Blar i Department of Clinical Science på emneord "Chronic obstructive pulmonary disease"

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    • Airway obstruction, dynamic hyperinflation, and breathing pattern during incremental exercise in COPD patients 

      Frisk, Bente; Espehaug, Birgitte; Hardie, Jon Andrew; Strand, Liv Inger; Moe-Nilssen, Rolf; Eagan, Tomas Mikal; Bakke, Per; Thorsen, Einar (Peer reviewed; Journal article, 2014-02-01)
      Ventilatory capacity is reduced in chronic obstructive pulmonary disease (COPD) patients. Tidal volume (VT) is lower and breathing frequency higher at a given ventilation (VE) compared to healthy subjects. We examined ...

    • A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry 

      Lutz, Sharon M; Cho, Michael H; Young, Kendra; Hersh, Craig P; Castaldi, Peter J; McDonald, Merry-Lynn; Regan, Elizabeth; Mattheisen, Manuel; DeMeo, Dawn L; Parker, Margaret; Foreman, Marilyn; Make, Barry J; Jensen, Robert L; Casaburi, Richard; Lomas, David A; Bhatt, Surya P; Bakke, Per; Gulsvik, Amund; Crapo, James D; Beaty, Terri H; Laird, Nan M; Lange, Christoph; Hokanson, John E; Silverman, Edwin K (Peer reviewed; Journal article, 2015-12-03)
      Background Pulmonary function decline is a major contributor to morbidity and mortality among smokers. Post bronchodilator FEV1 and FEV1/FVC ratio are considered the standard assessment of airflow obstruction. We performed ...

    • Nitric oxide synthase polymorphisms, gene expression and lung function in chronic obstructive pulmonary disease 

      Aminuddin, Farzian; Hackett, Tillie-Louise; Stefanowicz, Dorota; Saferali, Aabida; Paré, Peter D.; Gulsvik, Amund; Bakke, Per; Cho, Michael H.; Litonjua, Augusto A.; Lomas, David A.; Anderson, Wayne H.; Beaty, Terri H.; Silverman, Edwin K.; Sandford, Andrew J. (Peer reviewed; Journal article, 2013-11-06)
      Background: Due to the pleiotropic effects of nitric oxide (NO) within the lungs, it is likely that NO is a significant factor in the pathogenesis of chronic obstructive pulmonary disease (COPD). The aim of this study was ...