Now showing items 1-3 of 3

    • Binding Leverage as a Molecular Basis for Allosteric Regulation 

      Mitternacht, Simon; Berezovsky, Igor N. (Public Library of Science, 2011-09-15)
      Allosteric regulation involves conformational transitions or fluctuations between a few closely related states, caused by the binding of effector molecules. We introduce a quantity called binding leverage that measures ...
      Peer reviewedJournal article
    • Coherent Conformational Degrees of Freedom as a Structural Basis for Allosteric Communication 

      Mitternacht, Simon; Berezovsky, Igor N. (Public Library of Science, 2011-12-08)
      Conformational changes in allosteric regulation can to a large extent be described as motion along one or a few coherent degrees of freedom. The states involved are inherent to the protein, in the sense that they are ...
      Peer reviewedJournal article
    • Comparing the intrinsic dynamics of multiple protein structures using elastic network models 

      Fuglebakk, Edvin; Tiwari, Sandhya Premnath; Reuter, Nathalie (Elsevier, 2015-05)
      Background: Elastic network models (ENMs) are based on the simple idea that a protein can be described as a set of particles connected by springs, which can then be used to describe its intrinsic flexibility using, for ...
      Journal article