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dc.contributor.authorKmiecik, Justynaen_US
dc.contributor.authorZimmer, Jacquesen_US
dc.contributor.authorChekenya, Marthaen_US
dc.date.accessioned2014-01-14T09:57:48Z
dc.date.available2014-01-14T09:57:48Z
dc.date.issued2014-01eng
dc.PublishedJournal of Neuro-Oncology 116(1): 1-9eng
dc.identifier.issn1573-7373
dc.identifier.issn0167-594X
dc.identifier.urihttps://hdl.handle.net/1956/7669
dc.description.abstractNatural killer (NK) cells are lymphocytes that play an important role in anti-tumour immunity. Their potential against brain cancer has been demonstrated in vitro and in vivo, both as a direct anti-tumour agent and in experimental therapies stimulating endogenous NK cell cytotoxicity. However, the clinical translation of these promising results requires detailed knowledge about the immune status of brain tumour patients, with focus on the NK cell population. In this report, we provide an overview of the studies investigating NK cell infiltration into the tumour, emphasizing the need of revision of the methodologies and further research in this field. We also discuss the potential of using autologous or allogeneic NK cells as effector cells in cellular therapy against brain cancer and developing immunotherapies stimulating endogenous NK cell-mediated anti-tumour response, such as blocking inhibitory killer immunoglobulin-like receptors. Combination of NK cell adoptive transfer with targeted therapies, such as anti-EGFR therapeutic antibody (CetuximAb) could also be a potent strategy.en_US
dc.language.isoengeng
dc.publisherSpringereng
dc.relation.ispartof<a href="http://hdl.handle.net/1956/7670" target="blank">Immunological mechanisms of tumour progression. The rationale for natural killer cell based immunotherapy for glioblastoma</a>eng
dc.rightsAttribution CC BYeng
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/eng
dc.subjectTumour infiltrating lymphocyteseng
dc.subjectNK cellseng
dc.subjectBrain tumoureng
dc.subjectPrognosiseng
dc.subjectImmunotherapyeng
dc.titleNatural killer cells in intracranial neoplasms: presence and therapeutic efficacy against brain tumoursen_US
dc.typePeer reviewed
dc.typeJournal article
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2013 The Author(s)
dc.identifier.doihttps://doi.org/10.1007/s11060-013-1265-5
dc.identifier.cristin1126661
dc.source.journalJournal of Neuro-Oncology
dc.source.40116
dc.source.141
dc.source.pagenumber1-9


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