• Cystatin C is glucocorticoid responsive, directs recruitment of Trem2+ macrophages, and predicts failure of cancer immunotherapy 

      Kleeman, Sam O.; Thakir, Tuba Mansoor; Demestichas, Breanna; Mourikis, Nicholas; Loiero, Dominik; Ferrer, Miriam; Bankier, Sean; Riazat-Kesh, Yosef J.R.A.; Lee, Hassal; Chantzichristos, Dimitrios; Regan, Claire; Preall, Jonathan; Sinha, Sarthak; Rosin, Nicole; Yipp, Bryan; de Almeida, Luiz G.N.; Biernaskie, Jeff; Dufour, Antoine; Tober-Lau, Pinkus; Ruusalepp, Arno; Bjorkegren, Johan L.M.; Ralser, Markus; Kurth, Florian; Demichev, Vadim; Heywood, Todd; Gao, Qing; Johannsson, Gudmundur; Koelzer, Viktor H.; Walker, Brian R.; Meyer, Hannah V.; Janowitz, Tobias (Journal article; Peer reviewed, 2023)
      Cystatin C (CyC), a secreted cysteine protease inhibitor, has unclear biological functions. Many patients exhibit elevated plasma CyC levels, particularly during glucocorticoid (GC) treatment. This study links GCs with ...