• Cholesterol-containing lipid nanodiscs promote an α-synuclein binding mode that accelerates oligomerization 

      Jakubec, Martin; Bariås, Espen; Furse, Samuel Robert; Govasli Larsen, Morten Andreas; George, Vinnit; Turcu, Diana Cornelia; Iashchishyn, Igor A.; Morozova-Roche, Ludmilla A.; Halskau, Øyvind (Journal article; Peer reviewed, 2021)
      Dysregulation of the biosynthesis of cholesterol and other lipids has been implicated in many neurological diseases, including Parkinson's disease. Misfolding of α-synuclein (α-Syn), the main actor in Parkinson's disease, ...
    • CHOPCHOP v2: a web tool for the next generation of CRISPR genome engineering 

      Valen, Eivind; Labun, Kornel; Montague, Tessa G.; Gagnon, James A.; Thyme, Summer B. (Journal article; Peer reviewed, 2016)
      In just 3 years CRISPR genome editing has transformed biology, and its popularity and potency continue to grow. New CRISPR effectors and rules for locating optimum targets continue to be reported, highlighting the need for ...
    • CHOPCHOP v3: expanding the CRISPR web toolbox beyond genome editing 

      Labun, Kornel; Montague, Tessa G.; Krause, Maximilian; Torres Cleuren, Yamila Nicole; Tjeldnes, Håkon; Valen, Eivind (Peer reviewed; Journal article, 2019-07-02)
      The CRISPR–Cas system is a powerful genome editing tool that functions in a diverse array of organisms and cell types. The technology was initially developed to induce targeted mutations in DNA, but CRISPR–Cas has now been ...
    • Chromatin accessibility established by Pou5f3, Sox19b and Nanog primes genes for activity during zebrafish genome activation 

      Pálfy, Máté; Schulze, Gunnar; Valen, Eivind; Vastenhouw, Nadine L. (Journal article; Peer reviewed, 2020-01)
      In many organisms, early embryonic development is driven by maternally provided factors until the controlled onset of transcription during zygotic genome activation. The regulation of chromatin accessibility and its ...
    • Chromatin and epigenetic features of long-range gene regulation 

      Harmston, Nathan; Lenhard, Boris (Peer reviewed; Journal article, 2013-06-13)
      The precise regulation of gene transcription during metazoan development is controlled by a complex system of interactions between transcription factors, histone modifications and modifying enzymes and chromatin conformation. ...
    • Chromatographic Fingerprinting and Quality Control of Herbal Medicines: Comparison of two officinal Chinese pharmacopoeia species of Dendrobii based on High-Performance Liquid Chromatography and Chemometric analysis 

      da Costa Mendes, Débora Sara (Master thesis, 2013-08-29)
      The fingerprinting quantitative analysis combining similarity evaluation, Principal Component Analysis (PCA) and Partial Least Squares Discriminant Analysis (PLS-DA) is a valid method for classification of herbal medicine ...
    • Chromatographic Fingerprinting of Chinese Grape Berries 

      Marques de Sousa, Pedro Filipe (Master thesis, 2014-04-14)
      Chromatographic fingerprints from three varieties of grapes produced in China (Giant Rose, Red Globe and Summer Black), were obtained by gas chromatography coupled with mass spectrometry. These grapes were subjected to ...
    • Chromosome aberrations in pressureinduced triploid Atlantic salmon 

      Glover, Kevin; Harvey, Alison C.; Hansen, Tom Johnny; Fjelldal, Per Gunnar; Besnier, Francois; Bos, J.B.; Ayllon, Fernando; Taggart, John B.; Solberg, Monica Favnebøe (Journal article; Peer reviewed, 2020)
      Background Triploid organisms have three sets of chromosomes. In Atlantic salmon, hydrostatic pressure treatment of newly fertilized eggs has been extensively used to produce triploids which are functionally sterile due ...
    • A chromosome-level assembly of the Atlantic herring genome-detection of a supergene and other signals of selection 

      Pettersson, Mats E.; Rochus, Christina M.; Han, Fan; Chen, Junfeng; Hill, Jason; Wallerman, Ola; Fan, Guangyi; Hong, Xiaoning; Xu, Qiwu; Zhang, He; Liu, Shanshan; Liu, Xin; Haggerty, Leanne; Hunt, Toby; Martin, Fergal J.; Flicek, Paul; Bunikis, Ignas; Folkvord, Arild; Andersson, Leif (Peer reviewed; Journal article, 2019)
      The Atlantic herring is a model species for exploring the genetic basis for ecological adaptation, due to its huge population size and extremely low genetic differentiation at selectively neutral loci. However, such studies ...
    • Chronology of Early to Mid-Pleistocene sediments in the northern North Sea: New evidence from amino acid and strontium isotope analyses 

      Chauhan, Teena; Sejrup, Hans Petter; Hjelstuen, Berit Oline Blihovde; Kaufman, Darrell S.; Baig, Irfan; Reinardy, Benedict T.I. (Journal article; Peer reviewed, 2022)
      Sediments deposited during glacial-interglacial cycles through the Early to Mid-Pleistocene in the North Sea are chronologically poorly constrained. To contribute to the chronology of these units, amino acid racemization ...
    • The chronology of reindeer hunting on Norway's highest ice patches 

      Pilø, Lars Holger; Finstad, Espen; Bronk Ramsey, Christopher; Martinsen, Julian Robert Post; Solli, Brit; Nesje, Atle; Wangen, Vivian; Callanan, Martin; Barrett, James H. (Peer reviewed; Journal article, 2018-01-24)
      The melting of perennial ice patches globally is uncovering a fragile record of alpine activity, especially hunting and the use of mountain passes. When rescued by systematic fieldwork (glacial archaeology), this evidence ...
    • Circulation along the northern slope of the Greenland-Scotland Ridge 

      Semper, Stefanie (Doctoral thesis, 2020-12-11)
      The Greenland-Scotland Ridge separates the subpolar North Atlantic from the Nordic Seas and constrains the flow of the upper and lower branches of the northern extremity of the Atlantic Meridional Overturning Circulation ...
    • Circulation and exchange of water masses on the Faroe Shelf and the impact on the Shelf ecosystem 

      Larsen, Karin Margretha Húsgarð (Doctoral thesis, 2009-02-11)
      The findings in this work can be listed as follows: FSW: Based on CTD data, the FSW is found to be relatively vertically homogeneous through-out the year inside the 100 m depth contour. Temperature measurements at coastal ...
    • Circulation and Ocean Driven Glacial Melting in a Greenland Fjord 

      Anhaus, Philipp (Master thesis, 2017-11-20)
      The Nioghalvfjerdsbræ (79NG) is a floating ice tongue on Northeast Greenland draining a large part of the Greenland Ice Sheet. New hydrographic observations show that Atlantic Water (AW, T > 0 °C, S > 34.3 psu) recirculates ...
    • Circulation and transformation of Atlantic and Arctic water masses in climate models 

      Langehaug, Helene Reinertsen (Doctoral thesis, 2011-12-09)
      Ocean heat transport and associated heat loss to the atmosphere contributes significantly to the anomalously mild climate of northwestern Europe and its variability. In this thesis, the circulation and transformation of ...
    • Circulation and water masses beneath the northern Ronne Ice Shelf, Antarctica 

      Nicholls, Keith W.; Makinson, Keith; Østerhus, Svein (Journal article, 2004-12-14)
      We present oceanographic data from beneath the northern Ronne Ice Shelf. The data were collected during the austral summer of 2002–2003 from four sites located near the ice front in the Ronne Depression. They consist of ...
    • The circulation of the Norwegian Sea- An investigation from space and ocean 

      Raj, Roshin Pappukutty (Doctoral thesis, 2014-01-10)
      The Norwegian Sea circulation plays a key role in maintaining the mild climate of the northwestern Europe via the transport of warm Atlantic Water pole-ward. The first paper addresses the advective currents connecting the ...
    • Circum-Arctic distribution of chemical anti-herbivore compounds suggests biome-wide trade-off in defence strategies in Arctic shrubs 

      Lindén, Elin; te Beest, Mariska; Aubreu, Ilka; Moritz, Thomas; Sundqvist, Maja K.; Barrio, Isabel C.; Boike, Julia; Bryant, John P.; Bråthen, Kari Anne; Buchwal, Agata; Bueno, C. Guillermo; Currier, Alain; Egelkraut, Dagmar Dorothea; Forbes, Bruce C.; Hallinger, Martin; Heijmans, Monique; Hermanutz, Luise; Hik, David S.; Hofgaard, Annika; Holmgren, Milena; Huebner, Diane C.; Høye, Toke T.; Jónsdóttir, Ingibjörg S.; Kaarlejärvi, Elina; Kissler, Emilie; Kumpula, Timo; Limpens, Juul; Myers-Smith, Isla H.; Normand, Signe; Post, Eric; Rocha, Adrian V.; Schmidt, Niels Martin; Skarin, Anna; Soininen, Eeva M; Sokolov, Aleksandr; Sokolova, Natalia; Speed, James David Mervyn; Street, Lorna E.; Tananaev, Nikita; Tremblay, Jean-Pierre; Urbanowicz, Christine; Watts, David A.; Zimmermann, Heike H.; Olofsson, Johan (Journal article; Peer reviewed, 2022)
      Spatial variation in plant chemical defence towards herbivores can help us understand variation in herbivore top–down control of shrubs in the Arctic and possibly also shrub responses to global warming. Less defended, ...
    • Citizen Seismology in the Arctic 

      Jeddi, Zeinab; Voss, Peter H.; Sørensen, Mathilde B.; Danielsen, Finn; Dahl-Jensen, Trine; Larsen, Tine B.; Nielsen, G.; Hansen, A.; Jakobsen, P.; Frederiksen, P.O. (Journal article; Peer reviewed, 2020)
      Landslides, earthquakes and other natural disasters are expected to increase in the Arctic, yet our ability to make informed decisions about safety is tightly limited by lack of data. As part of the Integrated Arctic ...