Blar i Department of Clinical Science på tittel

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    • Changes in pulmonary function and feasibility of portable continuous laryngoscopy during maximal uphill running 

      Engan, Mette; Jansrud, Ida; Stensrud, Trine; Gundersen, Hilde; Edvardsen, Elisabeth; Clemm, Hege Havstad (Journal article; Peer reviewed, 2020)
      Objective To evaluate changes in pulmonary function and feasibility of portable continuous laryngoscopy during maximal uphill running. Methods Healthy volunteers participated in an uphill race. Forced expiratory volume ...

    • Changes in the symptom pattern and the densities of large-intestinal endocrine cells following Campylobacter infection in irritable bowel syndrome: a case report 

      El-Salhy, Magdy; Mazzawi, Tarek; Gundersen, Doris; Hatlebakk, Jan Gunnar; Hausken, Trygve (Peer reviewed; Journal article, 2013-09-29)
      Background Irritable bowel syndrome (IBS) is a common chronic functional gastrointestinal disorder. Post-infectious IBS (PI-IBS) is a subset of IBS that accounts for a large proportion of IBS patients. The PI-IBS symptoms ...

    • The chaperonin CCT8 controls proteostasis essential for T cell maturation, selection, and function 

      Oftedal, Bergithe Eikeland; Maio, Stefano; Handel E, Adam; White PJ, Madeleine; Howie, Duncan; Davis, Simon; Prevot, Nicolas; Rota A, Ioanna; Deadman E, Mary; Kessler M, Benedict; Fischer, Roman; Trede S, Nikolaus; Sezgin, Erdinc; Maizels M, Rick; Holländer, Georg A. (Journal article; Peer reviewed, 2021)
      T cells rely for their development and function on the correct folding and turnover of proteins generated in response to a broad range of molecular cues. In the absence of the eukaryotic type II chaperonin complex, CCT, T ...

    • Characterisation of age and polarity at onset in bipolar disorder 

      Kalman, Janos L.; Loohuis, Loes M. Olde; Vreeker, Annabel; McQuillin, Andrew; Stahl, Eli A.; Ruderfer, Douglas; Grigoroiu-Serbanescu, Maria; Panagiotaropoulou, Georgia; Ripke, Stephan; Bigdeli, Tim B.; Stein, Frederike; Meller, Tina; Meinert, Susanne; Pelin, Helena; Streit, Fabian; Papiol, Sergi; Adams, Mark J.; Adolfsson, Rolf; Adorjan, Kristina; Agartz, Ingrid; Aminoff, Sofie Ragnhild; Anderson-Schmidt, Heike; Andreassen, Ole Andreas; Ardau, Raffaella; Aubry, Jean-Michel; Balaban, Ceylan; Djurovic, Srdjan; Lagerberg, Trine Vik; Melle, Ingrid; Smeland, Olav Bjerkehagen; O'Connell, Kevin Sean (Journal article; Peer reviewed, 2021)
      Background Studying phenotypic and genetic characteristics of age at onset (AAO) and polarity at onset (PAO) in bipolar disorder can provide new insights into disease pathology and facilitate the development of screening ...

    • Characterisation of HNF1A variants in paediatric diabetes in Norway using functional and clinical investigations to unmask phenotype and monogenic diabetes 

      Svalastoga, Pernille; Kaci, Alba; Molnes, Janne; Solheim, Marie Holm; Johansson, Bente Berg; Krogvold, Lars; Skrivarhaug, Torild; Valen, Eivind; Johansson, Stefan; Molven, Anders; Sagen, Jørn Vegard; Søfteland, Eirik; Bjørkhaug, Lise; Tjora, Erling; Aukrust, Ingvild; Njølstad, Pål Rasmus (Journal article; Peer reviewed, 2023)
      Aims/hypothesis Correctly diagnosing MODY is important, as individuals with this diagnosis can discontinue insulin injections; however, many people are misdiagnosed. We aimed to develop a robust approach for determining ...

    • Characterisation of Leishmania amino acid permease 3 (AAP3) coding sequences and flanking regions as a target of detection and diagnosis of the leishmaniases 

      Müller, Karl Erik (Doctoral thesis, 2020-05-29)
      The protozoan parasites of Leishmania genus are the etiological agents of the leishmaniases, diseases whose clinical manifestations range from being asymptomatic, self-healing cutaneous lesions, via mutilating muco-cutaneous ...

    • Characterising the shared genetic determinants of bipolar disorder, schizophrenia and risk-taking 

      Hindley, Guy Frederick Lanyon; Bahrami, Shahram; Steen, Nils Eiel; O'Connell, Kevin Sean; Frei, Oleksandr; Shadrin, Alexey; Bettella, Francesco; Rødevand, Linn; Fan, Chun-Chieh; Dale, Anders; Djurovic, Srdjan; Smeland, Olav Bjerkehagen; Andreassen, Ole (Journal article; Peer reviewed, 2021)
      Increased risk-taking is a central component of bipolar disorder (BIP) and is implicated in schizophrenia (SCZ). Risky behaviours, including smoking and alcohol use, are overrepresented in both disorders and associated ...

    • Characteristics of first-time fathers of advanced age: a Norwegian population-based study 

      Nilsen, Anne Britt Vika; Waldenström, Ulla; Rasmussen, Svein; Hjelmstedt, Anna; Schytt, Erica (Peer reviewed; Journal article, 2013-01-30)
      Background: The modern phenomenon of delayed parenthood applies not only to women but also to men, but less is known about what characterises men who are expecting their first child at an advanced age. This study investigates ...

    • Characterization of abscesses from liver, pancreas and kidney using deep sequencing of the 16S rRNA gene 

      Bivand, Joanna Malgorzata; Nygaard, Randi Monsen; Kommedal, Øyvind (Journal article; Peer reviewed, 2021)
      To characterize the microbial communities in abscess material from liver, pancreas, and kidneys, we performed deep sequencing of the 16S rRNA gene, in addition to cultivation and Sanger based 16S rRNA gene sequencing ...

    • Characterization of adipose tissue and liver innate immune cells in obesity-related insulin resistance 

      Strand, Kristina (Doctoral thesis, 2020-12-04)
      Obesity is a highly prevalent disease associated with a number of chronic and noncommunicable diseases including type 2 diabetes (T2D), nonalcoholic fatty liver disease (NAFLD), and cardiovascular disease (CVD). Obesity ...

    • Characterization of arachnoid cysts using clinical chemistry, qualitative and quantitative proteomics 

      Berle, Magnus (Doctoral thesis, 2013-05-03)
      Arachnoid cyst are benign intracranial lesions with a reported prevalence up to 1.1 % in the population. The origin of such cysts and the mechanisms of filling and sustaining are poorly understood. The aim of the thesis ...

    • Characterization of extracellular polymeric matrix, and treatment of Fusobacterium nucleatum and Porphyromonas gingivalis biofilms with DNase I and proteinase K 

      Mohammed, Marwan; Nerland, Audun Helge; Al-Haroni, Mohammed; Bakken, Vidar (Peer reviewed; Journal article, 2013-01-29)
      Background : Biofilms are organized communities of microorganisms embedded in a self-produced extracellular polymeric matrix (EPM), often with great phylogenetic variety. Bacteria in the subgingival biofilm are key factors ...

    • Characterization of Glycosylation-Specific Systemic and Mucosal IgA Antibody Responses to Escherichia coli Mucinase YghJ (SslE) 

      Riaz, Saman; Steinsland, Hans; Thorsing, Mette; Andersen, Ann Z.; Boysen, Anders T.; Hanevik, Kurt (Journal article; Peer reviewed, 2021)
      Efforts to develop broadly protective vaccines against pathogenic Escherichia coli are ongoing. A potential antigen candidate for vaccine development is the metalloprotease YghJ, or SslE. YghJ is a conserved mucinase that ...

    • Characterization of Patients in the International Severe Asthma Registry with High Steroid Exposure Who Did or Did Not Initiate Biologic Therapy 

      Chen, Wenjia; Sadatsafavi, Mohsen; Tran, Trung N.; Murray, Ruth B.; Wong, Chong Boon Nigel; Ali, Nasloon; Ariti, Cono; Gil, Esther Garcia; Newell, Anthony; Alacqua, Marianna; Al-Ahmad, Mona; Altraja, Alan; Al-Lehebi, Riyad; Bhutani, Mohit; Bjermer, Leif; Bjerrum, Anne Sofie; Bourdin, Arnaud; Bulathsinhala, Lakmini; von Bülow, Anna; Busby, John; Canonica, Giorgio Walter; Carter, Victoria; Christoff, George C.; Cosio, Borja G.; Costello, Richard W.; Fitzgerald, J. Mark; Fonseca, João A.; Ha Yoo, Kwang; Heaney, Liam G.; Heffler, Enrico; Hew, Mark; Hilberg, Ole; Hoyte, Flavia; Iwanaga, Takashi; Jackson, David J.; Jones, Rupert C.; Koh, Mariko Siyue; Kuna, Piotr; Larenas-Linnemann, Désirée; Lehmann, Sverre; Lehtimäki, Lauri A.; Lyu, Juntao; Mahboub, Bassam; Maspero, Jorge; Menzies-Gow, Andrew N.; Sirena, Concetta; Papadopoulos, Nikolaos; Papaioannou, Andriana I.; De Llano, Luis Pérez; Perng, Diahn-Warng; Peters, Matthew; Pfeffer, Paul E.; Porsbjerg, Celeste M.; Popov, Todor A.; Rhee, Chin Kook; Salvi, Sundeep; Taillé, Camille; Taube, Christian; Torres-Duque, Carlos A.; Ulrik, Charlotte S.; Won Ra, Seung; Wang, Eileen; Wechsler, Michael E.; Price, David B. (Journal article; Peer reviewed, 2022)
      Background: Many severe asthma patients with high oral corticosteroid exposure (HOCS) often do not initiate biologics despite being eligible. This study aimed to compare the characteristics of severe asthma patients with ...

    • Characterization of the genetic architecture of infant and early childhood body mass index 

      Helgeland, Øyvind; Vaudel, Marc; Sole-Navais, Pol; Flatley, Christopher; Juodakis, Julius; Bacelis, Jonas; Koløen, Ingvild; Knudsen, Gun Peggy Strømstad; Johansson, Bente Berg; Magnus, Per Minor; Reichborn-Kjennerud, Ted; Juliusson, Pétur Benedikt; Stoltenberg, Camilla; Holmen, Oddgeir Lingaas; Andreassen, Ole; Jacobsson, Bo; Njølstad, Pål Rasmus; Johansson, Stefan (Journal article; Peer reviewed, 2022)
      Early childhood obesity is a growing global concern; however, the role of common genetic variation on infant and child weight development is unclear. Here, we identify 46 loci associated with early childhood body mass index ...

    • Characterizing the Genetic Overlap Between Psychiatric Disorders and Sleep-Related Phenotypes 

      O'Connell, Kevin Sean; Frei, Oleksandr; Bahrami, Shahram; Smeland, Olav Bjerkehagen; Bettella, Francesco; Cheng, Weiqiu; Chu, Yunhan; Hindley, Guy; Lin, Aihua; Shadrin, Alexey; Barrett, Elizabeth Ann; Lagerberg, Trine Vik; Steen, Nils Eiel; Dale, Anders M.; Djurovic, Srdjan; Andreassen, Ole A. (Journal article; Peer reviewed, 2021)
      Background: A range of sleep disturbances are commonly experienced by patients with psychiatric disorders, and genome-wide genetic analyses have shown some significant genetic correlations between these traits. Here, we ...

    • CHEK2 Mutations Affecting Kinase Activity Together With Mutations in TP53 Indicate a Functional Pathway Associated with Resistance to Epirubicin in Primary Breast Cancer 

      Chrisanthar, Ranjan; Knappskog, Stian; Løkkevik, Erik; Anker, Gun Birgitta; Østenstad, Bjørn; Lundgren, Steinar; Berge, Elisabet Ognedal; Risberg, Terje; Mjaaland, Ingvil; Mæhle, Lovise; Engebretsen, Lars Fredrik; Lillehaug, Johan; Lønning, Per Eystein (Peer reviewed; Journal article, 2008-08-26)
      Background: Chemoresistance is the main obstacle to cure in most malignant diseases. Anthracyclines are among the main drugs used for breast cancer therapy and in many other malignant conditions. Single parameter analysis ...

    • Chemical diversity and cellular effects of antifungal cyclic lipopeptides from cyanobacteria 

      Fewer, David P.; Jokela, Jouni; Heinilä, Lassi; Aesoy, Reidun; Sivonen, Kaarina; Galica, Tomáš; Hrouzek, Pavel; Herfindal, Lars (Journal article; Peer reviewed, 2021)
      Cyanobacteria produce a variety of chemically diverse cyclic lipopeptides with potent antifungal activities. These cyclic lipopeptides have an amphipathic structure comprised of a polar peptide cycle and hydrophobic fatty ...

    • A chicken protein hydrolysate exerts anti-atherosclerotic effect beyond plasma cholesterol-lowering activity in Apoe−/− mice 

      Bjørndal, Bodil; Aloysius, Thomas Aquinas; Lund, Anders; Slizyte, Rasa; Bohov, Pavol; Carvajal, Ana Karina; Berge, Rolf Kristian (Peer reviewed; Journal article, 2019-01-13)
      Chicken protein hydrolysates (CPHs) generated from rest raw materials through enzymatic hydrolysis using Corolase PP or Alcalase were shown to reduce inflammation and stimulate hepatic mitochondrial fatty acid oxidation ...

    • Children born preterm at the turn of the millennium had better lung function than children born similarly preterm in the early 1990s. 

      Vollsæter, Maria; Skromme, Kaia; Satrell, Emma; Clemm, Hege; Røksund, Ola; Øymar, Knut; Markestad, Trond; Halvorsen, Thomas (Peer reviewed; Journal article, 2015-12-07)
      Objective. Compare respiratory health in children born extremely preterm (EP) or with extremely low birthweight (ELBW) nearly one decade apart, hypothesizing that better perinatal management has led to better outcome. ...