Department of Molecular Biology
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Recent Submissions
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BRCA1 promoter methylation: the influence on gene expression and the effect of long term drug treatment
(The University of Bergen, 2017-07-04)Breast cancer is the most common type of cancer among woman all over the world, with over 1.67 million new cases in 2012. Heritable breast cancer is closely linked to mutations in the tumor suppressor gene BRCA1, with ...Master thesis -
Depletion of the human N-terminal acetyltransferase hNaa30 disrupts Golgi integrity and ARFRP1 localization
(Portland Press, 2017-04-28)The organization of the Golgi apparatus (GA) is tightly regulated. Golgi stack scattering is observed in cellular processes such as apoptosis and mitosis, and has also been associated with disruption of cellular lipid ...Journal article -
Hemagglutinin-specific antibody responses following 2009 pandemic H1N1 influenza vaccination in healthcare workers
(The University of Bergen, 2016-06-01)Influenza, a respiratory virus, has lead to a substantial morbidity and mortality in humans. The most reliable way of preventing the infection is through vaccination. Due to the high rate of change in influenza surface ...Master thesis -
Quantitative proteomics analysis of zebrafish exposed to sub-lethal dosages of β-methyl-amino-L-alanine (BMAA)
(Nature Publishing Group, 2016-07-12)The non-protein amino acid β-methylamino-L-alanine (BMAA) is a neurotoxin present in microalgae and shown to accumulate in the food web. BMAA has been linked to the complex neurodegenerative disorder of Guam and to increased ...Journal article -
First Things First: Vital Protein Marks by N-Terminal Acetyltransferases
(Elsevier, 2016-09)N-terminal (Nt) acetylation is known to be a highly abundant co-translational protein modification, but the recent discovery of Golgi- and chloroplast-resident N-terminal acetyltransferases (NATs) revealed that it can also ...Journal article -
Brd4 as a candidate protein for the recognition of histone H3 lysine 27 acetylation
(The University of Bergen, 2015-06-29)Post-translational modifications (PTMs) of histone tails are associated with the regulation of transcriptional processes. Patterns of histone modifications mark regions of high or low transcriptional activity, and are ...Master thesis -
Role of EPAC in cAMP-mediated actions in adrenocortical cells
(Frontiers, 2016-06-13)Adrenocorticotropic hormone regulates adrenal steroidogenesis mainly via the intracellular signaling molecule cAMP. The effects of cAMP are principally relayed by activating protein kinase A (PKA) and the more recently ...Journal article -
Similarity in Shape Dictates Signature Intrinsic Dynamics Despite No Functional Conservation in TIM Barrel Enzymes
(PLoS, 2016-03-25)The conservation of the intrinsic dynamics of proteins emerges as we attempt to understand the relationship between sequence, structure and functional conservation. We characterise the conservation of such dynamics in a ...Journal article -
Contribution of homeobox genes to the development of the oikoplastic epithelium, a major novelty of tunicate Larvaceans
(The University of Bergen, 2016-11-23)The development of complex organisms is controlled by numerous genes, including developmentally regulated transcription factors (TF) encoded by multiple gene families. A well diversified group of TFs is the superclass ...Doctoral thesis -
Functional characterization of Carboxyl Ester Lipase variants causing diabetes and exocrine dysfunction
(The University of Bergen, 2016-11-21)The digestive enzyme carboxyl ester lipase (CEL) is mainly expressed in the acinar cells of the pancreas. We have previously identified disease-causing mutations in a variable number of tandem repeats (VNTR) domain, ...Master thesis -
A polybasic motif in ErbB3-binding protein 1 (EBP1) has key functions in nucleolar localization and polyphosphoinositide interaction
(Portland Press, 2016-07)Polyphosphoinositides (PPIns) are present in the nucleus where they participate in crucial nuclear processes, such as chromatin remodelling, transcription and mRNA processing. In a previous interactomics study, aimed to ...Journal article -
Transcriptomic profiling of Methylococcus capsulatus (Bath)during growth with two different methane monooxygenases
(Wiley, 2016-04)Methylococcus capsulatus (Bath) is a methanotroph that possesses both a membrane-embedded (pMMO) and a soluble methane monooxygenase (sMMO). The expression of these two MMO's is tightly controlled by the availability of ...Journal article -
Characterization of the dopamine receptor genes in salmon louse, Lepeophtheirus Salmonis
(The University of Bergen, 2016-06-01)Master thesis -
A Role for Weak Electrostatic Interactions in Peripheral Membrane Protein Binding
(Elsevier, 2016-03)Bacillus thuringiensis phosphatidylinositol-specific phospholipase C (BtPI-PLC) is a secreted virulence factor that binds specifically to phosphatidylcholine (PC) bilayers containing negatively charged phospholipids. ...Journal article -
On the chemistry, toxicology and genetics of the cyanobacterial toxins, microcystin, nodularin, saxitoxin and cylindrospermopsin
(MDPI, 2010-05-10)The cyanobacteria or “blue-green algae”, as they are commonly termed, comprise a diverse group of oxygenic photosynthetic bacteria that inhabit a wide range of aquatic and terrestrial environments, and display incredible ...Journal article -
Algal toxin azaspiracid-1 induces early neuronal differentiation and alters peripherin isoform stoichiometry
(MDPI, 2015-12-14)Azaspiracid-1 is an algal toxin that accumulates in edible mussels, and ingestion may result in human illness as manifested by vomiting and diarrhoea. When injected into mice, it causes neurotoxicological symptoms and ...Journal article -
The Schizosaccharomyces pombe JmjC-protein, Msc1, prevents H2A.Z localization in centromeric and subtelomeric chromatin domains
(PLOS, 2009-11-13)Eukaryotic genomes are repetitively packaged into chromatin by nucleosomes, however they are regulated by the differences between nucleosomes, which establish various chromatin states. Local chromatin cues direct the ...Journal article -
NAA10 mutation causing a novel intellectual disability syndrome with Long QT due to N-terminal acetyltransferase impairment
(Nature Publishing Group, 2015-11-02)We report two brothers from a non-consanguineous Irish family presenting with a novel syndrome characterised by intellectual disability, facial dysmorphism, scoliosis and long QT. Their mother has a milder phenotype including ...Journal article -
Fish zona radiata (eggshell) protein: A sensitive biomarker for environmental estrogens
(The National Institute of Environmental Health Sciences, 1997-04)Environmental estrogens have recently caused great concern because of their ability to mimic natural hormones and influence vital endocrine functions in humans and wildlife. The induction of vitellogenin (Vtg) synthesis ...Journal article -
A sensetive zonagenetic assay for rapid in vivo assessment of estrogenic potency of xenobiotics and mycotoxins
(The National Institute of Environmental Health Sciences, 1999-01)Mounting evidence confirms that hepatic biosynthetic processes are essential for female sexual maturation in fish, which is directly controlled by estrogens. These oogenetic events (zonagenesis and vitellogenesis) are ...Journal article
