Sleep and protein synthesis-dependent synaptic plasticity: impacts of sleep loss and stress
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Sleep has been ascribed a critical role in cognitive functioning. Several lines of evidence implicate sleep in the consolidation of synaptic plasticity and long-term memory. Stress disrupts sleep while impairing synaptic plasticity and cognitive performance. Here, we discuss evidence linking sleep to mechanisms of protein synthesis-dependent synaptic plasticity and synaptic scaling. We then consider how disruption of sleep by acute and chronic stress may impair these mechanisms and degrade sleep function.
CitationFrontiers in Behavioral Neuroscience
SubjectLong-term potentiationStressSleep deprivationmood disorderGene expressiontranslation controlbrain-derived neurotrophic factorArc/Arg3.1
Copyright 2014 Grønli, Soulé and Bramham.