Department of Molecular Biology
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Recent Submissions
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Neuronal cell lipidomics and role of cholesterol in α-synuclein binding and aggregation
(The University of Bergen, 2019-03-22)α-Synuclein is an intrinsically disordered protein whose fold and multimeric state is strongly affected by its environment. The monomers of α-synuclein are enriched in the presynaptic terminals of dopaminergic ...Doctoral thesis -
Evidence that Listeria innocua modulates its membrane’s stored curvature elastic stress, but not fluidity, through the cell cycle
(Springer Nature, 2017-08-14)This paper reports that the abundances of endogenous cardiolipin and phosphatidylethanolamine halve during elongation of the Gram-positive bacterium Listeria innocua. The lyotropic phase behaviour of model lipid systems ...Journal article -
Characterization of regulatory T cells in Autoimmune Polyendocrine Syndrome type I, a model disease for autoimmunity
(The University of Bergen, 2018-12-21)The T and B lymphocytes of the adaptive immune system face the challenge of correctly recognizing antigens originating from a vast number of rapidly evolving pathogens, while ignoring those pertaining to the host itself. ...Master thesis -
Identification of Epigenetic Modifications Following Treatment with Olanzapine
(The University of Bergen, 2018-12-19)No chronic disease burdens the world more than psychiatric disorders (Collins et al., 2011), with an estimated 40% of the population in 30 European countries affected in any given year (Insel et al., 2012). Current medical ...Master thesis -
Characterization of NAA10 mutations in patients exhibiting phenotypes associated with N-terminal acetylation deficiency
(The University of Bergen, 2018-12-19)Approximately 80% of the proteins found in human cells are acetylated on their N-terminus, either partially or completely, by a group of enzymes called N-terminal acetyltransferases (NATs)^1. To date, seven NATs, ...Master thesis -
Direct photon measurements in pp and Pb-Pb collisions with the ALICE experiment
(Elsevier, 2017-11)Direct photon production in heavy-ion collisions provides a valuable set of observables to study the hot QCD medium. The direct photons are produced at different stages of the collision and escape the medium unaffected. ...Journal article -
Role of the class I PI3K p110ß and PtdIns(3,4,5)P3 in rRNA transcription in the nucleolus
(The University of Bergen, 2018-06-26)The phosphoinositide 3-kinase (PI3K) signalling pathway is one of the most altered pathways in human cancer. It is a complex pathway, when considering that ubiquitously expressed isoforms regulate different routes with ...Master thesis -
Functional characterization of rare variants of SCHAD, a protein involved in unregulated insulin secretion
(The University of Bergen, 2018-06-26)Congenital Hyperinsulinism of Infancy (CHI) is a group of rare inherited disorders characterized by persistent hypoglycaemia due to inappropriate elevated secretion of insulin from the pancreatic beta cells. CHI can be ...Master thesis -
Characterization of insertion variants of the carboxyl-ester lipase (CEL) gene - A role in pancreatic disease?
(The University of Bergen, 2018-06-26)Carboxyl ester lipase (CEL) is a digestive enzyme that is mainly expressed in the acinar cells of the pancreas. The CEL gene is highly polymorphic due to a variable number of tandem repeat (VNTR) region in the last exon. ...Master thesis -
Ca^2+-signalling in C. intestinalis notochord cells during embryonic development
(The University of Bergen, 2018-05-10)C. intestinalis notochord is an essential structure during embryonic development, conveying position and fate information, in addition to serving as a structural support and enabling locomotion during larval stage. ...Master thesis -
Endometrial cancer cells exhibit high expression of p110β and its selective inhibition induces variable responses on PI3K signaling, cell survival and proliferation
(Impact Journals, 2017-12-16)PTEN loss and constitutive activation of the class I phosphoinositide 3-kinase (PI3K) pathway are key drivers of endometrial tumorigenesis. In some cancer types, PTEN-deficient tumors are reliant on class I PI3K p110β ...Journal article -
BRCA1 promoter methylation: the influence on gene expression and the effect of long term drug treatment
(The University of Bergen, 2017-07-04)Breast cancer is the most common type of cancer among woman all over the world, with over 1.67 million new cases in 2012. Heritable breast cancer is closely linked to mutations in the tumor suppressor gene BRCA1, with ...Master thesis -
Depletion of the human N-terminal acetyltransferase hNaa30 disrupts Golgi integrity and ARFRP1 localization
(Portland Press, 2017-04-28)The organization of the Golgi apparatus (GA) is tightly regulated. Golgi stack scattering is observed in cellular processes such as apoptosis and mitosis, and has also been associated with disruption of cellular lipid ...Journal article -
Quantitative proteomics analysis of zebrafish exposed to sub-lethal dosages of β-methyl-amino-L-alanine (BMAA)
(Nature Publishing Group, 2016-07-12)The non-protein amino acid β-methylamino-L-alanine (BMAA) is a neurotoxin present in microalgae and shown to accumulate in the food web. BMAA has been linked to the complex neurodegenerative disorder of Guam and to increased ...Journal article -
First Things First: Vital Protein Marks by N-Terminal Acetyltransferases
(Elsevier, 2016-09)N-terminal (Nt) acetylation is known to be a highly abundant co-translational protein modification, but the recent discovery of Golgi- and chloroplast-resident N-terminal acetyltransferases (NATs) revealed that it can also ...Journal article -
Brd4 as a candidate protein for the recognition of histone H3 lysine 27 acetylation
(The University of Bergen, 2015-06-29)Post-translational modifications (PTMs) of histone tails are associated with the regulation of transcriptional processes. Patterns of histone modifications mark regions of high or low transcriptional activity, and are ...Master thesis -
Role of EPAC in cAMP-mediated actions in adrenocortical cells
(Frontiers, 2016-06-13)Adrenocorticotropic hormone regulates adrenal steroidogenesis mainly via the intracellular signaling molecule cAMP. The effects of cAMP are principally relayed by activating protein kinase A (PKA) and the more recently ...Journal article -
Similarity in Shape Dictates Signature Intrinsic Dynamics Despite No Functional Conservation in TIM Barrel Enzymes
(PLoS, 2016-03-25)The conservation of the intrinsic dynamics of proteins emerges as we attempt to understand the relationship between sequence, structure and functional conservation. We characterise the conservation of such dynamics in a ...Journal article -
Contribution of homeobox genes to the development of the oikoplastic epithelium, a major novelty of tunicate Larvaceans
(The University of Bergen, 2016-11-23)The development of complex organisms is controlled by numerous genes, including developmentally regulated transcription factors (TF) encoded by multiple gene families. A well diversified group of TFs is the superclass ...Doctoral thesis -
Functional characterization of Carboxyl Ester Lipase variants causing diabetes and exocrine dysfunction
(The University of Bergen, 2016-11-21)The digestive enzyme carboxyl ester lipase (CEL) is mainly expressed in the acinar cells of the pancreas. We have previously identified disease-causing mutations in a variable number of tandem repeats (VNTR) domain, ...Master thesis
