• Combined RBE and OER optimization in proton therapy with FLUKA based on EF5-PET 

      Henjum, Helge; Dahle, Tordis Johnsen; Mairani, Andrea; Pilskog, Sara Margareta Cecilia; Stokkevåg, Camilla Hanquist; Boer, Camilla Grindeland; Redalen, Kathrine Røe; Minn, Heikki; Malinen, Eirik; Ytre-Hauge, Kristian Smeland (Journal article; Peer reviewed, 2023)
      Introduction Tumor hypoxia is associated with poor treatment outcome. Hypoxic regions are more radioresistant than well-oxygenated regions, as quantified by the oxygen enhancement ratio (OER). In optimization of proton ...
    • The FLUKA Monte Carlo code coupled with an OER model for biologically weighted dose calculations in proton therapy of hypoxic tumors 

      Dahle, Tordis Johnsen; Rusten, Espen; Stokkevåg, Camilla Hanquist; Silvoniemi, Antti; Mairani, Andrea; Fjæra, Lars Fredrik; Rørvik, Eivind; Henjum, Helge; Wright, Pauliina; Boer, Camilla Grindeland; Forsback, Sarita; Minn, Heikki; Malinen, Eirik; Ytre-Hauge, Kristian (Journal article; Peer reviewed, 2020)
      Introduction The increased radioresistance of hypoxic cells compared to well-oxygenated cells is quantified by the oxygen enhancement ratio (OER). In this study we created a FLUKA Monte Carlo based tool for inclusion of ...
    • Substantial Sparing of Organs at Risk with Modern Proton Therapy in Lung Cancer, but Altered Breathing Patterns Can Jeopardize Target Coverage 

      Boer, Camilla Grindeland; Fjellanger, Kristine; Sandvik, Inger Marie; Ugland, Maren; Engeseth, Grete May; Hysing, Liv Bolstad (Journal article; Peer reviewed, 2022-03-08)
      Enhancing treatment of locally advanced non-small cell lung cancer (LA-NSCLC) by using pencil beam scanning proton therapy (PBS-PT) is attractive, but little knowledge exists on the effects of uncertainties occurring between ...