• Clinical and molecular effects of guanylate cyclase C-activation 

      Tronstad, Rune Rose (Doctoral thesis, 2019-06-06)
      We studied a large Norwegian family who had been affected by chronic diarrhoea and other symptoms from the digestive tract throughout several generations. Our genetic studies showed that family members with diarrhoea shared ...
    • Clinical and molecular implications of NAB2-STAT6 fusion variants in solitary fibrous tumour 

      Georgiesh, Tatiana; Namløs, Heidi Maria; Sharma, Nitin; Lorenz, Susanne; Myklebost, Ola; Bjerkehagen, Bodil; Meza-Zepeda, Leonardo A.; Boye, Kjetil (Journal article; Peer reviewed, 2021)
      Solitary fibrous tumour (SFT) is a mesenchymal neoplasm characterised by pathognomonic NAB2-STAT6 gene fusions. The clinical implications and prognostic value of different fusion variants has not been clarified. In the ...
    • Clinical and molecular markers in endometrial cancer. Studying prognostic and predictive biomarkers that can help to individualise therapeutic decisions 

      Werner, Henrica Maria Johanna (Doctoral thesis, 2014-05-20)
      Background: Endometrial carcinoma is one of the most common cancer types in women, and incidence is increasing globally. Although many cancers are detected at an early stage and will be treated adequately with surgery ...
    • Clinical Characteristics and Histopathology in Suspected Necrotizing Soft Tissue Infections 

      Gundersen, Ingunn Margareetta; Berget, Ellen; Haugland, Hans Kristian; Bruun, Trond; Almeland, Stian Kreken; Assmus, Jörg; Rath, Eivind; Norrby-Teglund, Anna; Skrede, Steinar; Mosevoll, Knut Anders (Journal article; Peer reviewed, 2022)
      Background Necrotizing soft tissue infections (NSTIs) are severe diseases with high morbidity and mortality. The diagnosis is challenging. Several guidelines recommend tissue biopsies as an adjunct diagnostic in routine ...
    • Clinical characteristics, risk factors and outcomes in patients with severe COVID-19 registered in the ISARIC WHO clinical characterisation protocol: a prospective, multinational, multicentre, observational study 

      Reyes, Luis Felipe; Murthy, Srinivas; Garcia-Gallo, Esteban; Irvine, Mike; Merson, Laura; Martin-Loeches, Ignacio; Rello, Jordi; Taccone, Fabio S.; Fowler, Robert A.; Docherty, Annemarie B.; Kartsonaki, Christiana; Aragao, Irene; Barrett, Peter W.; Beane, Abigail; Burrell, Aidan J.C.; Cheng, Matthew Pellan; Christian, Michael D.; Cidade, Jose Pedro; Citarella, Barbara Wanjiru; Donnelly, Christl A.; Fernandes, Susana M.; French, Craig; Haniffa, Rashan; Harrison, Ewen M.; Ho, Antonia Ying Wai; Joseph, Mark; Khan, Irfan Ahmad; Kho, Michelle E.; Kildal, Anders Benjamin; Kutsogiannis, Demetrios; Lamontagne, François; Bekken, Gry Klouman; Dudman, Susanne Gjeruldsen; Dyrhol-Riise, Anne Ma; Heggelund, Lars; Hesstvedt, Liv; Holten, Aleksander Rygh; Holter, Jan Cato; Jenum, Synne; Johal, Simreen Kaur; Lind, Andreas; Müller, Fredrik; Muller, Karl Erik; Pettersen, Frank O.; Quist-Paulsen, Else; Reikvam, Dag Henrik; Skeie, Linda Gail; Skogen, Vegard; Stiksrud, Birgitte; Tonby, Kristian (Journal article; Peer reviewed, 2022)
      Due to the large number of patients with severe coronavirus disease 2019 (COVID-19), many were treated outside the traditional walls of the intensive care unit (ICU), and in many cases, by personnel who were not trained ...
    • Clinical features and risk factors for death in acute undifferentiated fever: A prospective observational study in rural community hospitals in six states of India 

      Mørch, Kristine; Manoharan, Anand; Chandy, Sara; Singh, Ashita; Kuriakose, Cijoy; Patil, Suvarna; Henry, Anil; Chacko, Novin; Alvarez-Uria, Gerardo; Nesaraj, Joel; Blomberg, Bjørn; Kurian, Siby; Haanshuus, Christel Gill; Antony, George; Langeland, Nina; Mathai, Dilip (Journal article; Peer reviewed, 2023)
      Background Acute undifferentiated fever (AUF) ranges from self-limiting illness to life-threatening infections, such as sepsis, malaria, dengue, leptospirosis and rickettsioses. Similar clinical presentation challenges ...
    • Clinical impact of changes in mitral regurgitation severity after medical therapy optimization in heart failure 

      Pagnesi, Matteo; Adamo, Marianna; Sama, Iziah E.; Anker, Stefan D.; Cleland, John G.; Dickstein, Kenneth; Filippatos, Gerasimos S.; Inciardi, Riccardo M.; Lang, Chim C.; Lombardi, Carlo; Ng, Leong L.; Ponikowski, Piotr; Samani, Nilesh J.; Zannad, Faiez; van Veldhuisen, Dirk J.; Voors, Adriaan A.; Metra, Marco (Journal article; Peer reviewed, 2022)
      Background: Few data are available regarding changes in mitral regurgitation (MR) severity with guideline-recommended medical therapy (GRMT) in heart failure (HF). Our aim was to evaluate the evolution and impact of MR ...
    • Clinical implications of left atrial changes after optimization of medical therapy in patients with heart failure 

      Inciardi, Riccardo M.; Pagnesi, Matteo; Lombardi, Carlo M.; Anker, Stefan D.; Cleland, John G.; Dickstein, Kenneth; Filippatos, Gerasimos S.; Lang, Chim C.; Ng, Leong L.; Pellicori, Pierpaolo; Ponikowski, Piotr; Samani, Nilesh J.; Zannad, Faiez; van Veldhuisen, Dirk J.; Solomon, Scott D.; Voors, Adriaan A.; Metra, Marco (Journal article; Peer reviewed, 2022)
      Aims Limited data exist regarding the prognostic relevance of changes in left atrial (LA) dimensions in patients with heart failure (HF). We assessed changes in LA dimension and their relation with outcomes after optimization ...
    • Clinical implications of low estimated protein intake in patients with heart failure 

      Streng, Koen W.; Hillege, Hans L.; ter Maaten, Jozine M.; van Veldhuisen, Dirk J.; Dickstein, Kenneth; Ng, Leong L.; Samani, Nilesh J.; Metra, Marco; Ponikowski, Piotr; Cleland, John G.; Anker, Stefan D.; Romaine, Simon P.R.; Damman, Kevin; van der Meer, Peter; Lang, Chim C.; Voors, Adriaan A. (Journal article; Peer reviewed, 2022)
      Background: A higher protein intake has been associated with a higher muscle mass and lower mortality rates in the general population, but data about protein intake and survival in patients with heart failure (HF) are ...
    • Clinical outcomes among young patients with Fabry disease who initiated agalsidase beta treatment before 30 years of age: An analysis from the Fabry registry 

      Hopkin, Robert J.; Cabrera, Gustavo; Jefferies, John; Yang, Meng; Ponce, Elvira; Brand, Eva; Feldt-Rasmussen, Ulla; Germain, Dominique P.; Guffon, Nathalie; Jovanovic, Ana; Kantola, Ilkka; Karaa, Amel; Martins, Ana; Tøndel, Camilla; Wilcox, William R; Yoo, Han-Wook; Burlina, Alessandro; Mauer, Michael (Journal article; Peer reviewed, 2023)
      Background Clinical manifestations of classic Fabry disease (α-galactosidase A deficiency) usually occur in childhood, while complications involving major organs typically develop in adulthood. Outcomes of Fabry-specific ...
    • Clinical parameters affecting survival outcomes in patients with low-grade serous ovarian carcinoma: An international multicentre analysis 

      May, Taymaa; Bernardini, Marcus; Lheureux, Stephanie; Aben, Katja K.H.; Bandera, Elisa V.; Beckmann, Matthias W.; Benitez, Javier; Berchuck, Andrew; Bjørge, Line; Carney, Michael E.; Cramer, Daniel W.; Defazio, Anna; Dörk, Thilo; Eccles, Diana M.; Friedlander, Michael; García, María Jose; Goode, Ellen L.; Hein, Alexander; Jensen, Allan; Johnatty, Sharon; Kennedy, Catherine J.; Kiemeney, Lambertus A.; Kjær, Susanne K.; Kupryjanczyk, Jolanta; Matsuo, Keitaro; McGuire, Valerie; Modugno, Francesmary; Paddock, Lisa E.; Pejovic, Tanja; Phelan, Catherine M.; Riggan, Marjorie J.; Rodriguez-Antona, Cristina; Rothstein, Joseph H.; Sieh, Weiva; Song, Honglin; Terry, Kathryn L.; Altena, Anne M. Van; Vanderstichele, Adriaan; Vergote, Ignace; Thomsen, Liv Cecilie Vestrheim; Webb, Penelope M.; Wentzensen, Nicolas; Wilkens, Lynne R.; Ziogas, Argyrios; Jiang, Haiyan; Tone, Alicia (Journal article; Peer reviewed, 2023)
      Background: Women with low-grade ovarian serous carcinoma (LGSC) benefit from surgical treatment; however, the role of chemotherapy is controversial. We examined an international database through the Ovarian Cancer Association ...
    • The clinical relevance of animal models in Sjögren's syndrome: The interferon signature from mouse to man 

      Maria, Naomi I.; Vogelsang, Petra; Versnel, Marjan A. (Peer reviewed; Journal article, 2015-07-03)
      Mouse models have been widely used to elucidate the pathogenic mechanisms of human diseases. The advantages of using these models include the ability to study different stages of the disease with particular respect to ...
    • Clinical relevance of globotriaosylceramide accumulation in Fabry disease and the effect of agalsidase beta in affected tissues 

      Tøndel, Camilla; Thurberg, Beth L.; DasMahapatra, Pronabesh; Lyn, Nicole; Maski, Manish; Batista, Julie L.; George, Kelly; Patel, Hiren; Hariri, Ali (Journal article; Peer reviewed, 2022)
      Fabry disease (FD) is a rare lysosomal storage disorder, characterized by a reduction in α-galactosidase A enzyme activity and the progressive accumulation of globotriaosylceramide (GL3) and its metabolites in the cells ...
    • The clinical significance of exercise-induced cardiac biomarkers 

      Kleiven, Øyunn (Doctoral thesis, 2020-01-17)
      Background Physical exercise induces changes in cardiac biomarkers associated with cardiac injury and inflammation. The ability of these changes to identify subjects at risk of sport-related cardiac events is largely ...
    • Clinical studies of epidemic influenza and pandemic COVID-19 to improve the chain of patient care: from bedside diagnostics to long-term complications : 

      Fjelltveit, Elisabeth Berg (Doctoral thesis, 2022-11-29)
      Tidlig diagnostikk og rask og målrettet behandling kan forbedre utfallet av influensa og Covid-19 sykdom. Gjennom prospektive, kontrollerte observasjonsstudier har vi vist betydningen av rask diagnostikk for å redusere ...
    • The clinical use of mechanical insufflation-exsufflation in children with neuromuscular disorders in Europe 

      Hov, Brit; Andersen, Tiina Maarit; Hovland, Vegard; Toussaint, Michel (Journal article; Peer reviewed, 2018)
      Mechanical insufflation-exsufflation (MI-E) is a strategy to treat pulmonary exacerbations in neuromuscular disorders (NMDs). Pediatric guidelines for optimal setting titration of MI-E are lacking and the settings used in ...
    • Clinicopathological factors associated with tumour-specific mutation detection in plasma of patients with RAS-mutated or BRAF-mutated metastatic colorectal cancer 

      Hamfjord, Julian; Guren, Tormod Kyrre; Glimelius, Bengt; Sorbye, Halfdan; Pfeiffer, Per; Dajani, Olav; Lingjærde, Ole Christian; Tveit, Magne Kjell; Pallisgaard, Niels; Spindler, Karen-Lise Garm; Kure, Elin Wenche Hegland (Journal article; Peer reviewed, 2021)
      Detection of tumour-specific circulating cell-free DNA in plasma (ctDNA) fails in a significant number of cases depending on the clinical context. The primary aim was to investigate clinicopathological factors associated ...
    • Clonal evolution after treatment pressure in multiple myeloma: heterogenous genomic aberrations and transcriptomic convergence 

      Misund, Kristine; Hofste op Bruinink, Davine; Coward, Eivind; Hoogenboezem, Remco M.; Rustad, Even Holth; Sanders, Mathijs A.; Rye, Morten Beck; Sponaas, Anne-Marit; van der Holt, Bronno; Zweegman, Sonja; Hovig, Eivind; Meza, Leonardo Zepeda; Sundan, Anders; Myklebost, Ola; Sonneveld, Pieter; Waage, Anders (Journal article; Peer reviewed, 2022)
      We investigated genomic and transcriptomic changes in paired tumor samples of 29 in-house multiple myeloma (MM) patients and 28 patients from the MMRF CoMMpass study before and after treatment. A change in clonal composition ...
    • Clonal evolution in primary breast cancers under sequential epirubicin and docetaxel monotherapy 

      Venizelos, Andreas; Engebrethsen, Christina; Deng, Wei; Geisler, Jürgen; Geisler, Stephanie; Iversen, Gjertrud Titlestad; Aas, Turid; Aase, Hildegunn Siv; Seyedzadeh, Manouchehr; Steinskog, Eli Sihn Samdal; Myklebost, Ola; Nakken, Sigve; Vodák, Daniel; Hovig, Eivind; Meza, Leonardo Zepeda; Lønning, Per Eystein; Knappskog, Stian; Eikesdal, Hans Petter (Journal article; Peer reviewed, 2022)
      Background Subclonal evolution during primary breast cancer treatment is largely unexplored. We aimed to assess the dynamic changes in subclonal composition of treatment-naïve breast cancers during neoadjuvant ...
    • Clonal heterogeneity reflected by pi3k-akt-mtor signaling in human acute myeloid leukemia cells and its association with adverse prognosis 

      Nepstad, Ina; Hatfield, Kimberley Joanne; Tvedt, Tor Henrik Anderson; Reikvam, Håkon; Bruserud, Øystein (Peer reviewed; Journal article, 2018-09-14)
      Clonal heterogeneity detected by karyotyping is a biomarker associated with adverse prognosis in acute myeloid leukemia (AML). Constitutive activation of the phosphatidylinositol-3-kinase-Akt-mechanistic target of rapamycin ...