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    • COVID-19 pandemic and mortality in nursing homes across USA and Europe up to October 2021 

      Aalto, Ulla L.; Pitkala, Kaisu H; Andersen-Ranberg, Karen; Bonin-Guillaume, Sylvie; Cruz-Jentoft, Alfonso J.; Eriksdotter, Maria; Gordon, Adam; Gosch, Markus; Holmerova, Iva; Kautiainen, Hannu; Kivipelto, Miia; Macijauskiene, Jurate; O’Neill, Desmond; Van Den Noortgate, Nele; Ranhoff, Anette Hylen; Schols, Jos M. G. A.; Singler, Katrin; Stankunas, Mindaugas; Ouslander, Joseph G. (Journal article; Peer reviewed, 2022)
      Purpose: We compared the prevalence of COVID-19 and related mortality in nursing homes (NHs) in 14 countries until October 2021. We explored the relationship between COVID-19 mortality in NHs with the average size of NHs ...

    • Cow Farmers’ Homes Host More Diverse Airborne Bacterial Communities Than Pig Farmers’ Homes and Suburban Homes 

      Abouelhana, Hesham Amin Mohamed; Šantl-Temkiv, Tina; Cramer, Christine; Vestergaard, Ditte V.; Holst, Gitte J.; Elholm, Grethe; Finster, Kai; Bertelsen, Randi Jacobsen; Schlünssen, Vivi; Sigsgaard, Torben; Marshall, Ian P. G. (Journal article; Peer reviewed, 2022)
      Living on a farm has been linked to a lower risk of immunoregulatory disorders, such as asthma, allergy, and inflammatory bowel disease. It is hypothesized that a decrease in the diversity and composition of indoor microbial ...

    • The COX- inhibitor indomethacin reduces Th1 effector and T regulatory cells in vitro in Mycobacterium tuberculosis infection 

      Tonby, Kristian; Wergeland, Ida; Lieske, Nora Valeska; Kvale, Dag; Tasken, Kjetil; Dyrhol-Riise, Anne Ma (Peer reviewed; Journal article, 2016-10-24)
      Background: Tuberculosis (TB) causes a major burden on global health with long and cumbersome TB treatment regimens. Host-directed immune modulating therapies have been suggested as adjunctive treatment to TB antibiotics. ...

    • Creatinine, total cysteine and uric acid are associated with serum retinol in patients with cardiovascular disease 

      Olsen, Thomas; Vinknes, Kathrine; Blomhoff, Rune; Lysne, Vegard; Midttun, Øivind; Dhar, Indu; Ueland, Per Magne; Svingen, Gard Frodahl Tveitevåg; Pedersen, Eva Ringdal; Drevon, Christian A; Refsum, Helga; Nygård, Ottar (Peer reviewed; Journal article, 2019-09-09)
      Purpose: We hypothesized that biomarkers and dietary factors related to cardiovascular disease risk were associated with serum retinol and evaluated these potential associations in patients with suspected coronary artery ...

    • A critical appraisal of the evidence for using cardiotocography plus ECG ST interval analysis for fetal surveillance in labor. Part I: The randomized controlled trials 

      Olofsson, Per; Ayres-de-Campos, Diogo; Kessler, Jörg; Tendal, Britta; Yli, Branislava Markovic; Devoe, Lawrence (Peer reviewed; Journal article, 2014-06)
      We reappraised the five randomized controlled trials that compared cardiotocography plus ECG ST interval analysis (CTG+ST) vs. cardiotocography. The numbers enrolled ranged from 5681 (Dutch randomized controlled trial) to ...

    • A critical appraisal of the evidence for using cardiotocography plus ECG ST interval analysis for fetal surveillance in labor. Part II: The meta-analyses 

      Olofsson, Per; Ayres-de-Campos, Diogo; Kessler, Jörg; Tendal, Britta; Yli, Branislava Markovic; Devoe, Lawrence (Peer reviewed; Journal article, 2014-06)
      We appraised the methodology, execution and quality of the five published meta-analyses that are based on the five randomized controlled trials which compared cardiotocography (CTG)+ST analysis to cardiotocography. The ...

    • Critical evaluation of the appetite test for children with severe acute malnutrition 

      Zangenberg, Mike; Abdissa, Alemseged; Johansen, Øystein Haarklau; Tesfaw, Getnet; Friis, Henrik; Briend, André; Eshetu, Beza; Kurtzhals, Jørgen Anders Lindholm; Girma, Tsinuel (Peer reviewed; Journal article, 2020)
      OBJECTIVES: The appetite test is used to risk-stratify for children with severe acute malnutrition (SAM) in in-patient or out-patient care. The test is recommended in guidelines despite lack of evidence. We evaluated its ...

    • Cross-reactivity of the CEDIA buprenorphine assay in drugs-of-abuse screening: influence of dose and metabolites of opioids 

      Berg, Jon Andsnes; Schjøtt, Jan; Fossan, Kjell Ove; Riedel, Bettina (Peer reviewed; Journal article, 2015-10-28)
      Purpose: The cloned enzyme donor immunoassay (CEDIA) for buprenorphine is applied for both urine drugs-of-abuse screening and compliance monitoring. Sensitivity, specificity, and optimal cutoff of this assay have differed ...

    • Cross-Species Functional Genomic Analysis Identifies Resistance Genes of the Histone Deacetylase Inhibitor Valproic Acid 

      Forthun, Rakel Brendsdal; SenGupta, Tanima; Skjeldam, Hanne Kim; Lindvall, Jessica Margareta; McCormack, Emmet; Gjertsen, Bjørn Tore (Peer reviewed; Journal article, 2012-11-14)
      The mechanisms of successful epigenetic reprogramming in cancer are not well characterized as they involve coordinated removal of repressive marks and deposition of activating marks by a large number of histone and DNA ...

    • Cross-trait genome-wide association analysis of C-reactive protein level and psychiatric disorders 

      Hindley, Guy; Drange, Ole Kristian; Lin, Aihua; Kutrolli, Gleda; Shadrin, Alexey; Parker, Nadine; O'Connell, Kevin Sean; Rødevand, Linn; Cheng, Weiqiu; Bahrami, Shahram; Karadag, Naz; Holen, Børge; Jaholkowski, Piotr Pawel; Woldeyohannes, Markos Tesfaye; Djurovic, Srdjan; Dale, Anders M.; Frei, Oleksandr; Ueland, Thor; Smeland, Olav Bjerkehagen; Andreassen, Ole (Journal article; Peer reviewed, 2023)
      C-reactive protein (CRP) tends to be elevated in individuals with psychiatric disorders. Recent findings have suggested a protective effect of the genetic liability to elevated CRP on schizophrenia risk and a causative ...

    • Crosstalk between HSF1 and HSF2 during the heat shock response in mouse testes 

      Korfanty, Joanna; Stokowy, Tomasz; Widlak, Piotr; Gogler-Piglowska, Agnieszka; Handschuh, Luiza; Podkowinski, Jan; Vydra, Natalia; Naumowicz, Anna; Toma-Jonik, Agnieszka; Widlak, Wieslawa (Peer reviewed; Journal article, 2014-12)
      Heat Shock Factor 1 (HSF1) is the primary transcription factor responsible for the response to cellularstress, while HSF2 becomes activated during development and differentiation, including spermatogen-esis. Although both ...

    • Cryoballoon vs. radiofrequency catheter ablation: insights from NOrwegian randomized study of PERSistent Atrial Fibrillation (NO-PERSAF study) 

      Shi, Libin; Rossvoll, Ole; Tande, Pål Morten; Schuster, Peter Moritz; Solheim, Eivind; Chen, Jian (Journal article; Peer reviewed, 2022)
      Aims Pulmonary vein isolation (PVI) is still regarded as a cornerstone for treatment of persistent atrial fibrillation (AF). This study evaluated the effectiveness of PVI performed with cryoballoon ablation (CBA) in ...

    • Cryptosporidiosis in low-resource healthcare settings : Near-patient diagnostics, risk factors, and parasite shedding dynamics in young Ethiopian children 

      Johansen, Øystein Haarklau (Doctoral thesis, 2023-04-28)
      Bakgrunn: Tarmparasitten Cryptosporidium er en ledende årsak til diaré og dødsfall hos småbarn i lavinntektsland. Målretta behandling trengs, men forutsetter presise diagnostiske tester som er egna for ressursfattige ...

    • Cryptosporidium Infections in Africa—How Important Is Zoonotic Transmission? A Review of the Evidence 

      Robertson, Lucy; Johansen, Øystein Haarklau; Tesama, Tsegabirhan K Yohannes; Efunshile, Akinwale Michael; Terefe, Getachew (Journal article; Peer reviewed, 2020)
      Cryptosporidium, a protozoan parasite in the phylum Apicomplexa, is the etiological agent of cryptosporidiosis, an intestinal infection characterized by profuse watery diarrhea. Over 30 species of Cryptosporidium are ...

    • CT-defined emphysema in COPD patients and risk for change in desaturation status in 6-min walk test 

      Wåtevik, Marie; Frisk, Bente; Real, Francisco Gomez; Hardie, Jon Andrew; Bakke, Per; Eagan, Tomas Mikal Lind; Johannessen, Ane (Journal article; Peer reviewed, 2021)
      Background Emphysema and exercise induced desaturation (EID) are both related to poorer COPD prognosis. More knowledge of associations between emphysema and desaturation is needed for more efficient disease management. ...

    • ctDNA detected by ddPCR reveals changes in tumour load in metastatic malignant melanoma treated with bevacizumab 

      Forthun, Rakel Brendsdal; Hovland, Randi; Schuster, Cornelia; Puntervoll, Hanne Eknes; Brodal, Hans Petter; Namløs, Heidi Maria; Aasheim, Lars Birger; Meza, Leonardo Zepeda; Gjertsen, Bjørn Tore; Knappskog, Stian; Straume, Oddbjørn (Peer reviewed; Journal article, 2019)
      Bevacizumab is included in an increasing number of clinical trials. To find biomarkers to predict and monitor treatment response, cancer and angiogenesis relevant mutations in tumour and circulating tumour DNA (ctDNA) were ...

    • CTLA-4 as a genetic determinant in autoimmune Addison's disease 

      Wolff, Anette Susanne Bøe; Mitchell, Anna L.; Cordell, Heather J.; Short, Andrea; Skinningsrud, Beate; Ollier, William; Badenhoop, Klaus; Meyer, Gesine; Falorni, Alberto; Kämpe, Olle; Undlien, Dag Erik; Pearce, Simon H.S.; Husebye, Eystein Sverre (Peer reviewed; Journal article, 2015)
      In common with several other autoimmune diseases, autoimmune Addison’s disease (AAD) is thought to be caused by a combination of deleterious susceptibility polymorphisms in several genes, together with undefined environmental ...

    • Current evidence on the impact of medication optimization or pharmacological interventions on frailty or aspects of frailty: a systematic review of randomized controlled trials 

      Pazan, Farhad; Petrovic, Mirko; Cherubini, Antonio; Onder, Graziano; Cruz-Jentoft, Alfonso J.; Denkinger, Michael D.; van der Cammen, Tischa J. M.; Stevenson, Jennifer M.; Ibrahim, Kinda; Rajkumar, Chakravarthi; Bakken, Marit Stordal; Baeyens, Jean-Pierre; Crome, Peter; Frühwald, Thomas; Gallaghar, Paul; Guðmundsson, Adalsteinn; Knol, Wilma; O’Mahony, Denis; Pilotto, Alberto; Rönnemaa, Elina; Serra-Rexach, José Antonio; Soulis, George; van Marum, Rob J.; Ziere, Gijsbertus; Mair, Alpana; Burkhardt, Heinrich; Neumann-Podczaska, Agnieszka; Wieczorowska-Tobis, Katarzyna; Fernandes, Marilia Andreia; Gruner, Heidi; Dallmeier, Dhayana; Beuscart, Jean-Baptiste; Van Der Velde, Nathalie; Wehling, Martin (Journal article; Peer reviewed, 2021)
      Background Frailty and adverse drug effects are linked in the fact that polypharmacy is correlated with the severity of frailty; however, a causal relation has not been proven in older people with clinically manifest ...

    • Current transfusion practice and need for new blood products to ensure blood supply for patients with major hemorrhage in Europe 

      Apelseth, Torunn Oveland; Doyle, Barry; Evans, Ryan; George, Chloe; Humbrecht, Catherine; Klei, Thomas; Najdovski, Tome; Sigurjonsson, Olafur E.; Wiltshire, Michael; de Korte, Dirk (Journal article; Peer reviewed, 2023)
      Background: New blood products are considered for treatment of patients with major hemorrhage. The aim of this report is to describe the current transfusion practices in Europe for patients with major hemorrhage and explore ...

    • The curse of the uncultured fungus 

      Abarenkov, Kessy; Kristiansson, Erik; Ryberg, Martin; Nogal-Prata, Sandra; Gómez-Martínez, Daniela; Stüer-Patowsky, Katrin; Jansson, Tobias; Põlme, Sergei; Ghobad-Nejhad, Masoomeh; Corcoll, Natàlia; Scharn, Ruud; Sánchez-García, Marisol; Khomich, Maryia; Wurzbacher, Christian; Nilsson, R. Henrik (Journal article; Peer reviewed, 2022)
      The international DNA sequence databases abound in fungal sequences not annotated beyond the kingdom level, typically bearing names such as “uncultured fungus”. These sequences beget low-resolution mycological results and ...