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dc.contributor.authorFalkenberg, Liv Eggseteng
dc.contributor.authorWesterhausen, Renéeng
dc.contributor.authorCraven, Alexander R.eng
dc.contributor.authorKroken, Rune A.eng
dc.contributor.authorLøberg, Else-Marieeng
dc.contributor.authorSpecht, Karsteneng
dc.contributor.authorHugdahl, Kennetheng
dc.date.accessioned2014-04-30T08:27:29Zen_US
dc.date.accessioned2014-11-11T09:24:33Zen_US
dc.date.accessioned2014-12-10T09:06:00Z
dc.date.available2014-12-10T09:06:00Z
dc.date.issued2014-04-02eng
dc.identifier.urihttp://hdl.handle.net/1956/8873
dc.description.abstractSchizophrenia is characterized by impaired cognitive functioning, and brain regions involved in cognitive control processes show marked glutamatergic abnormalities. However, it is presently unclear whether aberrant neuronal response is directly related to the observed deficits at the metabolite level in schizophrenia. Here, 17 medicated schizophrenia patients and 17 matched healthy participants underwent functional magnetic resonance imaging (fMRI) when performing an auditory cognitive control task, as well as proton magnetic resonance spectroscopy (1H-MRS) in order to assess resting-state glutamate in the anterior cingulate cortex. The combined fMRI–1H-MRS analysis revealed that glutamate differentially predicted cortical blood-oxygen level-dependent (BOLD) response in patients and controls. While we found a positive correlation between glutamate and BOLD response bilaterally in the inferior parietal lobes in the patients, the corresponding correlation was negative in the healthy control participants. Further, glutamate levels predicted task performance in patients, such that lower glutamate levels were related to impaired cognitive control functioning. This was not seen for the healthy controls. These findings suggest that schizophrenia patients have a glutamate-related dysregulation of the brain network supporting cognitive control functioning. This could be targeted in future research on glutamatergic treatment of cognitive symptoms in schizophrenia.en_US
dc.language.isoengeng
dc.publisherElseviereng
dc.rightsAttribution-NonCommercial-NoDerivs CC BY-NC-NDeng
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/eng
dc.subjectCombined fMRI–MRSeng
dc.subject1H-MRSeng
dc.subjectCognitive controleng
dc.subjectAnterior cingulate cortexeng
dc.subjectInferior parietal lobeeng
dc.subjectGlutamateeng
dc.subjectBOLDeng
dc.subjectConnectivityeng
dc.titleImpact of glutamate levels on neuronal response and cognitive abilities in schizophreniaeng
dc.typeJournal articleeng
dc.date.updated2014-04-30T08:27:29Zen_US
dc.rights.holderCopyright 2014 The Authors
dc.type.versionpublishedVersioneng
bora.peerreviewedPeer reviewedeng
bora.journalTitleNeuroImage: Clinicaleng
bibo.volume4eng
bibo.pageStart576eng
bibo.pageEnd584eng
bibo.doihttp://dx.doi.org/10.1016/j.nicl.2014.03.014eng
bora.accessRightsinfo:eu-repo/semantics/openAccesseng
dc.identifier.cristinID1127932eng
dc.identifier.doi10.1016/j.nicl.2014.03.014
dc.source.issn1053-8119en_US
bora.bpoaIDbpoa114


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