• The Bergen 4-Day Treatment for Panic Disorder: A Pilot Study 

      Hansen, Bjarne; Kvale, Gerd; Hagen, Kristen; Hjelle, Kay Morten; Solem, Stian; Bø, Beate Hatlelid; Øst, Lars Gøran (Peer reviewed; Journal article, 2018-06-26)
      The current article reports on the findings from a pilot treatment study on panic disorder (PD) with or without agoraphobia. Consecutively referred patients were included and treated with the Bergen 4-day treatment format. ...
    • Betaine as a determinant of postmethionine load total plasma homocysteine before and after B-Vitamin supplementation 

      Holm, Pål Ivar; Bleie, Øyvind; Ueland, Per Magne; Lien, Ernst Asbjørn; Refsum, Helga; Nordrehaug, Jan Erik; Nygård, Ottar (Peer reviewed; Journal article, 2004)
      Objective—Betaine is a substrate in the betaine– homocysteine methyltransferase reaction, converting homocysteine to methionine. There are only sparse data on plasma betaine as a determinant of the plasma total homocysteine ...
    • Beyond sleep duration: Sleep timing as a risk factor for childhood obesity 

      Skjåkødegård, Hanna Flækøy; Danielsen, Yngvild Sørebø; Frisk, Bente; Hystad, Sigurd William; Roelants, Mathieu; Pallesen, Ståle; Conlon, Rachel; Wilfley, Denise E.; Juliusson, Petur Benedikt (Journal article; Peer reviewed, 2021)
      Background: Ample evidence attests to the relationship between short sleep duration, sleep problems and childhood obesity. However, few studies have examined the association between sleep timing and obesity in children. ...
    • Bi-specific TCR-anti CD3 redirected T-cell targeting of NY-ESO-1- and LAGE-1-positive tumors 

      McCormack, Emmet; Adams, Katherine J.; Hassan, Namir J.; Kotian, Akhil; Lissin, Nikolai M.; Sami, Malkit; Mujic, Maja; Osdal, Tereza; Gjertsen, Bjørn Tore; Baker, Deborah; Powlesland, Alex S.; Aleksic, Milos; Vuidepot, Annelise; Morteau, Olivier; Sutton, Deborah H.; June, Carl H.; Kalos, Michael; Ashfield, Rebecca; Jakobsen, Bent K. (Peer reviewed; Journal article, 2012-12)
      NY-ESO-1 and LAGE-1 are cancer testis antigens with an ideal profile for tumor immunotherapy, combining up-regulation in many cancer types with highly restricted expression in normal tissues and sharing a common HLA-A*0201 ...
    • Bidirectional genetic overlap between autism spectrum disorder and cognitive traits 

      Hope, Sigrun; Shadrin, Alexey; Lin, Aihua; Bahrami, Shahram; Rødevand, Linn; Frei, Oleksandr; Hübenette, Saira Jameela; Cheng, Weiqiu; Hindley, Guy; Nag, Heidi Elisabeth; Ulstein, Line; Efrim-Budisteanu, Magdalena; O’Connell, Kevin; Dale, Anders; Djurovic, Srdjan; Nærland, Terje; Andreassen, Ole (Journal article; Peer reviewed, 2023)
      Autism spectrum disorder (ASD) is a highly heritable condition with a large variation in cognitive function. Here we investigated the shared genetic architecture between cognitive traits (intelligence (INT) and educational ...
    • Bile Acid Profiles in Primary Sclerosing Cholangitis and their Ability to Predict Hepatic Decompensation 

      Mousa, Omar Y; Juran, Brian D; McCauley, Bryan M.; Vesterhus, Mette; Folseraas, Trine; Turgeon, Coleman T.; Ali, Ahmad; Schlicht, Erik M; Atkinson, Elizabeth J; Hu, Chang; Harnois, Denise; Carey, Elizabeth J; Gossard, Andrea A; Oglesbee, Devin; Eaton, John E; LaRusso, Nicholas F.; Gores, Gregory J.; Karlsen, Tom Hemming; Lazaridis, Konstantinos N. (Journal article; Peer reviewed, 2021)
      Background and Aims: Altered bile acid (BA) homeostasis is an intrinsic facet of cholestatic liver diseases, but clinical usefulness of plasma BA assessment in primary sclerosing cholangitis (PSC) remains understudied. We ...
    • Bimodal expression of potential drug target CLL-1 (CLEC12A) on CD34+ blasts of AML patients 

      Ngai, Lok Lam; Ma, Connie Y.; Maguire, Orla; Do, An D.; Robert, Alberto; Logan, Aaron C.; Griffiths, Elizabeth A.; Nemeth, Michael J.; Green, Cherie; Pourmohamad, Tony; van Kuijk, Bo J.; Snel, Alexander N.; Kwidama, Zinia W.; Venniker-Punt, Bianca; Cooper, James; Manz, Markus G.; Gjertsen, Bjørn Tore; Smit, Linda; Ossenkoppele, Gert J.; Janssen, Jeroen J. W. M.; Cloos, Jacqueline; Sumiyoshi, Teiko (Journal article; Peer reviewed, 2021)
      Objectives This study aims to retrospectively assess C-lectin-like molecule 1 (CLL-1) bimodal expression on CD34+ blasts in acute myeloid leukemia (AML) patients (total N = 306) and explore potential CLL-1 bimodal ...
    • Bioactive fatty acids and coronary heart disease. Mechanisms and clinical effects of dietary fatty acids 

      Strand, Elin (Doctoral thesis, 2013-06-26)
      Background: A high intake of omega-3 (n-3) long-chain polyunsaturated fatty acids (LCPUFAs), which are potential peroxisome proliferator-activated receptor (PPAR) agonists, has been associated with proposed favourable ...
    • Bioactive peptides from microalgae: Focus on anti-cancer and immunomodulating activity 

      Skjånes, Kari; Æsøy, Reidun; Herfindal, Lars; Skomedal, Hanne (Journal article; Peer reviewed, 2021)
      In addition to the rapidly expanding field of using microalgae for food and feed, microalgae represent a tremendous potential for new bioactive compounds with health-promoting effects. One field where new therapeutics is ...
    • Biofilm and planktonic lifestyles of Porphyromonas gingivalis and Fusobacterium nucleatum. Proteomic analysis of bacteria grown as planktonic cells, mono- and dual species biofilm, and characterization of the biofilm extracellular polymeric matrix’ 

      Mohammed, Marwan (Doctoral thesis, 2018-04-06)
      Periodontitis is one of the most prevalent infectious diseases affecting humans. Periodontitis leads to the destruction of the dental support tissues, which in the terminal stage causes loss of teeth. Periodontitis is ...
    • Bioinformatic analyses of miRNA-mRNA signature during hiPSC differentiation towards insulin-producing cells upon HNF4α mutation 

      Ghila, Luiza; Bjørlykke, Yngvild; Legøy, Thomas Aga; Vethe, Heidrun; Furuyama, Kenichiro; Chera, Simona; Ræder, Helge (Journal article; Peer reviewed, 2020)
      Mutations in the hepatocyte nuclear factor 4α (HNF4α) gene affect prenatal and postnatal pancreas development, being characterized by insulin-producing β-cell dysfunction. Little is known about the cellular and molecular ...
    • Bioinformatic and Genetic Association Analysis of MicroRNA Target Sites in One-Carbon Metabolism Genes 

      Stone, Nicole; Pangilinan, Faith; Molloy, Anne M.; Shane, Barry; Scott, John M.; Ueland, Per Magne; Mills, James L.; Kirke, Peader N.; Sethupathy, Praveen; Brody, Lawrence C. (Peer reviewed; Journal article, 2011-07-12)
      One-carbon metabolism (OCM) is linked to DNA synthesis and methylation, amino acid metabolism and cell proliferation. OCM dysfunction has been associated with increased risk for various diseases, including cancer and neural ...
    • The Biological Context of C-Reactive Protein as a Prognostic Marker in Renal Cell Carcinoma: Studies on the Acute Phase Cytokine Profile 

      Aarstad, Helene Hersvik; Gudbrandsdottir, Gigja; Hjelle, Karin; Bostad, Leif; Bruserud, Øystein; Tvedt, Tor Henrik Anderson; Beisland, Christian (Journal article; Peer reviewed, 2020)
      High serum levels of the acute phase protein C-reactive protein (CRP) are associated with an adverse prognosis in renal cancer. The acute phase reaction is cytokine-driven and includes a wide range of inflammatory mediators. ...
    • Biological mechanisms for chronic fatigue in primary Sjøgren`s syndrome 

      Norheim, Katrine Brække (Doctoral thesis, 2012-06-15)
      Background: Primary Sjøgren`s syndrome (pSS) is a chronic autoimmune disease, characterised by lymphocytic infiltration of exocrine glands and autoantibody production. Fatigue is a frequent phenomenon in pSS, associated ...
    • Biological variation of cardiac myosin-binding protein C in healthy individuals 

      Alaour, Bashir; Omland, Torbjørn; Torsvik, Janniche; Kaier, Thomas E.; Sylte, Marit S.; Strand, Heidi; Quraishi, Jasmine; McGrath, Sam; Williams, Luke; Meex, Steven; Redwood, Simon; Marber, Michael; Aakre, Kristin M. (Journal article; Peer reviewed, 2021)
      Objectives Cardiac myosin-binding protein C (cMyC) is a novel biomarker of myocardial injury, with a promising role in the triage and risk stratification of patients presenting with acute cardiac disease. In this study, ...
    • Biological variation of secretoneurin; a novel cardiovascular biomarker implicated in arrhythmogenesis 

      Aakre, Kristin Moberg; Ottesen, Anett Hellebø; Strand, Heidi; Faaren, Arne L.; Alaour, Bashir; Torsvik, Janniche; Sylte, Marit Sverresdotter; Marber, Michael; Christensen, Geir; Røsjø, Helge Rørvik; Omland, Torbjørn (Journal article, 2021)
      Background Secretoneurin is a novel prognostic biomarker that may predict mortality in heart failure and the occurrence of ventricular arrhythmias. This study reports the within subject variation (CVI), between subject ...
    • Biomarker changes as surrogate endpoints in early-phase trials in heart failure with reduced ejection fraction 

      Savarese, Gianluigi; Uijl, Alicia; Ouwerkerk, Wouter; Tromp, Jasper; Anker, Stefan D.; Dickstein, Kenneth; Hage, Camilla; Lam, Carolyn S.P.; Lang, Chim C.; Metra, Marco; Ng, Leong L.; Orsini, Nicola; Samani, Nilesh J.; van Veldhuisen, Dirk J.; Cleland, John G.F.; Voors, Adriaan A.; Lund, Lars H. (Journal article; Peer reviewed, 2022)
      Aims No biomarker has achieved widespread acceptance as a surrogate endpoint for early-phase heart failure (HF) trials. We assessed whether changes over time in a panel of plasma biomarkers were associated with subsequent ...
    • Biomarker signature and pathophysiological pathways in patients with chronic heart failure and metabolic syndrome 

      van der Hoef, Camilla C.S.; Boorsma, Eva M.; Emmens, Johanna E.; van Essen, Bart J.; Metra, Marco; Ng, Leong L.; Anker, Stefan D.; Dickstein, Kenneth; Mordi, Ify R.; Dihoum, Adel; Lang, Chim C.; van Veldhuisen, Dirk J.; Lam, Carolyn S.P.; Voors, Adriaan A. (Journal article; Peer reviewed, 2023)
      Aim The comorbidities that collectively define metabolic syndrome are common in patients with heart failure. However, the role of metabolic syndrome in the pathophysiology of heart failure is not well understood. We ...
    • Biomarkers and Algorithms for the Diagnosis of Vitamin B12 Deficiency 

      Hannibal, Luciana; Lysne, Vegard; Bjørke-Monsen, Anne-Lise; Behringer, Sidney; Grünert, Sarah C.; Spiekerkoetter, Ute; Jacobsen, Donald W.; Blom, Henk J. (Peer reviewed; Journal article, 2016-06-27)
      Vitamin B12 (cobalamin, Cbl, B12) is an indispensable water-soluble micronutrient that serves as a coenzyme for cytosolic methionine synthase (MS) and mitochondrial methylmalonyl-CoA mutase (MCM). Deficiency of Cbl, whether ...
    • Biomarkers and echocardiographic predictors of myocardial dysfunction in patients with hypertension 

      Bielecka-Dabrowa, Agata; Michalska-Kasiczak, Marta; Gluba, Anna; Ahmed, Ali; Gerdts, Eva; von Haehling, Stephan; Rysz, Jacek; Banach, Maciej (Peer reviewed; Journal article, 2015-03-09)
      The study aimed to identify early echocardiographic and circulating biomarkers of heart failure (HF) in hypertensive patients with normal resting echocardiography. Echocardiography at rest and during exercise, and selected ...