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dc.contributor.authorErsland, Kari Mereteen_US
dc.contributor.authorHåvik, Bjarteen_US
dc.contributor.authorRinholm, Johanne Eggeen_US
dc.contributor.authorGundersen, Vidaren_US
dc.contributor.authorStansberg, Christineen_US
dc.contributor.authorSteen, Vidar Martinen_US
dc.date.accessioned2014-03-18T08:35:34Z
dc.date.available2014-03-18T08:35:34Z
dc.date.issued2013-07-11eng
dc.identifier.issn1471-2202
dc.identifier.urihttps://hdl.handle.net/1956/7863
dc.description.abstractBackground: The neocortex is a highly specialised and complex brain structure, involved in numerous tasks, ranging from processing and interpretation of somatosensory information, to control of motor functions. The normal function linked to distinct neocortical areas might involve control of highly specific gene expression, and in order to identify such regionally enriched genes, we previously analysed the global gene expression in three different cortical regions (frontomedial, temporal and occipital cortex) from the adult rat brain. We identified distinct sets of differentially expressed genes. One of these genes, namely the hypothetical protein LOC689986 (LOC689986), was of particular interest, due to an almost exclusive expression in the temporal cortex. Results: Detailed analysis of LOC689986 in the adult rat brain confirmed the expression in confined areas of parieto-temporal cortex, and revealed highly specific expression in layer 4 of the somatosensory cortex, with sharp borders towards the neighbouring motor cortex. In addition, LOC689986 was found to be translated in vivo, and was detected in the somatosensory cortex and in the Purkinje cells of the cerebellar cortex. The protein was present in neuronal dendrites and also in astrocyte cells. Finally, this unique gene is apparently specific for, and highly conserved in, the vertebrate lineage. Conclusions: In this study, we have partially characterised the highly conserved LOC689986 gene, which is specific to the vertebrate linage. The gene displays a distinct pattern of expression in layer 4 of the somatosensory cortex, and areas of the parieto-temporal cortex in rodents.en_US
dc.language.isoengeng
dc.publisherBioMed Centraleng
dc.rightsAttribution CC BYeng
dc.rights.urihttp://creativecommons.org/licenses/by/2.0/eng
dc.subjectCerebellumeng
dc.subjectConservationeng
dc.subjectCortexeng
dc.subjectEnriched expressioneng
dc.subjectSomatosensoryeng
dc.titleLOC689986, a unique gene showing specific expression in restricted areas of the rodent neocortexen_US
dc.typePeer reviewed
dc.typeJournal article
dc.date.updated2013-08-23T08:36:36Z
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2013 Ersland et al.; licensee BioMed Central Ltd.
dc.rights.holderKari M Ersland et al.; licensee BioMed Central Ltd.
dc.source.articlenumber68
dc.identifier.doihttps://doi.org/10.1186/1471-2202-14-68
dc.identifier.cristin1051996
dc.source.journalBMC Neuroscience
dc.source.4014


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