Now showing items 198-217 of 462

    • Hospitalization for acute myocardial infarction – trends in case fatality, and the impact of changing definition on number of events, subtypes and mortality 

      Langørgen, Jørund (The University of Bergen, 2014-09-24)
      Background: Few studies of acute myocardial infarction (AMI) among hospitalized patients have had direct estimates of long-term case fatality after AMI, and the literature is conflicting regarding gender-related prognosis ...
      Doctoral thesis
    • HOTAIR and its surrogate DNA methylation signature indicate carboplatin resistance in ovarian cancer 

      Teschendorff, Andrew E.; Lee, Shih-Han; Jones, Allison; Fiegl, Heidi; Kalwa, Marie; Wagner, Wolfgang; Chindera, Kantaraja; Evans, Iona; Dubeau, Louis; Orjalo, Arturo; Horlings, Hugo M.; Niederreiter, Lukas; Kaser, Arthur; Yang, Winnie; Goode, Ellen L.; Fridley, Brooke L.; Jenner, Richard G.; Berns, Els M.; Wik, Elisabeth; Salvesen, Helga Birgitte; Wisman, G. B. A.; van der Zee, Ate G.; Davidson, Ben; Trope, Claes Gøran; Lambrechts, Sandrina; Vergote, Ignace; Calvert, Hilary; Jacobs, Ian J.; Widschwendter, Martin (BioMed Central, 2015-10-24)
      Background: Understanding carboplatin resistance in ovarian cancer is critical for the improvement of patients’ lives. Multipotent mesenchymal stem cells or an aggravated epithelial to mesenchymal transition phenotype of ...
      Journal article
    • Human cognitive ability is influenced by genetic variation in components of postsynaptic signalling complexes assembled by NMDA receptors and MAGUK proteins 

      Hill, Wayne David; Davies, Gail; Van De Lagemaat, Louie N.; Christoforou, Andrea; Marioni, Riccardo R.; Duarte Fernandes, Carla; Liewald, David Cherry; Croning, Mike D.R.; Payton, Anthony; Craig, Leone C.A.; Whalley, Lawrence J.; Horan, Michael; Ollier, William E.R.; Hansell, Narelle K.; Wright, Margaret J.; Martin, Nicholas G.; Montgomery, Grant W.; Steen, Vidar Martin; Le Hellard, Stephanie; Espeseth, Thomas; Lundervold, Astri; Reinvang, Ivar; Starr, John M.; Pendleton, Neil; Grant, Seth G.N.; Bates, Timothy C.; Deary, Ian John (Nature Publishing Group, 2014)
      Differences in general cognitive ability (intelligence) account for approximately half of the variation in any large battery of cognitive tests and are predictive of important life events including health. Genome-wide ...
      Journal article
    • Hypomagnesemia and functional hypoparathyroidism due to novel mutations in the Mg-channel TRPM6 

      Astor, Marianne; Løvås, Kristian; Wolff, Anette Susanne Bøe; Nedrebø, Bjørn Gunnar; Bratland, Eirik; Steen-Johnsen, Jon; Husebye, Eystein Sverre (Bioscientifica, 2015)
      Primary hypomagnesemia with secondary hypocalcemia (HSH) is an autosomal recessive disorder characterized by neuromuscular symptoms in infancy due to extremely low levels of serum magnesium and moderate to severe hypocalcemia. ...
      Journal article
    • Hypoxia and hypotension in patients intubated by physician staffed helicopter emergency medical services - a prospective observational multi-centre study 

      Sunde, Geir Arne; Sandberg, Mårten; Lyon, Richard; Fredriksen, Knut; Burns, Brian; Hufthammer, Karl Ove; Røislien, Jo; Sóti, Ákos; Jäntti, Helena; Lockey, David; Heltne, Jon-Kenneth; Sollid, Stephen J. M. (BioMed Central, 2017-07-11)
      Background: The effective treatment of airway compromise in trauma and non-trauma patients is important. Hypoxia and hypotension are predictors of negative patient outcomes and increased mortality, and may be important ...
      Journal article
    • Identification and molecular characterization of a new ovarian cancer susceptibility locus at 17q21.31 

      Permuth-Wey, Jennifer; Lawrenson, K; Shen, HC; Velkova, A; Tyrer, JP; Chen, ZH; Lin, HY; Chen, YA; Tsai, YY; Qu, XT; Ramus, SJ; Karevan, R; Lee, J; Lee, N; Larson, MC; Aben, KK; Anton-Culver, H; Antonenkova, N; Antoniou, AC; Armasu, SM; Bacot, F; Baglietto, L; Bandera, EV; Barnholtz-Sloan, J; Beckmann, MW; Birrer, MJ; Bloom, G; Bogdanova, N; Brinton, LA; Brooks-Wilson, A; Brown, R; Butzow, R; Cai, QY; Campbell, I; Chang-Claude, J; Chanock, S; Chenevix-Trench, G; Cheng, JQ; Cicek, MS; Coetzee, GA; Cook, LS; Couch, FJ; Cramer, DW; Cunningham, JM; Dansonka-Mieszkowska, A; Despierre, E; Doherty, JA; Dork, T; du Bois, A; Durst, M; Easton, DF; Eccles, D; Edwards, R; Ekici, AB; Fasching, PA; Fenstermacher, DA; Flanagan, JM; Garcia-Closas, M; Gentry-Maharaj, A; Giles, GG; Glasspool, RM; Gonzalez-Bosquet, J; Goodman, MT; Gore, M; Gorski, B; Gronwald, J; Hall, P; Halle, Mari Kyllesø; Harter, P; Heitz, F; Hillemanns, P; Hoatlin, M; Hogdall, CK; Hogdall, E; Hosono, S; Jakubowska, A; Jensen, A; Jim, H; Kalli, KR; Karlan, BY; Kaye, SB; Kelemen, LE; Kiemeney, LA; Kikkawa, F; Konecny, GE; Krakstad, Camilla; Kjaer, SK; Kupryjanczyk, J; Lambrechts, D; Lambrechts, S; Lancaster, JM; Le, ND; Leminen, A; Levine, DA; Liang, D; Lim, BK; Lin, J; Lissowska, J; Lu, KH; Lubinski, J; Lurie, G; Massuger, LFAG; Matsuo, K; McGuire, V; McLaughlin, JR; Menon, U; Modugno, F; Moysich, KB; Nakanishi, T; Narod, SA; Nedergaard, L; Ness, RB; Nevanlinna, H; Nickels, S; Noushmehr, H; Odunsi, K; Olson, SH; Orlow, I; Paul, J; Pearce, CL; Pejovic, T; Pelttari, LM; Pike, MC; Poole, EM; Raska, P; Renner, SP; Risch, HA; Rodriguez-Rodriguez, L; Rossing, MA; Rudolph, A; Runnebaum, IB; Rzepecka, IK; Salvesen, Helga Birgitte; Schwaab, I; Severi, G; Shridhar, V; Shu, XO; Shvetsov, YB; Sieh, W; Song, HL; Southey, MC; Spiewankiewicz, B; Stram, D; Sutphen, R; Teo, SH; Terry, KL; Tessier, DC; Thompson, PJ; Tworoger, SS; van Altena, AM; Vergote, I; Vierkant, RA; Vincent, D; Vitonis, AF; Wang-Gohrke, S; Weber, RP; Wentzensen, N; Whittemore, AS; Wik, Elisabeth; Wilkens, LR; Winterhoff, B; Woo, YL; Wu, AH; Xiang, YB; Yang, HP; Zheng, W; Ziogas, A; Zulkifli, F; Phelan, CM; Iversen, E; Schildkraut, JM; Berchuck, A; Fridley, BL; Goode, EL; Pharoah, PDP; Monteiro, ANA; Sellers, TA; Gayther, SA (Nature Publishing Group, 2013-03-27)
      Epithelial ovarian cancer (EOC) has a heritable component that remains to be fully characterized. Most identified common susceptibility variants lie in non-protein-coding sequences. We hypothesized that variants in the 3′ ...
      Journal article
    • Identification of diarrheagenic Escherichia coli isolated from infants and children in Dar es Salaam, Tanzania 

      Moyo, Sabrina John; Maselle, Samwel Y.; Matee, Mecky I.; Langeland, Nina; Mylvaganam, Haima (BioMed Central, 2007-08-09)
      Background: Relatively few studies have been done in Tanzania to detect and classify diarrheagenic Escherichia coli (DEC) strains among children with diarrhea. This study aimed at investigating DEC among children in Dar ...
      Journal article
    • Identification of genetic loci shared between schizophrenia and the Big Five personality traits 

      Smeland, Olav Bjerkehagen; Wang, Yunpeng; Lo, Min-Tzu; Li, Wen; Frei, Oleksandr; Witoelar, Aree; Tesli, Martin Steen; Hinds, David A.; Tung, Joyce Y.; Djurovic, Srdjan; Chen, Chi-Hua; Dale, Anders; Andreassen, Ole Andreas (Nature Publishing Group, 2017-05-22)
      Schizophrenia is associated with differences in personality traits, and recent studies suggest that personality traits and schizophrenia share a genetic basis. Here we aimed to identify specific genetic loci shared between ...
      Journal article
    • Identification of novel monocistronic HTLV-1 mRNAs encoding functional Rex isoforms 

      Rende, Francesca; Cavallari, Ilaria; Andresen, Vibeke; Valeri, Valerio W.; D'Agostino, Donna M.; Franchini, Genoveffa; Ciminale, Vincenzo (BioMed Central, 2015-07-02)
      Background: Human T cell leukemia virus type 1 (HTLV-1) gene expression is controlled by the key regulatory proteins Tax and Rex. The concerted action of these proteins results in a two-phase kinetics of viral expression ...
      Journal article
    • Identification of shared genetic variants between schizophrenia and lung cancer 

      Zuber, Verena; Jönsson, Erik Gunnar; Frei, Oleksandr; Witoelar, Aree; Thompson, V K; Schork, Andrew J; Bettella, Francesco; Wang, Yunpeng; Djurovic, Srdjan; Smeland, Olav Bjerkehagen; Dieset, Ingrid; Fanous, Ayman H.; Desikan, Rahul S; Küry, Sébastien; Bezieau, Stephane; Dale, Anders M; Mills, Ian Geoffrey; Andreassen, Ole Andreas (Nature Publishing Group, 2018-01-12)
      Epidemiology studies suggest associations between schizophrenia and cancer. However, the underlying genetic mechanisms are not well understood, and difficult to identify from epidemiological data. We investigated if there ...
      Journal article
    • Immune activation and HIV-specific T cell responses are modulated by a cyclooxygenase-2 inhibitor in untreated HIV-infected individuals: An exploratory clinical trial 

      Prebensen, Christian; Trøseid, Marius; Ueland, Thor; Dahm, Anders Erik A; Sandset, Per Morten; Aaberge, Ingeborg Sundsvalen; Waalen, Kristian; Dyrhol-Riise, Anne Ma; Tasken, Kjetil; Kvale, Dag (PLOS, 2017-05-02)
      Pathologically elevated immune activation and inflammation contribute to HIV disease progression and immunodeficiency, potentially mediated by elevated levels of prostaglandin E2, which suppress HIV-specific T cell responses. ...
      Journal article
    • Immune cells and soluble immune markers in different stages of tuberculosis. Potential biomarkers for diagnosis and treatment efficacy 

      Wergeland, Ida (The University of Bergen, 2017-03-30)
      Tuberculosis (TB) is a major global health problem, especially in the developing world. In order to end the TB epidemic, reliable and rapid diagnostic tools that can identify and discriminate between latent and active TB ...
      Doctoral thesis
    • Immune Responses in Acute and Convalescent Patients with Mild, Moderate and Severe Disease during the 2009 Influenza Pandemic in Norway 

      Mohn, Kristin Greve Isdahl; Cox, Rebecca Jane; Tunheim, Gro; Berdal, Jan Erik; Hauge, Anna G; Jul-Larsen, Åsne; Peters, Bjørn; Oftung, Fredrik; Jonassen, Christine M; Mjaaland, Siri (Plos, 2015-11-25)
      Increased understanding of immune responses influencing clinical severity during pandemic influenza infection is important for improved treatment and vaccine development. In this study we recruited 46 adult patients during ...
      Journal article
    • Immunomodulation induced by stem cell mobilization and harvesting in healthy donors: Increased systemic osteopontin levels after treatment with granulocyte colony-stimulating factor 

      Melve, Guro Kristin; Ersvær, Elisabeth; Akkøk, Cigdem Ahaein; Ahmed, Aymen B; Kristoffersen, Einar Klæboe; Hervig, Tor; Bruserud, Øystein (MDPI, 2016-07-19)
      Peripheral blood stem cells from healthy donors mobilized by granulocyte colony-stimulating factor (G-CSF) and harvested by leukapheresis are commonly used for allogeneic stem cell transplantation. The frequency of severe ...
      Journal article
    • Impact of a surgical safety checklist on safety culture, morbidity, and mortality. A stepped-wedge cluster randomised controlled trial 

      Haugen, Arvid Steinar (The University of Bergen, 2014-08-26)
      Introduction: The incidence of in-hospital adverse events is estimated to occur in approximately 1 out of 10 patients. Events happening during surgical procedures contribute up to 60%, and of these, more than half are ...
      Doctoral thesis
    • Impact of HIV and type 2 diabetes on gut microbiota diversity, tryptophan catabolism and endothelial dysfunction 

      Hoel, Hedda Benedicte; Hove-Skovsgaard, Malene; Hov, Johannes Espolin Roksund; Gaardbo, Julie Christine; Holm, Kristian; Kummen, Martin; Rudi, Knut; Nwosu, Felix; Valeur, Jørgen; Gelpi, Marco; Seljeflot, Ingebjørg; Ueland, Per Magne; Gerstoft, Jan; Ullum, Henrik; Aukrust, Pål; Nielsen, Susanne Dam; Trøseid, Marius (Springer Nature, 2018-04-30)
      HIV infection and type 2 diabetes are associated with altered gut microbiota, chronic inflammation, and increased cardiovascular risk. We aimed to investigate the combined effect of these diseases on gut microbiota composition ...
      Journal article
    • Impact of KRAS, BRAF, PIK3CA, TP53 status and intraindividual mutation heterogeneity on outcome after liver resection for colorectal cancer metastases 

      Løes, Inger Marie; Immervoll, Heike; Sorbye, Halfdan; Angelsen, Jon-Helge; Horn, Arild; Knappskog, Stian; Lønning, Per Eystein (Wiley, 2016-04)
      We determined prognostic impact of KRAS, BRAF, PIK3CA and TP53 mutation status and mutation heterogeneity among 164 colorectal cancer (CRC) patients undergoing liver resections for metastatic disease. Mutation status was ...
      Journal article
    • Impact of Pre-Pregnancy BMI on B Vitamin and Inflammatory Status in Early Pregnancy: An Observational Cohort Study 

      Monsen, Anne Lise Bjørke; Ulvik, Arve; Nilsen, Roy Miodini; Midttun, Øivind; Roth, Christine; Magnus, Per; Stoltenberg, Camilla; Vollset, Stein Emil; Reichborn-Kjennerud, Ted; Ueland, Per Magne (MDPI, 2016-11-30)
      Maternal nutrition and inflammation have been suggested as mediators in the development of various adverse pregnancy outcomes associated with maternal obesity. We have investigated the relation between pre-pregnancy BMI, ...
      Journal article
    • Impact of the World Health Organization’s Surgical Safety Checklist on safety culture in the operating theatre: a controlled intervention study 

      Haugen, Arvid Steinar; Søfteland, Eirik; Eide, Geir Egil; Sevdalis, Nick; Vincent, Charles A.; Nortvedt, Monica Wammen; Harthug, Stig (Oxford University Press on behalf of the British Journal of Anaesthesia, 2013-05)
      Background: Positive changes in safety culture have been hypothesized to be one of the mechanisms behind the reduction in mortality and morbidity after the introduction of the World Health Organization’s Surgical Safety ...
      Journal article
    • Impaired lymphatic function accelerates cancer growth 

      Steinskog, Eli Sihn Samdal; Sagstad, Solfrid Johanne; Wagner, Marek; Karlsen, Tine Veronica; Yang, Ning; Markhus, Carl Erik Nordvik; Yndestad, Synnøve; Wiig, Helge; Eikesdal, Hans Petter (Impact Journals, 2016-06-13)
      Increased lymphangiogenesis is a common feature of cancer development and progression, yet the influence of impaired lymphangiogenesis on tumor growth is elusive. C3HBA breast cancer and KHT-1 sarcoma cell lines were ...
      Journal article