Blar i Department of Clinical Science på tittel

Viser treff 1526-1545 av 2310

    • A novel concentrated, interdisciplinary group rehabilitation program for patients with chronic obstructive pulmonary disease: Protocol for a nonrandomized clinical intervention study 

      Frisk, Bente; Njøten, Kiri Lovise; Aarli, Bernt Bøgvald; Hystad, Sigurd William; Rykken, Sidsel; Kjosås, Ane; Søfteland, Eirik; Kvale, Gerd (Journal article; Peer reviewed, 2022)
      Background: Pulmonary rehabilitation has been demonstrated to be a highly effective treatment for people with chronic obstructive pulmonary disease (COPD). However, its availability is scarce worldwide, and new and ...

    • A novel disorder involving dyshematopoiesis, inflammation, and HLH due to aberrant CDC42 function 

      Lam, M.; Coppola, S.; Krumbach, Oliver H.F.; Prencipe, Giuseppe; Insalaco, Antonella; Cifaldi, C.; Brigida, I.; Zara, Erika; Scala, Serena; Di Cesare, Silvia; Martinelli, Simone; Di Rocco, Martina; Pascarella, Antonia; Niceta, Marcello; Pantaleoni, Francesca; Ciolfi, Andrea; Netter, Petra; Carisey, Alexandre; Diehl, Michael; Akbarzadeh, Mohammad; Conti, Francesca; Merli, Pietro; Pastore, Anna; Mortera, Stefano Levi; Camerini, Serena; Farina, L; Buchholzer, Marcel; Pannone, L.; Cao, T.; Coban-Akdemir, Zeynep H.; Jhangiani, Shalini N.; Muzny, Donna M.; Gibbs, Richard A.; Basso-Ricci, L.; Chiriaco, M.; Dvorsky, Radovan; Putignani, L.; Carsetti, Rita; Janning, Petra; Stray-Pedersen, Asbjørg; Erichsen, Hans Christian; Horne, AnnaCarin; Bryceson, Yenan; Torralba-Raga, Lamberto; Ramme, Kim; Rosti, Vittorio; Bracaglia, Claudia; Messia, Virginia; Palma, Paolo; Finocchi, Andrea; Lupski, James R. (Peer reviewed; Journal article, 2019)
      Hemophagocytic lymphohistiocytosis (HLH) is characterized by immune dysregulation due to inadequate restraint of overactivated immune cells and is associated with a variable clinical spectrum having overlap with more common ...

    • Novel endoscopic and MRI-based methods for evaluating exocrine pancreatic function in pancreatitis and monogenic forms of diabetes 

      Tjora, Erling (Doctoral thesis, 2013-11-15)
      Background: Monogenic diabetes (Maturity onset diabetes in the young, MODY) are autosomal dominantly inherited diabetes syndromes characterized by diabetes due to beta cell dysfunction, with typical onset of diabetes before ...

    • A novel fibrosis index comprising a non-cholesterol sterol accurately predicts HCV-related liver cirrhosis 

      Ydreborg, Magdalena; Lisovskaja, Vera; Lagging, Martin; Christensen, Peer Brehm; Langeland, Nina; Buhl, Mads Rauning; Pedersen, Court; Mørch, Kristine; Wejstål, Rune; Norkrans, Gunnar; Lindh, Magnus; Färkkilä, Martti; Westin, Johan (Peer reviewed; Journal article, 2014-04-03)
      Diagnosis of liver cirrhosis is essential in the management of chronic hepatitis C virus (HCV) infection. Liver biopsy is invasive and thus entails a risk of complications as well as a potential risk of sampling error. ...

    • A novel Geriatric Assessment frailty score predicts two-year mortality after Transcatheter Aortic Valve implantation 

      Skaar, Elisabeth; Eide, Leslie Sofia Pareja; Norekvål, Tone M.; Ranhoff, Anette Hylen; Nordrehaug, Jan Erik; Forman, Daniel E.; Schönenberger, Anders; Hufthammer, Karl Ove; Kuiper, Karel Kier-Jan; Bleie, Øyvind; Haaverstad, Rune; Schaufel, Margrethe Aase; Packer, Erik Jerome Stene; Langørgen, Jørund (Peer reviewed; Journal article, 2018-10-31)
      Aims Established surgical scores have limitations in delineating risk among candidates for transcatheter aortic valve implantation (TAVI). Assessment of frailty might help to estimate the mortality risk and identify patients ...

    • Novel inflammatory biomarkers in thyroid eye disease 

      Ueland, Hans Olav; Ueland, Grethe Åstrøm; Løvås, Kristian; Breivik, Lars Ertesvåg; Thrane, Alexander Stanley; Stokland, Ann-Elin Meling; Rødahl, Eyvind; Husebye, Eystein Sverre (Journal article; Peer reviewed, 2022)
      Purpose: The aim of this study is to identify biochemical inflammatory markers predicting the presence or risk of developing thyroid eye disease (TED) in patients with Graves' disease (GD). Methods: Patients with GD ...

    • Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits 

      Vogelezang, Suzanne; Bradfield, Jonathan P.; Ahluwalia, Tarunveer S.; Curtin, John A.; Lakka, Timo A.; Grarup, Niels; Scholz, Markus; van der Most, Peter J.; Monnereau, Claire; Stergiakouli, Evie; Heiskala, Anni; Horikoshi, Momoko; Fedko, Iryna O.; Vilor-Tejedor, Natalia; Cousminer, Diana L.; Standl, Marie; Wang, Carol A.; Viikari, Jorma; Geller, Frank; Íñiguez, Carmen; Pitkänen, Niina; Chesi, Alessandra; Bacelis, Jonas; Yengo, Loic; Torrent, Maties; Ntalla, Ioanna; Helgeland, Øyvind; Selzam, Saskia; Vonk, Judith M.; Zafarmand, Mohammed H.; Heude, Barbara; Farooqi, Ismaa Sadaf; Alyass, Akram; Beaumont, Robin N.; Have, Christian T.; Rzehak, Peter; Bilbao, Jose Ramon; Schnurr, Theresia M.; Barroso, Inês; Bønnelykke, Klaus; Beilin, Lawrence J.; Carstensen, Lisbeth; Charles, Marie-Aline; Chawes, Bo; Clément, Karine; Closa-Monasterolo, Ricardo; Custovic, Adnan; Eriksson, Johan G.; Vaudel, Marc; Njølstad, Pål Rasmus (Journal article; Peer reviewed, 2020)
      The genetic background of childhood body mass index (BMI), and the extent to which the well-known associations of childhood BMI with adult diseases are explained by shared genetic factors, are largely unknown. We performed ...

    • The novel microRNAs hsa-miR-nov7 and hsamiR- nov3 are over-expressed in locally advanced breast cancer 

      Poduval, Deepak; Sichmanovà, Zuzana; Straume, Anne Hege; Lønning, Per Eystein; Knappskog, Stian (Journal article; Peer reviewed, 2020)
      miRNAs are an important class of small non-coding RNAs, which play a versatile role in gene regulation at the post-transcriptional level. Expression of miRNAs is often deregulated in human cancers. We analyzed small RNA ...

    • Novel neonatal simulator provides high-fidelity ventilation training comparable to real-life newborn ventilation 

      Haynes, Joanna; Bjorland, Peder Aleksander; Gomo, Øystein; Ushakova, Anastasia; Rettedal, Siren; Perlman, Jeffrey M.; Ersdal, Hege Langli (Journal article; Peer reviewed, 2021)
      Face mask ventilation of apnoeic neonates is an essential skill. However, many non-paediatric healthcare personnel (HCP) in high-resource childbirth facilities receive little hands-on real-life practice. Simulation training ...

    • Novel PCDH10-Wnt-MALAT1 regulatory axis in endometrioid endometrial adenocarcinoma 

      Zhao, Y.; Yang, Y.; Trovik, Jone; Sun, Kun; Zhou, Liang; Jiang, Peiyong; Lau, Tatsan; Høivik, Erling Andre; Salvesen, Helga; Sun, H.; Wang, H. (Peer reviewed; Journal article, 2019)
      Key Messages: 1. Protocadherin 10 (PCDH10) is silenced in endometrioid endometrial cancer through promoter hypermethylation. 2. Ectopic expression of PCDH10 inhibits tumour growth and induces cell apoptosis. 3. Transcriptomic ...

    • Novel preoperative biomarkers and evaluation of altered treatment strategies to improve outcome for endometrial cancer patients 

      Forsse, David (Doctoral thesis, 2021-10-01)
      Background: Endometrial cancer is the most common gynecological cancer among women in countries with a high developmental index, and the incidence is expected to rise. Major controversies in the treatment of endometrial ...

    • A Novel Prophylaxis Strategy Using Liposomal Vaccine Adjuvant CAF09b Protects against Influenza Virus Disease 

      Zimmermann, Julie; Schmidt, Signe Tandrup; Trebbien, Ramona; Cox, Rebecca Jane; Zhou, Fan; Follmann, Frank; Pedersen, Gabriel Kristian; Christensen, Dennis (Journal article; Peer reviewed, 2022-02-06)
      The SARS-CoV-2 pandemic caused a massive health and societal crisis, although the fast development of effective vaccines reduced some of the impact. To prepare for future respiratory virus pandemics, a pan-viral prophylaxis ...

    • Novel RAB27A Variant Associated with Late-Onset Hemophagocytic Lymphohistiocytosis Alters Effector Protein Binding 

      Zondag, Timo C. E.; Torralba-Raga, Lamberto; Van Laar, Jan A. M.; Hermans, Maud A. W.; Bouman, Arjen; Hollink, Iris H. I. M.; Van Hagen, P. Martin; Briggs, Deborah A.; Hume, Alistair N.; Bryceson, Yenan (Journal article; Peer reviewed, 2022)
      Autosomal recessive mutations in RAB27A are associated with Griscelli syndrome type 2 (GS2), characterized by hypopigmentation and development of early-onset, potentially fatal hemophagocytic lymphohistiocytosis (HLH). We ...

    • Novel Reclassification of Adult Diabetes Is Useful to Distinguish Stages of β-Cell Function Linked to the Risk of Vascular Complications: The DOLCE Study From Northern Ukraine 

      Fedotkina, Olena; Sulaieva, Oksana; Özgümüs, Türküler; Cherviakova, Liubov; Khalimon, Nadiya; Svietleisha, Tetiana; Buldenko, Tetiana; Ahlqvist, Emma; Asplund, Olof; Groop, Leif; Nilsson, Peter M.; Lyssenko, Valeriya (Journal article; Peer reviewed, 2021)
      Background: Presently, persons with diabetes are classified as having type 1 (T1D) or type 2 diabetes (T2D) based on clinical diagnosis. However, adult patients exhibit diverse clinical representations and this makes ...

    • A novel splice-affecting HNF1A variant with large population impact on diabetes in Greenland 

      Thuesen, Anne Cathrine; Stæger, Fredrik Filip; Kaci, Alba; Solheim, Marie Holm; Aukrust, Ingvild; Jørsboe, Emil; Santander, Cindy G.; Andersen, Mette; Li, Zilong; Gilly, Arthur; Stinson, Sara Elizabeth; Gjesing, Anette Prior; Bjerregaard, Peter; Pedersen, Michael Lynge; Larsen, Christina Viskum Lytken; Grarup, Niels; Jørgensen, Marit E.; Zeggini, Eleftheria; Bjørkhaug, Lise; Njølstad, Pål Rasmus; Albrechtsen, Anders; Moltke, Ida; Hansen, Torben (Journal article; Peer reviewed, 2023)
      Background: The genetic disease architecture of Inuit includes a large number of common high-impact variants. Identification of such variants contributes to our understanding of the genetic aetiology of diseases and improves ...

    • Novel STAT3 Inhibitors Targeting STAT3 Dimerization by Binding to the STAT3 SH2 Domain 

      Hua, Yaping; Yuan, Xing; Shen, Yun-Heng; Wang, Jinxin; Azeem, Waqas; Yang, Shuo; Gade, Alexandra; Lellahi, Seyed Mohammad; Øyan, Anne Margrete; Ke, Xisong; Zhang, Wei-Dong; Kalland, Karl Henning (Journal article; Peer reviewed, 2022)
      Our drug discovery model has identified two novel STAT3 SH2 domain inhibitors 323–1 and 323–2 (delavatine A stereoisomers) in a series of experiments. In silico computational modeling, drug affinity responsive target ...

    • Novel transcriptional signatures for sputum-independent diagnostics of tuberculosis in children 

      Gjøen, John Espen; Jenum, Synne; Sivakumaran, Dhanasekaran; Mukherjee, Aparna; MacAden, Ragini; Kabra, Sushil K.; Lodha, Rakesh; Ottenhoff, Tom H.M.; Haks, Marielle C.; Doherty, Timothy Mark; Ritz, Christian; Grewal, Harleen (Peer reviewed; Journal article, 2017-07-19)
      Pediatric tuberculosis (TB) is challenging to diagnose, confirmed by growth of Mycobacterium tuberculosis at best in 40% of cases. The WHO has assigned high priority to the development of non-sputum diagnostic tools. We ...

    • A novel, single-amplification PCR targeting mitochondrial genome highly sensitive and specific in diagnosing malaria among returned travellers in Bergen, Norway 

      Haanshuus, Christel Gill; Mohn, Stein Christian; Mørch, Kristine; Langeland, Nina; Blomberg, Bjørn; Hanevik, Kurt (Peer reviewed; Journal article, 2013-01-22)
      Background: Nested PCR is a commonly used technique in diagnosis of malaria owing to its high sensitivity and specificity. However, it is time-consuming, open to considerable risk of contamination and has low cost-efficiency. ...

    • A novel, single-amplification PCR targeting mitochondrial genome highly sensitive and specific in diagnosing malaria among returned travellers in Bergen, Norway 

      Haanshuus, Christel Gill; Mohn, Stein Christian; Mørch, Kristine; Langeland, Nina; Blomberg, Bjørn; Hanevik, Kurt (Peer reviewed; Journal article, 2013-01-22)
      Background: Nested PCR is a commonly used technique in diagnosis of malaria owing to its high sensitivity and specificity. However, it is time-consuming, open to considerable risk of contamination and has low cost-efficiency. ...

    • NPM1-Mutated Patient-Derived AML Cells Are More Vulnerable to Rac1 Inhibition 

      Hemsing, Anette Lodvir; Rye, Kristin Paulsen; Hatfield, Kimberley Joanne; Reikvam, Håkon (Journal article; Peer reviewed, 2022)
      The prognosis of acute myeloid leukemia (AML) is poor, especially for the elderly population. Targeted therapy with small molecules may be a potential strategy to overcome chemoresistance and improve survival in AML. We ...