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    • Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders 

      Andlauer, Till F.M.; Guzman-Parra, José; Streit, Fabian; Strohmaier, Jana; González, Maria José; Flores, Susana Gil; Fabeiro, Francisco J. Cabaleiro; Noriega, Francisco del Río; Perez, Fermin Perez; González, Jesus Haro; Diaz, Guillermo Orozco; Diego-Otero, Yolanda de; Moreno-Küstner, Berta; Auburger, Georg; Degenhardt, Franziska; Heilmann-Heimbach, Stefanie; Herms, Stefan; Hoffmann, Per; Frank, Josef; Foo, Jerome C.; Treutlein, Jens; Witt, Stephanie H.; Cichon, Sven; Kogevinas, Manolis; Bøen, Erlend; Dale, Anders M.; Djurovic, Srdjan; Elvsåshagen, Torbjørn; Reinbold, Céline Sonja; Smeland, Olav Bjerkehagen; Agartz, Ingrid; Melle, Ingrid; Ødegaard, Ketil Joachim; Stordal, Eystein; Andreassen, Ole; Rivas, Fabio; Mayoral, Fermín; Müller-Myhsok, Bertram; Forstner, Andreas J.; Nöthen, Markus M.; Rietschel, Marcella; Stahl, Eli A.; Breen, Gerome; McQuillin, Andrew; Ripke, Stephan; Trubetskoy, Vassily; Mattheisen, Manuel; Wang, Yunpeng; Morken, Gunnar; Vaaler, Arne (Journal article; Peer reviewed, 2021)
      Multiplex families with a high prevalence of a psychiatric disorder are often examined to identify rare genetic variants with large effect sizes. In the present study, we analysed whether the risk for bipolar disorder (BD) ...

    • Bivariate causal mixture model quantifies polygenic overlap between complex traits beyond genetic correlation 

      Frei, Oleksandr; Holland, Dominic; Smeland, Olav Bjerkehagen; Shadrin, Alexey A.; Fan, Chun Chieh; Maeland, Steffen; O'Connell, Kevin S.; Wang, Yunpeng; Djurovic, Srdjan; Thompson, Wesley Kurt; Andreassen, Ole Andreas; Dale, Anders (Peer reviewed; Journal article, 2019-06-03)
      Accumulating evidence from genome wide association studies (GWAS) suggests an abundance of shared genetic influences among complex human traits and disorders, such as mental disorders. Here we introduce a statistical tool, ...

    • A Blended Learning Course Design in Clinical Pharmacology for Post-graduate Dental Students 

      Rosenbaum, Paul-Erik Lillholm; Mikalsen, Øyvind; Lygre, Henning; Solheim, Einar; Schjøtt, Jan (Peer reviewed; Journal article, 2012)
      Postgraduate courses in clinical pharmacology are important for dentists to be updated on drug therapy and information related to their clinical practice, as well as knowledge of relevant adverse effects and interactions. ...

    • Blood eosinophils during bronchiolitis: Associations with atopy, asthma and lung function in young adults 

      Sørensen, Karen Galta; Øymar, Knut Asbjørn Alexander; Dalen, Ingvild; Halvorsen, Thomas; Mikalsen, Ingvild Bruun (Journal article; Peer reviewed, 2023)
      Aim: To study if blood eosinophils during bronchiolitis were associated with atopy, asthma and lung function in young adults and if these associations differed between respiratory syncytial virus (RSV) bronchiolitis and ...

    • Blood Lactate AUC Is a Sensitive Test for Evaluating the Effect of Exercise Training on Functional Work Capacity in Patients with Chronic Heart Failure 

      Valborgland, Torstein; Isaksen, Kjetil; Munk, Peter Scott; Larsen, Alf Inge (Journal article; Peer reviewed, 2021)
      Purpose. Exercise training is an essential treatment option for patients with chronic heart failure (CHF). However, it remains controversial, which surrogate measures of functional work capacity are most reliable. The ...

    • Blood Metabolites Associate with Prognosis in Endometrial Cancer 

      Strand, Elin; Tangen, Ingvild Løberg; Fasmer, Kristine Eldevik; Jacob, Havjin; Halle, Mari Kyllesø; Hoivik, Erling A; Delvoux, Bert; Trovik, Jone; Haldorsen, Ingfrid S.; Romano, Andrea; Krakstad, Camilla (Peer reviewed; Journal article, 2019-12-14)
      Endometrial cancer has a high prevalence among post-menopausal women in developed countries. We aimed to explore whether certain metabolic patterns could be related to the characteristics of aggressive disease and poorer ...

    • Blood neurofilament light concentration at admittance: a potential prognostic marker in COVID‑19 

      Aamodt, Anne Hege; Høgestøl, Einar August; Popperud, Trine Haug; Holter, Jan Cato; Dyrhol-Riise, Anne Ma; Tonby, Kristian; Stiksrud, Birgitte; Berge, Tone; Barratt-Due, Andreas; Aukrust, Pål; Heggelund, Lars; Blennow, Kaj; Zetterberg, Henrik; Harbo, Hanne Flinstad; Quist‑Paulsen, Else (Journal article; Peer reviewed, 2021)
      Objective To test the hypotheses that blood biomarkers for nervous system injury, serum concentrations of neurofilament light chain protein (NfL) and glial fibrillary acidic protein (GFAp) can serve as biomarkers for ...

    • Blood steroid levels predict survival in endometrial cancer and reflect tumor estrogen signaling 

      Forsse, David Erik; Tangen, Ingvild Løberg; Fasmer, Kristine Eldevik; Halle, Mari Kyllesø; Viste, Kristin; Almås, Bjørg; Bertelsen, Bjørn-Erik; Trovik, Jone; Haldorsen, Ingfrid S.; Krakstad, Camilla (Peer reviewed; Journal article, 2020-02)
      Objective Blood-based biomarkers are attractive due to ease of sampling and standardized measurement technology, reducing obstacles to clinical implementation. The objective of this study was to evaluate a clinically ...

    • Bloodlettings in Hemochromatosis Result in Increased Blood Lead (Pb) Concentrations 

      Yazdani, Mazyar; Distante, Sonia; Mørkrid, Lars; Ulvik, Rune Johan; Bolann, Bjørn Johan (Journal article; Peer reviewed, 2022)
      Hemochromatosis is a hereditary disorder, most often associated with mutations of the HFE (High FErrum) gene. If left untreated, it can result in severe parenchymal iron accumulation. Bloodletting is the mainstay treatment. ...

    • BLR1 and FCGR1A transcripts in peripheral blood associate with the extent of intrathoracic tuberculosis in children and predict treatment outcome 

      Jenum, Synne; Bakken, Rasmus; Sivakumaran, Dhanasekaran; Mukherjee, Aparna; Lodha, Rakesh; Singh, Sarman; Singh, Varinder; Haks, Marielle C.; Ottenhoff, Tom H.M.; Kabra, Sushil K.; Doherty, Timothy Mark; Ritz, Christian; Grewal, Harleen (Peer reviewed; Journal article, 2016-12-12)
      Biomarkers reflecting the extent of Mycobacterium tuberculosis-induced pathology and normalization during anti-tuberculosis treatment (ATT) would considerably facilitate trials of new treatment regimens and the identification ...

    • BMI and BMI SDS in childhood: annual increments and conditional change 

      Brannsether-Ellingsen, Bente; Eide, Geir Egil; Roelants, Mathieu; Bjerknes, Robert; Juliusson, Petur Benedikt (Peer reviewed; Journal article, 2016)
      Background: Early detection of abnormal weight gain in childhood may be important for preventive purposes. It is still debated which annual changes in BMI should warrant attention. Aim: To analyse 1-year increments of Body ...

    • Body mass index and childhood symptoms of depression, anxiety, and attention-deficit hyperactivity disorder: A within-family Mendelian randomization study 

      Hughes, Amanda M.; Sanderson, Eleanor; Morris, Tim; Ayorech, Ziada; Tesli, Martin Steen; Ask, Helga; Reichborn-Kjennerud, Ted; Andreassen, Ole; Magnus, Per Minor; Helgeland, Øyvind; Johansson, Stefan; Njølstad, Pål Rasmus; Davey Smith, George; Havdahl, Alexandra Karoline Saasen; Howe, Laura D.; Davies, Neil Martin (Journal article; Peer reviewed, 2022)
      Background: Higher BMI in childhood is associated with emotional and behavioural problems, but these associations may not be causal. Results of previous genetic studies imply causal effects but may reflect influence of ...

    • Bone mineral density and vitamin D in paediatric intestinal failure patients receiving home parenteral nutrition 

      Kvammen, Janne Anita; Thomassen, Rut Anne; Kjeserud, Christina; Sæland, Camilla; Godang, Kristin; Bollerslev, Jens; Thorsby, Per Medbøe; Juliusson, Petur Benedikt; Bentsen, Beint Sigmund; Henriksen, Christine (Journal article; Peer reviewed, 2020)
      Background & aims Patients with intestinal failure (IF) are dependent on long-term home parenteral nutrition (HPN) to ensure growth and development. The primary aim of the present study was to assess bone mineral density ...

    • Bones, blood and steel: How bioelectrical impedance analysis is affected by hip fracture and surgical implants 

      Steihaug, Ole Martin; Bogen, Bård Erik; Kristoffersen, Målfrid Holen; Ranhoff, Anette Hylen (Peer reviewed; Journal article, 2017)
      Introduction: Bioelectrical impedance analysis (BIA) is in widespread use, but there is uncertainty about its validity in patients with metal implants or after acute hip fracture and surgery. We aimed to investigate the ...

    • Boosting of cross-reactive and protection-associated T cells in children after live attenuated influenza vaccination 

      Mohn, Kristin Greve-Isdahl; Zhou, Fan; Brokstad, Karl Albert; Sridhar, Saranya; Cox, Rebecca Jane (Peer reviewed; Journal article, 2017-05)
      Background. Live attenuated influenza vaccines (LAIVs) stimulate a multifaceted immune response including cellular immunity, which may provide protection against newly emerging strains. This study shows proof of concept ...

    • Boosting Schizophrenia Genetics by Utilizing Genetic Overlap With Brain Morphology 

      van der Meer, Dennis; Shadrin, Alexey; O'Connell, Kevin Sean; Bettella, Francesco; Djurovic, Srdjan; Wolfers, Thomas; Alnæs, Dag; Agartz, Ingrid; Smeland, Olav Bjerkehagen; Melle, Ingrid; Sánchez, Jennifer Monereo; Linden, David E.J.; Dale, Anders; Westlye, Lars Tjelta; Andreassen, Ole; Frei, Oleksandr; Kaufmann, Tobias (Journal article; Peer reviewed, 2022)
      Background Schizophrenia is a complex polygenic disorder with subtle, distributed abnormalities in brain morphology. There are indications of shared genetic architecture between schizophrenia and brain measures despite ...

    • Borderline values of troponin-T and high sensitivityC-reactive protein did not predict 2-year mortality inTnTpositive chest-pain patients, whereas brain natriureticpeptide did 

      Nilsen, Dennis W.T.; Mjelva, Øistein; Leon de la Fuente, Ricardo; Næsgaard, Patrycja; Pønitz, Volker; Andersen, Trygve Brugger; Grundt, Heidi; Staines, Harry; Nilsen, Stein Tore (Peer reviewed; Journal article, 2015-04-08)
      Background: Troponin-T (TnT), high-sensitive C-reactive protein (hsCRP), and Brain Natriuretic Peptide (BNP) have been shown to be independent prognostic indicators of total and cardiac death during short- and long-term ...

    • Bounding the average causal effect in Mendelian randomisation studies with multiple proposed instruments: An application to prenatal alcohol exposure and attention deficit hyperactivity disorder 

      Diemer, Elizabeth W.; Havdahl, Alexandra; Andreassen, Ole A.; Munafò, Marcus R.; Njølstad, Pål Rasmus; Tiemeier, Henning; Zuccolo, Luisa; Swanson, Sonja A. (Journal article; Peer reviewed, 2023)
      Background As large-scale observational data become more available, caution regarding causal assumptions remains critically important. This may be especially true for Mendelian randomisation (MR), an increasingly popular ...

    • The brain and brown fat 

      Contreras, Cristina; Gonzalez, Francisco; Fernø, Johan; Diéguez, Carlos; Rahmouni, Kamal; Nogueiras, Rubén; López, Miguel (Peer reviewed; Journal article, 2015-06-10)
      Brown adipose tissue (BAT) is a specialized organ responsible for thermogenesis, a process required for maintaining body temperature. BAT is regulated by the sympathetic nervous system (SNS), which activates lipolysis and ...

    • ‘Brain fog’, guilt, and gratitude: experiences of symptoms and life changes in older survivors 6 months after hospitalisation for COVID-19 

      Heiberg, Kristi Elisabeth; Heggestad, Anne Kari Tolo; Jøranson, Nina; Lausund, Hilde; Breievne, Grete; Myrstad, Marius; Ranhoff, Anette Hylen; Walle-Hansen, Marte; Bruun-Olsen, Vigdis (Journal article; Peer reviewed, 2022)
      Purpose Several of those who have been infected with COVID-19 suffer from the post-COVID-19 condition months after the acute infection. Little is known about how older survivors have experienced the consequences and how ...