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dc.contributor.authorMazzawi, Tareken_US
dc.contributor.authorHausken, Trygveen_US
dc.contributor.authorGundersen, Dorisen_US
dc.contributor.authorEl-Salhy, Magdyen_US
dc.date.accessioned2014-12-23T12:41:13Z
dc.date.available2014-12-23T12:41:13Z
dc.date.issued2014-08-06eng
dc.identifier.issn0954-3007
dc.identifier.urihttps://hdl.handle.net/1956/9026
dc.description.abstractBackground/objectives: The gastric endocrine cells in patients with irritable bowel syndrome (IBS) tend to normalize following dietary guidance. The aim of the present study was to identify the gastric endocrine cell types that are changed following such dietary guidance. Subjects/methods: Fourteen IBS patients and 14 healthy subjects were included in the study. Patients received three sessions of individual dietary management guidance. Gastroscopy was performed on both the controls and the patients at baseline and then again for the patients at 3–9 months after dietary guidance. Biopsy samples from the corpus and antrum were immunostained for all gastric endocrine cell types. Endocrine cells were quantified by computerized image analysis. Results: The densities of the ghrelin cells for the controls and IBS patients before and after dietary guidance were 149.6±36.2 (mean±s.e.m.; 95% confidence interval (CI) 71.3–227.8), 114.5±32.7 and 161.8±37.8 cells/mm2, respectively. The densities of the gastrin cells in these groups were 155.8±21.0 (95% CI 110.3–201.2), 159.4±24.3 and 211.6±28.0 cells/mm2, respectively; the corresponding densities of serotonin cells in the corpus were 18.2±3.9 (95% CI 9.8–26.6), 10.6±3.4 and 14±2.0 cells/mm2 and in the antrum were 44.6±12.2 (95% CI 18.1–71.1), 1.7±0.5 and 14.7±6.3 cells/mm2. The densities of the somatostatin cells in the corpus were 40.0±7.7 (95% CI 23.5–56.5), 23.0±3.0 and 37.3±4.2 cells/mm2, respectively, and in the antrum were 138.9±22.0 (95% CI 91.4–186.3), 95.6±15.9 and 86.0±16.9 cells/mm2, respectively. Conclusions: The densities of all of the gastric endocrine cell types changed towards the healthy control values in the IBS patients following a change in food intake.en_US
dc.language.isoengeng
dc.publisherNature Publishing Groupeng
dc.relation.ispartof<a href="http://hdl.handle.net/1956/10371" target="blank">The Role of Diet in Irritable Bowel Syndrome with special reference to Gut Neuroendocrine System</a>
dc.rightsAttribution CC BYeng
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/eng
dc.titleEffect of dietary management on the gastric endocrine cells in patients with irritable bowel syndromeen_US
dc.typePeer reviewed
dc.typeJournal article
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2014 Macmillan Publishers Limited
dc.identifier.doihttps://doi.org/10.1038/ejcn.2014.151
dc.identifier.cristin1164795
dc.source.journalEuropean Journal of Clinical Nutrition


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