Now showing items 1-20 of 448

    • Parents’ Attitudes toward Clinical Genetic Testing for Autism Spectrum Disorder—Data from a Norwegian Sample 

      Johannessen, Tor Jarle; Nærland, Terje; Hope, Sigrun; Torske, Tonje; Høyland, Anne Lise; Strohmaier, Jana; Heiberg, Arvid; Rietschel, Marcella; Djurovic, Srdjan; Andreassen, Ole Andreas (MDPI, 2017-05-18)
      Clinical genetic testing (CGT) of children with autism spectrum disorder (ASD) may have positive and negative effects. Knowledge about parents’ attitudes is needed to ensure good involvement of caregivers, which is crucial ...
      Journal article
    • Genetic variation in 117 myelination-related genes in schizophrenia: Replication of association to lipid biosynthesis genes 

      Stokowy, Tomasz; Polushina, Tatiana; Sønderby, Ida Elken; Karlsson, Robert; Giddaluru, Sudheer; Le Hellard, Stephanie; Bergen, Sarah E; Sullivan, Patrick F; Andreassen, Ole Andreas; Djurovic, Srdjan; Hultman, Christina M.; Steen, Vidar Martin (Nature Publishing Group, 2018-05-02)
      Schizophrenia is a serious psychotic disorder with high heritability. Several common genetic variants, rare copy number variants and ultra-rare gene-disrupting mutations have been linked to disease susceptibility, but there ...
      Journal article
    • Paternal and maternal obesity but not gestational weight gain is associated with type 1 diabetes 

      Magnus, Maria Christine; Olsen, Sjurdur Frodi; Granström, Charlotta; Lund-Blix, Nicolai Andre; Svensson, Jannet; Johannesen, Jesper; Fraser, Abigail; Skrivarhaug, Torild; Joner, Geir; Njølstad, Pål Rasmus; Størdal, Ketil; Stene, Lars Christian Mørch (Oxford University Press, 2018-04)
      Background Our objective was to examine the associations of parental body mass index (BMI) and maternal gestational weight gain with childhood-onset type 1 diabetes. Comparing the associations of maternal and paternal BMI ...
      Journal article
    • Primary aldosteronism in Western Norway. Studies of diagnostic approach and treatment outcome 

      Grytaas, Marianne Aardal (The University of Bergen, 2018-09-06)
      Primary aldosteronism (PA) is the most common cause of secondary hypertension (HT), accounting for 5 to 12% of all hypertensive individuals. Patients with PA experience increased cardiovascular, renal and metabolic ...
      Doctoral thesis
    • Cardiac magnetic resonance imaging of myocardial mass and fibrosis in primary aldosteronism 

      Grytaas, Marianne; Sellevåg, Kjersti; Thordarson, Hrafnkell B; Husebye, Eystein Sverre; Løvås, Kristian; Larsen, Terje H (Bioscientifica, 2018-03)
      Background: Primary aldosteronism (PA) is associated with increased cardiovascular morbidity, presumably due to left ventricular (LV) hypertrophy and fibrosis. However, the degree of fibrosis has not been extensively ...
      Journal article
    • Transcapillary fluid balance in children. Methodology and new clinical studies. To the interstitial space - and back again 

      Guthe, Hans Jørgen Timm (The University of Bergen, 2016-04-29)
      Objective: The capillaries represent a semipermeable barrier between the blood and the interstitium, where there is a continuous exchange of fluid and solutes. Numerous factors affect the tight regulation of this movement ...
      Doctoral thesis
    • Transcapillary fluid flux and inflammatory response during neonatal therapeutic hypothermia: an open, longitudinal, observational study 

      Guthe, Hans Jørgen Timm; Nedrebø, Torbjørn; Damås, Jan Kristian; Wiig, Helge; Berg, Ansgar (BioMed Central, 2018-02-23)
      Background: Therapeutic hypothermia is neuroprotective in asphyxiated neonates by counteracting mechanisms contributing to brain injury. Although an initial increased permeability is part of an inflammatory reaction ...
      Journal article
    • Limited Benefit of Fish Consumption on Risk of Hip Fracture among Men in the Community-Based Hordaland Health Study 

      Rosendahl-Riise, Hanne; Sulo, Gerhard; Karlsson, Therese; Drevon, Christian A.; Dierkes, Jutta; Tell, Grethe S. (MDPI, 2018-07-06)
      Hip fractures have a high prevalence worldwide. Few studies have investigated whether fish consumption is associated with risk of hip fractures. The objective of the present study was to investigate the effect of fish ...
      Journal article
    • Dietary predictors of bone mineral density, hip fractures, mobility and muscle strength - in community-dwelling older persons 

      Rosendahl-Riise, Hanne (The University of Bergen, 2018-10-23)
      Background: The aging process involves decline of both muscle and bone mass. The loss of muscle mass is associated with decreased muscle strength and mobility, while loss of bone mass leads to osteoporosis and increased ...
      Doctoral thesis
    • An evolutionary epigenetics approach to schizophrenia 

      Banerjee, Niladri (The University of Bergen, 2018-09-28)
      Schizophrenia is a psychotic disorder with an estimated lifetime prevalence of ~1% worldwide. Despite reduced fecundity of patients, this rate is stable across population groups separated by geography and time. There is ...
      Doctoral thesis
    • Recently evolved human-specific methylated regions are enriched in schizophrenia signals 

      Banerjee, Niladri; Polushina, Tatiana; Bettella, Francesco; Giddaluru, Sudheer; Steen, Vidar Martin; Andreassen, Ole Andreas; Le Hellard, Stephanie (BioMed Central, 2018)
      Background: One explanation for the persistence of schizophrenia despite the reduced fertility of patients is that it is a by-product of recent human evolution. This hypothesis is supported by evidence suggesting that ...
      Journal article
    • In vitro characterization of six STUB1 variants in spinocerebellar ataxia 16 reveals altered structural properties for the encoded CHIP proteins 

      Pakdaman, Yasaman; Sanchez Guixe, Monica; Kleppe, Rune; Erdal, Sigrid; Bustad, Helene J.; Bjørkhaug, Lise; Haugarvoll, Kristoffer; Tzoulis, Charalampos; Heimdal, Ketil Riddervold; Knappskog, Per; Johansson, Stefan; Aukrust, Ingvild (Portland Press, 2017)
      Spinocerebellar ataxia, autosomal recessive 16 (SCAR16) is caused by biallelic mutations in the STIP1 homology and U-box containing protein 1 (STUB1) gene encoding the ubiquitin E3 ligase and dimeric co-chaperone C-terminus ...
      Journal article
    • Circulating concentrations of biomarkers and metabolites related to Vitamin status, one-carbon and the kynurenine pathways in US, Nordic, Asian, and Australian populations 

      Midttun, Øivind; Theofylaktopoulou, Despoina; Mccann, Adrian; Fanidi, Anouar; Muller, David C.; Meyer, Klaus; Ulvik, Arve; Zheng, Wei; Shu, Xiao-Ou; Xiang, Yong-Bing; Prentice, Ross; Thomson, Cynthia A.; Pettinger, Mary; Giles, Graham G.; Hodge, Allison; Cai, Qiuyin; Blot, William J.; Wu, Jie; Johansson, Mikael; Hultdin, Johan; Grankvist, Kjell; Stevens, Victoria L.; McCullough, Marjorie L.; Weinstein, Stephanie J.; Albanes, Demetrius; Langhammer, Arnulf; Hveem, Kristian; Næss, Marit; Sesso, Howard D.; Gaziano, J. Michael; Buring, Julie E.; Lee, I-Min; Severi, Gianluca; Zhang, Xuehong; Han, Jiali; Stampfer, Meir J.; Smith-Warner, Stephanie A.; Zeleniuch-Jacquotte, Anne; Le Marchand, Loic; Yuan, Jian-Min; Butler, Lesley M.; Koh, Woon-Puay; Wang, Renwei; Gao, Yu-Tang; Ericson, Ulrika; Sonestedt, Emily; Ziegler, Regina G.; Freedman, Neal D.; Visvanathan, Kala; Jones, Miranda R.; Relton, Caroline; Brennan, Paul; Johansson, Mattias; Ueland, Per Magne (Oxford University Press, 2017-06)
      Background: Circulating concentrations of biomarkers that are related to vitamin status vary by factors such as diet, fortification, and supplement use. Published biomarker concentrations have also been influenced by the ...
      Journal article
    • Identification of shared genetic variants between schizophrenia and lung cancer 

      Zuber, Verena; Jönsson, Erik Gunnar; Frei, Oleksandr; Witoelar, Aree; Thompson, V K; Schork, Andrew J; Bettella, Francesco; Wang, Yunpeng; Djurovic, Srdjan; Smeland, Olav Bjerkehagen; Dieset, Ingrid; Fanous, Ayman H.; Desikan, Rahul S; Küry, Sébastien; Bezieau, Stephane; Dale, Anders M; Mills, Ian Geoffrey; Andreassen, Ole Andreas (Nature Publishing Group, 2018-01-12)
      Epidemiology studies suggest associations between schizophrenia and cancer. However, the underlying genetic mechanisms are not well understood, and difficult to identify from epidemiological data. We investigated if there ...
      Journal article
    • Oral microbiota in autoimmune polyendocrine syndrome type 1 

      Bruserud, Øyvind; Siddiqui, Huma; Marthinussen, Michaela Cuida; Chen, Tsute; Jonsson, Roland; Oftedal, Bergithe Eikeland; Olsen, Ingar; Husebye, Eystein Sverre; Wolff, Anette Bøe (Taylor & Francis, 2018)
      Background: Autoimmune polyendocrine syndrome type-1 (APS-1) is a rare, childhood onset disease caused by mutations in the Autoimmune Regulator gene. The phenotypic expression is highly variable and includes disease ...
      Journal article
    • HIV-infected persons with type 2 diabetes show evidence of endothelial dysfunction and increased inflammation 

      Hove-Skovsgaard, Malene; Gaardbo, Julie Christine; Kolte, Lilian; Winding, Kamilla; Seljeflot, Ingebjørg; Svardal, Asbjørn M.; Berge, Rolf Kristian; Gerstoft, Jan; Ullum, Henrik; Trøseid, Marius; Nielsen, Susanne Dam (BioMed Central, 2017-03-29)
      Background: Increased incidence of cardiovascular diseases (CVD) in both HIV infection and type 2 diabetes (T2D) compared to the general population has been described. Little is known about the combined effect of HIV ...
      Journal article
    • Boosting of cross-reactive and protection-associated T cells in children after live attenuated influenza vaccination 

      Mohn, Kristin Greve Isdahl; Zhou, Fan; Brokstad, Karl Albert; Sridhar, Saranya; Cox, Rebecca Jane (Oxford University Press, 2017-05)
      Background. Live attenuated influenza vaccines (LAIVs) stimulate a multifaceted immune response including cellular immunity, which may provide protection against newly emerging strains. This study shows proof of concept ...
      Journal article
    • T cell receptor assessment in autoimmune disease requires access to the most adjacent immunologically active organ 

      Oftedal, Bergithe Eikeland; Ardesjo Lundgren, Brita; Hamm, David; Gan, Poh-Yi; Holdsworth, Stephen R; Hahn, Christopher N.; Schreiber, Andreas W.; Scott, Hamish S. (Elsevier, 2017-07)
      Next generation sequencing of T and B cell receptors is emerging as a valuable and effective method to diagnose and monitor hematopoietic malignancies. So far, this approach has not been fully explored in regard to autoimmune ...
      Journal article
    • CDC25 inhibition in acute myeloid leukemia - A study of patient heterogeneity and the effects of different inhibitors 

      Brenner, Annette; Reikvam, Håkon; Rye, Kristin Paulsen; Hagen, Karen Marie; Lavecchia, Antonio; Bruserud, Øystein (MDPI, 2017-03-11)
      Cell division cycle 25 (CDC25) protein phosphatases regulate cell cycle progression through the activation of cyclin-dependent kinases (CDKs), but they are also involved in chromatin modulation and transcriptional regulation. ...
      Journal article
    • Sarcopenia in patients with hip fracture. A multicenter prospective study with one-year follow-up 

      Steihaug, Ole Martin (The University of Bergen, 2018-09-11)
      Sarcopenia is a geriatric syndrome of reduced muscle mass and physical performance associated with falls, fractures, impairments in activities of daily living, and mortality. Hip fractures are fractures of the upper third ...
      Doctoral thesis