Browsing Faculty of Mathematics and Natural Sciences by Title
Now showing items 3280-3299 of 9873
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Functional analysis of metagenomes and metatranscriptomes using SEED and KEGG
(Peer reviewed; Journal article, 2011-02-15)Background: Metagenomics is the study of microbial organisms using sequencing applied directly to environmental samples. Technological advances in next-generation sequencing methods are fueling a rapid increase in the ... -
Functional analysis of the nonvisual opsins melanopsin and vertebrate ancient opsin (VA opsin) in Atlantic salmon (Salmo salar)
(Master thesis, 2017-06-15)The role of nonvisual photoreceptors is yet to be elucidated regarding the link to biological function. This study aims to characterise the expression pattern of melanopsin and vertebrate ancient opsin during early ... -
Functional analysis of tilS homologues in Bacteria and Archaea
(Master thesis, 2005-09-09)Out of all of the microorganisms sequenced so far about one third of the genes have unknown function. Several studies have shown that information on evolutionary relationships between unknown genes can aid in the prediction ... -
Functional and molecular characterisation of a unique double homozygous variant causing ABCA4-related retinopathy
(Master thesis, 2023-06-02) -
Functional assessment of 3'UTR regulatory elements using the zebrafish (Danio rerio) model system - towards modulating protein levels in Atlantic salmon (Salmo salar) for more sustainable aquaculture
(Master thesis, 2021-11-22)Post-transcriptional regulation is a complex process that encompasses a myriad of different structures and mechanisms. There are several indications that regulatory elements in the 3'UTR play an important role in the ... -
Functional characterisation of polybasic motifs in the nucleolar PtdIns(3,4,5)P3- interacting proteins proliferation-associated protein 2G4 and poly(ADP-ribose) polymerase 1
(Doctoral thesis, 2023-06-13)Fosfoinositid 3-kinase (PI3K)-signalveien er viktig for flere cellulære prosesser, inklusiv celleoverlevelse, proliferasjon og proteinsyntese. Den er godt beskrevet i cytoplasmaet. I tillegg kan fosfatidylinositol ... -
Functional characterisation of three human nicotinamide mononucleotide adenylyltransferases
(Doctoral thesis, 2008-08-25)Nicotinamide adenine dinucleotide, NAD, is an essential redox factor in many, primarily catabolic, hydrogen transfer reactions. While the redox reactions are not accompanied by a net loss of the pyridine nucleotides, NAD+ ... -
Functional characterization of Atlantic salmon (Salmo salar L.) PepT2 transporters
(Journal article; Peer reviewed, 2022)The high-affinity/low-capacity system Slc15a2 (PepT2) is responsible for the reuptake of di/tripeptides from the renal proximal tubule, but it also operates in many other tissues and organs. Information regarding PepT2 in ... -
Functional characterization of Carboxyl Ester Lipase variants causing diabetes and exocrine dysfunction
(Master thesis, 2016-11-21)The digestive enzyme carboxyl ester lipase (CEL) is mainly expressed in the acinar cells of the pancreas. We have previously identified disease-causing mutations in a variable number of tandem repeats (VNTR) domain, localised ... -
Functional characterization of ErbB3-binding protein 1 (EBP1) tumor mutants
(Master thesis, 2021-06-15)Four C-terminal EBP1 mutants, Q367H, Q367K, K373E-Ins K372R-Del, discovered in various cancer tumors werer investigated by PipStrip assay, whre Q367K had increased binding. Thermal denaturation and immonostaing localization. -
Functional characterization of N-terminal acetyltransferase 10 (NAA10) variants potentially causing disease
(Master thesis, 2019-12-14)Approximately 80-90 % of all eukaryotic proteins are co- or post-translationally acetylated on their N-terminus by a group of enzymes called N-terminal acetyltransferases (NATs) (Arnesen et al., 2009). To date, eight NATs ... -
Functional characterization of rare variants of SCHAD, a protein involved in unregulated insulin secretion
(Master thesis, 2018-06-26)Congenital Hyperinsulinism of Infancy (CHI) is a group of rare inherited disorders characterized by persistent hypoglycaemia due to inappropriate elevated secretion of insulin from the pancreatic beta cells. CHI can be ... -
Functional dissection of a genetic locus for visceral fat mass (11q23.3)
(Master thesis, 2021-06-01) -
Functional Evolution of Clustered Aquaporin Genes Reveals Insights into the Oceanic Success of Teleost Eggs
(Journal article; Peer reviewed, 2023)Aquaporin-mediated oocyte hydration is considered important for the evolution of pelagic eggs and the radiative success of marine teleosts. However, the molecular regulatory mechanisms controlling this vital process are ... -
Functional inequalities on path space of sub-Riemannian manifolds and applications
(Journal article; Peer reviewed, 2021)We consider the path space of a manifold with a measure induced by a stochastic flow with an infinitesimal generator that is hypoelliptic, but not elliptic. These generators can be seen as sub-Laplacians of a sub-Riemannian ... -
Functional investigations of the Ecdysone Receptor and production of ecdysone in the salmon louse (Lepeophtheirus salmonis)
(Doctoral thesis, 2016-05-24)The salmon louse Lepeophtheirus salmonis is a marine ectoparasitic copepod naturally infecting salmonid fishes in the Northern hemisphere. At present, salmon louse infections are the most severe disease problem in the ... -
Functional modifications associated with gastrointestinal tract organogenesis during metamorphosis in Atlantic halibut (Hippoglossus hippoglossus)
(Peer reviewed; Journal article, 2014-02-19)Background: Flatfish metamorphosis is a hormone regulated post-embryonic developmental event that transforms a symmetric larva into an asymmetric juvenile. In altricial-gastric teleost fish, differentiation of the stomach ... -
Functional Sites in Proteins: analysis and annotation of five nuclear functional sites for the ELM resource
(Master thesis, 2004)Proteins are molecular tools which a cell expresses from specific genes, where the protein has one or several functions. An example of a protein function can be to detect a particular hormone, transporting itself to the ...