Browsing Department of Clinical Science by Issue Date
Now showing items 1-20 of 461
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Polarizing versus depolarizing blood cardioplegia: An experimental study of myocardial function, metabolism and ultrastructure following cardiopulmonary bypass and cardioplegic arrest
(The University of Bergen, 2019-01-11)In cardiothoracic surgery, the use of the heart-lung machine for cardiopulmonary bypass (CPB) and induced cardiac arrest, cardioplegia, is required for performing the majority of the surgical procedures. Myocardial ...Doctoral thesis -
Preclinical models and molecular biomarkers. Tools to improve treatment in endometrial carcinoma
(The University of Bergen, 2018-11-30)Background: Endometrial carcinoma is the fourth most common cancer in European women, and incidence is increasing. No major improvements in treatment or survival have been achieved over the last decades, and an individualized ...Doctoral thesis -
The association between alcohol consumption and risk of hip fracture differs by age and gender in Cohort of Norway: a NOREPOS study
(Springer, 2018-11)Summary: The association between alcohol consumption and hip fracture differed by gender: Men aged 30–59 years drinking frequently or 14+ gl/week had higher risk than moderate drinkers. No significant association was ...Journal article -
Role of rare HNF1A variants function in monogenic and type 2 diabetes
(The University of Bergen, 2018-10-26)Variants in the transcription factor gene HNF1A have been identified in subjects with maturity-onset diabetes of the young (MODY) type 3, type 2 diabetes, as well as in children with apparent type 1 diabetes. One of the ...Doctoral thesis -
Dietary predictors of bone mineral density, hip fractures, mobility and muscle strength - in community-dwelling older persons
(The University of Bergen, 2018-10-23)Background: The aging process involves decline of both muscle and bone mass. The loss of muscle mass is associated with decreased muscle strength and mobility, while loss of bone mass leads to osteoporosis and increased ...Doctoral thesis -
An evolutionary epigenetics approach to schizophrenia
(The University of Bergen, 2018-09-28)Schizophrenia is a psychotic disorder with an estimated lifetime prevalence of ~1% worldwide. Despite reduced fecundity of patients, this rate is stable across population groups separated by geography and time. There is ...Doctoral thesis -
Sarcopenia in patients with hip fracture. A multicenter prospective study with one-year follow-up
(The University of Bergen, 2018-09-11)Sarcopenia is a geriatric syndrome of reduced muscle mass and physical performance associated with falls, fractures, impairments in activities of daily living, and mortality. Hip fractures are fractures of the upper third ...Doctoral thesis -
Primary aldosteronism in Western Norway. Studies of diagnostic approach and treatment outcome
(The University of Bergen, 2018-09-06)Primary aldosteronism (PA) is the most common cause of secondary hypertension (HT), accounting for 5 to 12% of all hypertensive individuals. Patients with PA experience increased cardiovascular, renal and metabolic ...Doctoral thesis -
Parental involvement in decision-making about their child's health care at the hospital
(Wiley Open Access, 2018-07-30)Aim: To explore parents’ experiences on parental involvement in decision‐making about their child’s health care at the hospital and to identify how health professionals can improve parental involvement. Design: An ...Journal article -
Limited Benefit of Fish Consumption on Risk of Hip Fracture among Men in the Community-Based Hordaland Health Study
(MDPI, 2018-07-06)Hip fractures have a high prevalence worldwide. Few studies have investigated whether fish consumption is associated with risk of hip fractures. The objective of the present study was to investigate the effect of fish ...Journal article -
Intake of baked cod fillet resulted in lower serum cholesterol and higher long chain n-3 PUFA concentrations in serum and tissues in hypercholesterolemic obese Zucker fa/fa rats
(MDPI, 2018-06-28)Increasing evidence indicates that lean fish consumption may benefit cardiovascular health. High cholesterol and low n-3 PUFA concentrations in serum are associated with an increased risk of coronary heart disease; therefore, ...Journal article -
Laryngeal response patterns during mechanically assisted cough in Amyotrophic Lateral Sclerosis
(The University of Bergen, 2018-06-21)Background: Patients with amyotrophic lateral sclerosis (ALS) are treated with mechanical cough assist devices using the technique of mechanical insufflationexsufflation (MI-E) in order to improve cough and enhance ...Doctoral thesis -
The epidemiology and characteristics of sepsis in Norwegian hospitals
(The University of Bergen, 2018-06-08)Background: Sepsis develops when the host’s immune response to infection becomes dysregulated to such an extent that life-threatening organ dysfunction evolves. Sepsis epidemiology is influenced by population characteristics, ...Doctoral thesis -
Recent developments in military transfusion practice and their impact on civilian healthcare
(The University of Bergen, 2018-05-25)Introduction. Massive haemorrhage is the leading cause of preventable death following trauma. The mortality rate is high unless actively managed from Point of Injury (POI). However, during the last decade advances in ...Doctoral thesis -
Peripheral blood stem cell mobilization in healthy Donors by granulocyte colony-stimulating factor causes preferential mobilization of lymphocyte subsets
(Frontiers, 2018-05-02)Background: Allogeneic hematopoietic stem cell transplantation is associated with a high risk of immune-mediated post-transplant complications. Graft depletion of immunocompetent cell subsets is regarded as a possible ...Journal article -
Genetic variation in 117 myelination-related genes in schizophrenia: Replication of association to lipid biosynthesis genes
(Nature Publishing Group, 2018-05-02)Schizophrenia is a serious psychotic disorder with high heritability. Several common genetic variants, rare copy number variants and ultra-rare gene-disrupting mutations have been linked to disease susceptibility, but there ...Journal article -
Impact of HIV and type 2 diabetes on gut microbiota diversity, tryptophan catabolism and endothelial dysfunction
(Springer Nature, 2018-04-30)HIV infection and type 2 diabetes are associated with altered gut microbiota, chronic inflammation, and increased cardiovascular risk. We aimed to investigate the combined effect of these diseases on gut microbiota composition ...Journal article -
The role of PTEN, PI3K-Akt-mTOR signaling and pseudogene PTENP1 in breast cancer
(The University of Bergen, 2018-04-19)Background: Breast cancer is the most common type of cancer in women, and a major cause of premature death still today. The PI3K-Akt-mTOR signaling (in short: PI3K signaling) pathway is a growth and pro-survival pathway, ...Doctoral thesis -
Biofilm and planktonic lifestyles of Porphyromonas gingivalis and Fusobacterium nucleatum. Proteomic analysis of bacteria grown as planktonic cells, mono- and dual species biofilm, and characterization of the biofilm extracellular polymeric matrix’
(The University of Bergen, 2018-04-06)Periodontitis is one of the most prevalent infectious diseases affecting humans. Periodontitis leads to the destruction of the dental support tissues, which in the terminal stage causes loss of teeth. Periodontitis is ...Doctoral thesis -
Paternal and maternal obesity but not gestational weight gain is associated with type 1 diabetes
(Oxford University Press, 2018-04)Background Our objective was to examine the associations of parental body mass index (BMI) and maternal gestational weight gain with childhood-onset type 1 diabetes. Comparing the associations of maternal and paternal BMI ...Journal article
