Blar i Department of Clinical Science på emneord "Epigenetics"
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Analysis of differentially methylated regions in great apes and extinct hominids provides support for the evolutionary hypothesis of schizophrenia
(Peer reviewed; Journal article, 2018-12-11)Introduction: The persistence of schizophrenia in human populations separated by geography and time led to the evolutionary hypothesis that proposes schizophrenia as a by-product of the higher cognitive abilities of modern ... -
Maternal smoking impacts key biological pathways in newborns through epigenetic modification in Utero
(Peer reviewed; Journal article, 2016-11-25)Background: Children exposed to maternal smoking during pregnancy exhibit increased risk for many adverse health effects. Maternal smoking influences methylation in newborns at specific CpG sites (CpGs). Here, we extend ... -
Recently evolved human-specific methylated regions are enriched in schizophrenia signals
(Peer reviewed; Journal article, 2018)Background: One explanation for the persistence of schizophrenia despite the reduced fertility of patients is that it is a by-product of recent human evolution. This hypothesis is supported by evidence suggesting that ...