Sleep and protein synthesis-dependent synaptic plasticity: impacts of sleep loss and stress
Peer reviewed, Journal article
Published version
Permanent lenke
https://hdl.handle.net/1956/8999Utgivelsesdato
2014-01-21Metadata
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Originalversjon
https://doi.org/10.3389/fnbeh.2013.00224Sammendrag
Sleep has been ascribed a critical role in cognitive functioning. Several lines of evidence implicate sleep in the consolidation of synaptic plasticity and long-term memory. Stress disrupts sleep while impairing synaptic plasticity and cognitive performance. Here, we discuss evidence linking sleep to mechanisms of protein synthesis-dependent synaptic plasticity and synaptic scaling. We then consider how disruption of sleep by acute and chronic stress may impair these mechanisms and degrade sleep function.