Now showing items 1-20 of 64

    • Algal toxin azaspiracid-1 induces early neuronal differentiation and alters peripherin isoform stoichiometry 

      Hjørnevik, Linda Veka; Frøyset, Ann Kristin; Grønset, Toril Anne; Rungruangsak-Torrissen, Krisna; Fladmark, Kari Espolin (MDPI, 2015-12-14)
      Azaspiracid-1 is an algal toxin that accumulates in edible mussels, and ingestion may result in human illness as manifested by vomiting and diarrhoea. When injected into mice, it causes neurotoxicological symptoms and ...
      Journal article
    • Biochemical and cellular analysis of Ogden syndrome reveals downstream Nt-acetylation defects 

      Myklebust, Line Merethe; Van Damme, Petra; Støve, Svein Isungset; Dörfel, Max J; Abboud, Angèle; Kalvik, Thomas Vikestad; Grauffel, Cédric; Jonckheere, Veronique; Wu, Yiyang; Swensen, Jeffrey; Kaasa, Hanna; Liszczak, Glen; Marmorstein, Ronen; Reuter, Nathalie; Lyon, Gholson J; Gevaert, Kris; Arnesen, Thomas (Oxford University Press, 2014-12-03)
      The X-linked lethal Ogden syndrome was the first reported human genetic disorder associated with a mutation in an N-terminal acetyltransferase (NAT) gene. The affected males harbor an Ser37Pro (S37P) mutation in the gene ...
      Journal article
    • Biochemical and virological analysis of the 18-residue C-terminal tail of HIV-1 integrase 

      Dar, Mohd J.; Monel, Blandine; Krishnan, Lavanya; Shun, Ming-Chieh; Di Nunzio, Francesca; Helland, Dag Emil; Engelman, Alan (BioMed Central, 2009-10-19)
      Background The 18 residue tail abutting the SH3 fold that comprises the heart of the C-terminal domain is the only part of HIV-1 integrase yet to be visualized by structural biology. To ascertain the role of the tail region ...
      Journal article
    • The C-terminal domain of eukaryotic initiation factor 5 promotes start codon recognition by its dynamic interplay with eIF1 and eIF2 beta 

      Luna, Rafael E.; Arthanari, Haribabu; Hiraishi, Hiroyuki; Nanda, Jagpreed; Martin-Marcos, Pilar; Markus, Michelle A.; Akabayov, Barak; Milbradt, Alexander G.; Luna, Lunet E.; Seo, Hee-Chan; Hyberts, Sven G.; Fahmy, Amr; Reibarkh, Mikhail; Miles, David; Hagner, Patrick R.; O'Day, Elizabeth M.; Yi, Tingfang; Marintchev, Assen; Hinnebusch, Alan G.; Lorsch, John R.; Asano, Katsura; Wagner, Gerhard (Elsevier, 2012-06-28)
      Recognition of the proper start codon on mRNAs is essential for protein synthesis, which requires scanning and involves eukaryotic initiation factors (eIFs) eIF1, eIF1A, eIF2, and eIF5. The carboxyl terminal domain (CTD) ...
      Journal article
    • Carbohydrate metabolism during vertebrate appendage regeneration: What is its role? How is it regulated? A postulation that regenerating vertebrate appendages facilitate glycolytic and pentose phosphate pathways to fuel macromolecule biosynthesis 

      Love, Nick R.; Ziegler, Mathias; Chen, Yaoyao; Amaya, Enrique (Wiley, 2014-01)
      We recently examined gene expression during Xenopus tadpole tail appendage regeneration and found that carbohydrate regulatory genes were dramatically altered during the regeneration process. In this essay, we speculate ...
      Journal article
    • Characterisation of the paralytic shellfish toxin biosynthesis gene clusters in Anabaena circinalis AWQC131C and Aphanizomenon sp. NH-5 

      Mihali, Troco Kaan; Kellmann, Ralf; Neilan, Brett A. (BioMed Central, 2009-03-30)
      Background: Saxitoxin and its analogues collectively known as the paralytic shellfish toxins (PSTs) are neurotoxic alkaloids and are the cause of the syndrome named paralytic shellfish poisoning. PSTs are produced by a ...
      Journal article
    • Characterization of hARD2, a processed hARD1 gene duplicate, encoding a human protein N-α-acetyltransferase 

      Arnesen, Thomas; Betts, Matthew J.; Pendino, Frédéric; Liberles, David A.; Anderson, Dave; Caro, Jaime; Kong, Xianguo; Varhaug, Jan Erik; Lillehaug, Johan (BioMed Central, 2006-04-25)
      Background: Protein acetylation is increasingly recognized as an important mechanism regulating a variety of cellular functions. Several human protein acetyltransferases have been characterized, most of them catalyzing ...
      Journal article
    • CHEK2 Mutations Affecting Kinase Activity Together With Mutations in TP53 Indicate a Functional Pathway Associated with Resistance to Epirubicin in Primary Breast Cancer 

      Chrisanthar, Ranjan; Knappskog, Stian; Løkkevik, Erik; Anker, Gun Birgitta; Østenstad, Bjørn; Lundgren, Steinar; Berge, Elisabet Ognedal; Risberg, Terje; Mjaaland, Ingvil; Mæhle, Lovise; Engebretsen, Lars Fredrik; Lillehaug, Johan; Lønning, Per Eystein (Public Library of Science, 2008-08-26)
      Background: Chemoresistance is the main obstacle to cure in most malignant diseases. Anthracyclines are among the main drugs used for breast cancer therapy and in many other malignant conditions. Single parameter analysis ...
      Journal articlePeer reviewed
    • Cloning, expression and purification of Atlantic salmon (Salmo salar, L.) neuroglobin 

      Bjørlykke, Gry Aletta; Kvamme, Bjørn Olav; Slinde, Erik; Raae, Arnt Johan (Elsevier Inc., 2012)
      Neuroglobin (Ngb) exists only in small amounts in salmon brain. In order to study the protein in more detail salmon neuroglobin (sNgb) was cloned, hetereologously expressed in E.coli and purified. The protein had red ...
      Journal article
    • Comparing the intrinsic dynamics of multiple protein structures using elastic network models 

      Fuglebakk, Edvin; Tiwari, Sandhya Premnath; Reuter, Nathalie (Elsevier, 2015-05)
      Background: Elastic network models (ENMs) are based on the simple idea that a protein can be described as a set of particles connected by springs, which can then be used to describe its intrinsic flexibility using, for ...
      Journal article
    • Conservation and divergence of chemical defense system in the tunicate Oikopleura dioica revealed by genome wide response to two xenobiotics 

      Yadetie, Fekadu; Butcher, Stephen; Førde, Hilde E.; Campsteijn, Coen; Bouquet, Jean-Marie; Karlsen, Odd André; Denoeud, France; Metpally, Raghu; Thompson, Eric M.; Manak, J. Robert; Goksøyr, Anders; Chourrout, Daniel (BioMed Central Ltd., 2012-02-02)
      Background Animals have developed extensive mechanisms of response to xenobiotic chemical attacks. Although recent genome surveys have suggested a broad conservation of the chemical defensome across metazoans, global ...
      Peer reviewedJournal article
    • CorA is a copper repressible surface-associated copper(I)-binding protein produced in Methylomicrobium album BG8 

      Johnson, Kenneth; Ve, Thomas; Larsen, Øivind; Pedersen, Rolf B.; Lillehaug, Johan R.; Jensen, Harald B.; Helland, Ronny; Karlsen, Odd André (PLoS, 2014-02-03)
      CorA is a copper repressible protein previously identified in the methanotrophic bacterium Methylomicrobium album BG8. In this work, we demonstrate that CorA is located on the cell surface and binds one copper ion per ...
      Journal article
    • Depletion of the human N-terminal acetyltransferase hNaa30 disrupts Golgi integrity and ARFRP1 localization 

      Starheim, Kristian K.; Kalvik, Thomas Vikestad; Bjørkøy, Geir; Arnesen, Thomas (Portland Press, 2017-04-28)
      The organization of the Golgi apparatus (GA) is tightly regulated. Golgi stack scattering is observed in cellular processes such as apoptosis and mitosis, and has also been associated with disruption of cellular lipid ...
      Journal article
    • Dietary methylmercury alters the proteome in Atlantic salmon (Salmo salar) kidney 

      Nøstbakken, Ole Jakob; Martin, Samuel A. M.; Cash, Phillip; Torstensen, Bente Elisabeth; Amlund, Heidi; Olsvik, Pål A. (Elsevier, 2011-12-19)
      Background: Methylmercury (MeHg) is an environmental contaminant most known for its severe neurotoxic effects. Although accumulation of MeHg tends to be several folds higher in kidney compared to other tissues, studies ...
      Peer reviewedJournal article
    • Direct photon measurements in pp and Pb-Pb collisions with the ALICE experiment 

      Acharya, Shreyasi; Adam, Jaroslav; Adamová, Dagmar; Adolfsson, Jonatan; Aggarwal, Madan M.; Aglieri Rinella, G; Agnello, Michelangelo; Agrawal, Nikita; Ahammed, Zubayer; Ahmad, N; Ahn, SU; Alme, Johan; Altenkaemper, Lucas; Arsene, Ionut Christian; Bätzing, Paul Christoph; Djuvsland, Øystein; Dordic, Olja; Helstrup, Håvard; Hetland, Kristin Fanebust; Kileng, Bjarte; Langøy, Rune; Lardeux, Antoine Xavier; Lien, Jørgen André; Lindal, Svein; Lønne, Per-Ivar; Mahmood, Sohail Musa; Milosevic, Jovan; Nesbø, Simon Voigt; Nystrand, Joakim; Rehman, Attiq Ur; Richter, Matthias Rudolph; Røed, Ketil; Røhrich, Dieter; Skaali, Toralf Bernhard; Tambave, Ganesh Jagannath; Tveter, Trine Spedstad; Ullaland, Kjetil; Velure, Arild; Wagner, Boris; Wikne, Jon Christopher; Zhang, Hui; Zhao, Chengxin; Zhou, Zhuo; Zhu, Hongsheng; Qvigstad, Henrik; Aiola, Salvatore; Akindinov, Alexander; Alam, Sk Noor; Alba, José Luis Bazo; Aleksandrov, Dimitry; ALICE, Collaboration (Elsevier, 2017-11)
      Direct photon production in heavy-ion collisions provides a valuable set of observables to study the hot QCD medium. The direct photons are produced at different stages of the collision and escape the medium unaffected. ...
      Journal article
    • Discovery of Nuclear-Encoded Genes for the Neurotoxin Saxitoxin in Dinoflagellates 

      Stüken, Anke; Orr, Russell J. S.; Kellmann, Ralf; Murray, Shauna A.; Neilan, Brett A.; Jakobsen, Kjetill S. (Public Library of Science, 2011-05-18)
      Saxitoxin is a potent neurotoxin that occurs in aquatic environments worldwide. Ingestion of vector species can lead to paralytic shellfish poisoning, a severe human illness that may lead to paralysis and death. In ...
      Peer reviewedJournal article
    • Dissecting the Transcriptional Regulatory Properties of Human Chromosome 16 Highly Conserved Non-Coding Regions 

      Royo, José Luis; Hidalgo, Carmen; Roncero, Yolanda; Seda, María Angeles; Akalin, Altuna; Lenhard, Boris; Casares, Fernando; Gómez-Skarmeta, José Luis (Public Library of Science, 2011-09-13)
      Non-coding DNA conservation across species has been often used as a predictor for transcriptional enhancer activity. However, only a few systematic analyses of the function of these highly conserved non-coding regions ...
      Peer reviewedJournal article
    • Downregulation of N-terminal acetylation triggers ABA-mediated drought responses in Arabidopsis 

      Linster, Eric; Stephan, Iwona; Bienvenut, Willy V.; Maple-Grødem, Jodi; Myklebust, Line Merethe; Huber, Monika; Reichelt, Michael; Sticht, Carsten; Møller, Simon Geir; Meinnel, Thierry; Arnesen, Thomas; Giglione, Carmela; Hell, Rüdiger; Wirtz, Markus (Nature Publishing Group, 2015-07-17)
      N-terminal acetylation (NTA) catalysed by N-terminal acetyltransferases (Nats) is among the most common protein modifications in eukaryotes, but its significance is still enigmatic. Here we characterize the plant NatA ...
      Journal article
    • Efficacy of early diagnosis and treatment in women with a family history of breast cancer 

      Møller, Per; Reis, MM; Evans, G; Vasen, H; Haites, N; Anderson, E; Steel, CM; Apold, Jaran; Lallo, F; Mæhle, L; Preece, P; et al., - (Hindawi Publishing Corporation, 1999)
      BACKGROUND: Surveillance programmes for women at increased genetic risk of breast cancer are being established worldwide but little is known of their efficacy in early detection of cancers and hence reduction in ...
      Journal article
    • ELM: the status of the 2010 eukaryotic linear motif resource 

      Gould, Cathryn M.; Diella, Francesca; Via, Allegra; Puntervoll, Pål; Gemünd, Christine; Chabanis-Davidson, Sophie; Michael, Sushama; Sayadi, Ahmed; Bryne, Jan Christian; Chica, Claudia; Seiler, Markus; Davey, Norman E.; Haslam, Neill; Weatheritt, Robert J.; Budd, Aidan; Hughes, Timothy; Pas, Jakub; Rychlewski, Leszek; Trave, Gilles Michel; Aasland, Rein; Helmer-Citterich, Manuela; Linding, Rune; Gibson, Toby J. (Oxford University Press (OUP), 2009-11-17)
      Linear motifs are short segments of multidomain proteins that provide regulatory functions independently of protein tertiary structure. Much of intracellular signalling passes through protein modifications at linear motifs. ...
      Journal article