi; Byun, Jinyoung; Kamal, Ahsan; Zhu, Dakai; Tyndale, Rachel F.; Wei, Wei-Qi; Chanock, Stephen; Brennan, Paul; Amos, Christopher I. (Nature Research, 2018-08-13)
      Genome-wide association studies (GWAS) identified the chromosome 15q25.1 locus as a leading susceptibility region for lung cancer. However, the pathogenic pathways, through which susceptibility SNPs within chromosome 15q25.1 ...
      Journal article