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Binding Leverage as a Molecular Basis for Allosteric Regulation
(Public Library of Science, 2011-09-15)
Allosteric regulation involves conformational transitions or fluctuations between a few closely related states, caused by the binding of effector molecules. We introduce a quantity called binding leverage that measures ...
Coherent Conformational Degrees of Freedom as a Structural Basis for Allosteric Communication
(Public Library of Science, 2011-12-08)
Conformational changes in allosteric regulation can to a large extent be described as motion along one or a few coherent degrees of freedom. The states involved are inherent to the protein, in the sense that they are ...