Blar i Department of Clinical Science på tittel
Viser treff 157-176 av 2396
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Asthma, atopy and lung function in young adults after hospitalisation for bronchiolitis in infancy: impact of virus and sex
(Journal article; Peer reviewed, 2022)Background: Hospitalisation for bronchiolitis is a risk factor for asthma and impaired lung function during childhood, but outcomes in young adults are poorly described. Our primary aim was to study the prevalence of asthma ... -
Asthma, atopy, and lung function in young adults after hospitalization for bronchiolitis in infancy
(Doctoral thesis, 2023-10-06)Bakgrunn: Bronkiolitt er en viral nedre luftveisinfeksjon som ofte rammer spedbarn. Respiratorisk syncytialt virus er det vanligste viruset ved bronkiolitt, etterfulgt av rhinovirus. Bronkiolitt er assosiert med økt risiko ... -
ATAD2 overexpression links to enrichment of B-MYBtranslational signatures and development of aggressive endometrial carcinoma
(Peer reviewed; Journal article, 2015)We have explored the potential for clinical implementation of ATAD2 as a biomarker for aggressive endometrial cancer by investigating to what extent immunohistochemical (IHC) staining for ATAD2 is feasible, reflects clinical ... -
Atherogenic Lipid Ratios Related to Myeloperoxidase and C-Reactive Protein Levels in Psychotic Disorders
(Journal article; Peer reviewed, 2020)Background: Cardiovascular disease (CVD) is a major cause of premature death in patients with psychotic disorders, where dyslipidemia occurs frequently. In the pathogenesis of these serious mental disorders, a low-grade ... -
Atrial Dysfunction in Significant Atrial Functional Mitral Regurgitation: Phenotypes and Prognostic Implications
(Journal article; Peer reviewed, 2023)Background: Atrial functional mitral regurgitation (AFMR) is associated with increased morbidity and mortality. Left atrial (LA) size and function in AFMR are poorly characterized. We aimed to assess LA function by reservoir ... -
Attack rates amongst household members of outpatients with confirmed COVID-19 in Bergen, Norway: A case-ascertained study
(Journal article; Peer reviewed, 2021)Background Households studies reflect the natural spread of SARS-CoV-2 in immunologically naive populations with limited preventive measures to control transmission. We hypothesise that seropositivity provides more ... -
Attempted synthesis of a 2,3,6-trisubstituted 5-pyranone
(Master thesis, 2011-06-14)Carbohydrate analogues are of great interest for the development of new pharmaceutical products. These compounds are attached to the macromolecule via glycosidic linkages, and then influence directly the overall biological ... -
Attempted synthesis of a 3-pyranone from 3,3,4,4-tetraethoxybut-1-yne
(Master thesis, 2010-05-19)The starting material for this project was the highly functionalised compound 3,3,4,4-tetratethoxybut-1-yne (TEB). One of the compounds that can be synthesised from TEB is 1,1-diethoxy-3-(1,3-dithian-2-yl)propan-2-ol ... -
Attention-deficit hyperactivity disorder shares copy number variant risk with schizophrenia and autism spectrum disorder
(Peer reviewed; Journal article, 2019-10-17)Attention-deficit/hyperactivity disorder (ADHD) is a highly heritable common childhood-onset neurodevelopmental disorder. Some rare copy number variations (CNVs) affect multiple neurodevelopmental disorders such as ... -
Attenuated Notch signaling in schizophrenia and bipolar disorder
(Peer reviewed; Journal article, 2018-03-28)The Notch signaling pathway plays a crucial role in neurodevelopment and in adult brain homeostasis. We aimed to further investigate Notch pathway activity in bipolar disorder (BD) and schizophrenia (SCZ) by conducting a ... -
Attitudes among parents of persons with autism spectrum disorder towards information about genetic risk and future health
(Journal article; Peer reviewed, 2021)Clinical relevance of genetic testing is increasing in autism spectrum disorder (ASD). Information about genetic risk may contribute to improved diagnostics, treatment and family planning, but may also be perceived as a ... -
Atypical (non-V600E) BRAF mutations in metastatic colorectal cancer in population and real-world cohorts
(Journal article; Peer reviewed, 2023)BRAF-V600E mutation (mt) is a strong negative prognostic and predictive biomarker in metastatic colorectal cancer (mCRC). Non-V600Emt, designated atypical BRAFmt (aBRAFmt) are rare, and little is known about their frequency, ... -
Augmented CD4+ T-cell and humoral responses after repeated annual influenza vaccination with the same vaccine component A/H1N1pdm09 over 5 years
(Peer reviewed; Journal article, 2018-08-14)Annual seasonal influenza vaccination is recommended for high-risk populations and often occupational groups such as healthcare workers (HCWs). Repeated annual vaccination has been reported to either have no impact or ... -
Autoantibodies against type I IFNs in patients with life-threatening COVID-19
(Journal article; Peer reviewed, 2020)Interindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease ... -
Autoantibody discovery across monogenic, acquired, and COVID-19-associated autoimmunity with scalable PhIP-seq
(Journal article; Peer reviewed, 2022)Phage immunoprecipitation sequencing (PhIP-seq) allows for unbiased, proteome-wide autoantibody discovery across a variety of disease settings, with identification of disease-specific autoantigens providing new insight ... -
Autoantigenic properties of the aminoacyl tRNA synthetase family in idiopathic inflammatory myopathies
(Journal article; Peer reviewed, 2023)Objectives: Autoantibodies are thought to play a key role in the pathogenesis of idiopathic inflammatory myopathies (IIM). However, up to 40% of IIM patients, even those with clinical manifestations of anti-synthetase ... -
Autocrine activation of MAPK signaling mediates intrinsic tolerance to androgen deprivation in LY6D prostate cancer cells
(Journal article; Peer reviewed, 2023)The emergence of castration-resistant prostate cancer remains an area of unmet clinical need. We recently identified a subpopulation of normal prostate progenitor cells, characterized by an intrinsic resistance to androgen ... -
Autoimmune polyendocrine syndrome type I. Novel diagnostic assays and immune regulation
(Doctoral thesis, 2012-02-10)Autoimmune polyendocrine syndrome type I (APS-I) is a rare, monogenetic recessively inherited disease caused by mutations in the autoimmune regulator (AIRE) gene. The patients display different endocrine and ectodermal ... -
Autoimmune primary adrenal insufficiency -current diagnostic approaches and future perspectives
(Journal article; Peer reviewed, 2023)The adrenal glands are small endocrine glands located on top of each kidney, producing hormones regulating important functions in our body like metabolism and stress. There are several underlying causes for adrenal ... -
Autoimmune primary adrenal insufficiency – autoantibodies and cell regeneration
(Doctoral thesis, 2024-02-02)Autoimmun primær binyrebarksvikt er en sjelden lidelse som skyldes autoimmun ødeleggelse av binyrebarken, og foreløpig finnes det ingen kurativ behandling. Her undersøkte vi to distinkte aspekter ved sykdommen, en molekylær ...